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February, 2018 Organ-on-a-Chip
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Models Heart Disease
Washington, D.C. — When studying diseases or testing potential drug therapies, researchers usually turn to cultured cells in Petri dishes or ex- periments with lab animals, but re- cently, researchers have been devel- oping a different approach: small, or- gan-on-a-chip devices that mimic the functions of human organs, serving as potentially cheaper and more ef- fective tools.
Researchers have built a new
device that is especially good for modeling atherosclerosis — the con- striction of blood vessels that is the leading cause of heart attacks and strokes. In a paper appearing in APL Bioengineering, from AIP Publishing, researchers illustrate how the new device can be used to study impor- tant inflammatory responses in cells that line the vessel in ways that could not be done in animal models. The research team also explains how this organ-on-a-chip could improve blood testing for patients. “Atherosclerosis is a very im- portant and complex disease,” says
Han Wei Hou, a biomedical engineer at Nanyang Technological University in Singapore. It develops when fat, cholesterol and other substances in the blood form plaque that accumu- lates on the inside walls of arteries. This buildup constricts the blood ves- sel, causing cardiovascular diseases. Understanding what regulates
this abnormal vessel constriction is crucial to studying and treating ves- sel disease and preventing acute car- diac arrest. While researchers have previously developed organ-on-a-chip models of blood vessels, those devices focused more on recreating the ves- sel’s biological complexity than on its shape and geometry — which are key factors in atherosclerosis, Hou says. “It involves not just the biological as- pect of endothelial dysfunction, but also the biomechanics of blood flow.” To address blood flow, the re-
searchers built a device that fits on a 1 in.2 (6.5 cm2) chip, consisting of two stacked chambers separated by a thin and flexible polymer membrane.
Continued on page 8 SEMI: Fab Spending Continued from page 1
levels of investment in 2018. This year, China is expected to
begin equipping many fabs con- structed in 2017. In the past, non- Chinese companies accounted for the most fab investment in China. For the first time, Chinese-owned device manufacturers will approach parity, spending nearly as much on fab equipment as their non-Chinese counterparts. In 2018, Chinese- owned companies are expected to in- vest about $5.8 billion, while non- Chinese will invest $6.7 billion. Many new companies, such as Yangtze Memory Technology, Fujian Jin Hua, Hua Li, and Hefei Chang
Xin Memory, are investing heavily in the region. Historic highs in equipment
spending in 2017 and 2018 reflect growing demand for advanced de- vices. This spending follows unprece- dented growth in construction spend- ing for new fabs also detailed in the SEMI World Fab Forecast report. Construction spending will reach all- time highs with China construction spending taking the lead at $6 billion in 2017 and $6.6 billion in 2018, es- tablishing another record. No region has ever spent more than $6 billion in a single year for construction. Web:
www.semi.org r
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Tech-Op-Ed ........................... 4 Tech Watch ........................... 10 Supply Chain ........................... 12 People.................................... 14 Business News......................... 16 Business Briefs........................ 17 Management......................... 18 EMS .................................... 20 ElectronicMfg. Prods............. 26 Production............................ 52 Partnering............................. 54 Distribution........................... 56 New Products....................... 100 High-Tech Events................... 112 Editorial Calendar................. 112 Advertisers Index................... 114
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Product Preview: ATX/MDM West..........................72
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