Measurement & Testing
CPACT researchers have published over 46 papers on process analytical techniques which are listed on their website (http://www.
cpact.com/research/publications/process_analytical_techniques)
Predictive Modelling and Process Performance Monitoring
This area of activity has been championed and progressed by Professor Julian Morris and Dr Alison Nordon and covers a wide range of activities including: - Multivariate statistical predictive modelling. Design of Experiments and Performance Monitoring. An EU Innovative Training Network “ModLife” at USTR is addressing two themes: Dynamic Multivariate Statistical Process Performance Monitoring and Data Fusion, and the Integration of Spectroscopic and Process Data
The scope of this area is illustrated by the fact that CPACT researchers have published over 120 papers in this area which are catalogued on their website
http://www.cpact.com/research/ publications
Conferences, Training and Continuous Professional Development:
CPACT provides an outstanding training environment for PhD students and postdoctoral researchers many of whom have gone on to gain careers and leading positions in industry and academia.
Members companies can also access a wide range of training opportunities for their employees including a series of popular training courses, webinars and six-monthly Research Days
CPACT initiated and run a conference series titled “Advances in Process Analytics and Control Technologies (APACT), www.apact.
co.uk, which is an open forum for the presentation and discussion of recent advances in engineering and scientifi c topics relevant to process analytics and control technologies. Plenary and keynote speakers describe the formulation and implementation of PAC strategies, review the benefi ts that can be achieved, and report recent developments. An instrument exhibition and full social programme are also included.
CPACT also established the triennial EUROPACT conference,
www.euro-pact.org, with the German Chemical Society and DECHEMA which was fi rst held in 2008 in Germany. Subsequent events were held in Glasgow in 2011, in Barcelona in May 2014 and in Berlin in May 2017.
CPACT Software toolboxes:
Over the years CPACT has developed a range of software toolboxes which are available at no extra cost to member companies and include: -
Data PreScreen: A Multivariate Statistical Data Pre-screening Toolbox has been designed and developed for use by the practising process engineer who wishes to pre-process and pre- screen process data prior to multivariate data analysis, process data modelling or building predictive and inferential models.
MultiDAT: is a Multivariate Statistical Modelling & Statistical Process Control Toolbox designed and developed for use by the practising process engineer who wishes to analyse process data for plant data interpretation, feature detection and process modelling. The toolbox builds on top of the MATLAB programming environment, with powerful user interface procedures providing user friendly, mouse/menu driven software.
BatchDAT: is a Multivariate Batch Process Statistical Process Control Toolbox which was initially designed and developed for GSK but can be used by practising process engineer who wish to analyse the scale up from fed batch seed to production vessels.
DoEMan: is a software tool for the Design of Experiments for Calibration Modelling to simplify the use of experimental designs for choosing suitable pre-treatment methods for calibration problems. The immediate benefi t of using experimental designs to select pre-treatment methods for calibration problems is that choosing the best pre-treatment method becomes a structured and objective activity.
Spectral Shooter: is a new CPACT MATLAB-based Toolbox that provides highly visual and easy-to-use state-of-art spectral data pre-processing methods, calibration transfer between different
45
Figure 2: CPACT Key skills and expertise in combining transferable research and technology for world class process control. Courtesy CPACT
instruments and calibration maintenance. It is aimed at allowing users to try novel algorithms that are not available in conventional chemometrics packages. As part of the functionality standard spectral data pre-processing has been added to allow comparison of the new tools with currently available methods.
All the CPACT toolboxes, except for DoEMan, are compiled and do not need MATLAB to run.
Feasibility Studies
Feasibility studies are small scale investigational studies within the general areas of process analysis, process performance monitoring and chemometrics which are designed to help specify research routes to more detailed projects. They are designed to be capable of being completed within 12 months and cost no more than £2 to £3K. Individual companies suggest the type of brief study that might be of benefi t to the them and a study programme is developed. Recent studies have included: -
- The analysis of Raman and UV-visible spectra of mixtures to assess process analytical options.
- The comparison of different spectroscopic techniques for target compounds in a process.
- The evaluation of handheld/portable Raman spectrometers for different samples.
- The application of CPACT software to process and spectroscopic data. Research/Innovation Institutes A*STAR, Singapore Hunan University, China
Imperial College London, UK IRTA, Spain
Newcastle University, UK Tel-Tek, Norway
University College London, UK University of Bergen, Norway University of Bremen, Germany University of Manchester, UK University of Strathclyde, UK University of York, UK
Centre for Process Analytics and Control Technology Partners Technology End Users
AstraZeneca Borealis BP
Bristol-Myers Squibb Domino
Fujifi lm Imaging Colorants GlaxoSmithKline
Johnson Matthey Plc
Centre for Process Innovation Merck Sharp & Dohme
Unilever R&D Vlaardingen B.V. The National Nuclear Laboratory
DSM Resolve Pfi zer
Syngenta Sanofi
Thomas Swan Table 1: CPACT current members by category
Author Details Tom Lynch CSci, CChem FRSC, Independent Analytical Consultant, Cricket House, High St, Compton, Newbury, RG20 6NY • Email:
tomlynch.lynch@
btinternet.com
Technology Vendors
Art photonics GmbH CAMO Software Clairet Scientifi c
Eigenvector Research Inc. Hellma
Indatech
KEIT Spectrometers Perceptive Engineering Polytec
Process Vision
Sartorius-Stedim Data Analytics tec5 AG
CPACT the Future?
As CPACT looks forward after 20 years it will strive to maintain its position as the leading process analytics and control technologies network in Europe and beyond by Infl uencing the production of next generation analysers and data analysis software to deliver advances in manufacturing processes to help members drive improvements and thus increased profi tability
It aspires to continue to extend training for both industrialists and academics and to produce high quality researchers and trained PAT scientists who can assist access to the latest research and enable technology transfer. CPACT can also help companies assess new technologies through short feasibility studies and then assist coordinate grant applications to leverage R&D funding from a range of sources.
CPACT are keen to explore further interactions with the petroleum and petrochemical industries and further information and contact details can be found on their website http://www.
cpact.com/
Acknowledgements
The author would like to acknowledge the assistance of Prof David Littlejohn, Prof Julian Morris and Natalie Kerr from CPACT in the preparation of this article.
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