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LABORATORY PRODUCTS


Partnership Delivering Optimum Solutions in Freeze Drying Technology


Linkam Scientific Instruments and freeze drying technology, Biopharma Technology Limited, celebrate ten years of partnership in supplying solutions to the pharmaceutical industry.


Biopharma Technology Limited (BTL) was founded in 1997 to develop freeze drying solutions to multiple materials in the world of pharmaceuticals. Freeze drying, also known as 'lyophilisation,' is a method of processing a liquid product into a dry solid product. In 2001, Director of Research at BTL, Dr Kevin Ward, came across Linkam and their range of temperature controlled stages. Freeze drying had often been a conducted in a hit and miss process without clear knowledge of the critical temperatures needed to produce the best product. The ability to provide accurate thermal characterisation right down to -196°C took the guesswork out of the process quickly and simply. The two companies went on to develop a number of instruments, the latest being the Lyostat 3 freeze drying microscope. The combination of BTL's applications knowledge and Linkam's instrumentation expertise brings a real added-value product to the freeze drying market place.


A typical experiment will look at the temperature at which a product undergoes collapse as this is the single most important characteristic for almost all freeze drying formulations. The Lyostat3 system uses polarised light microscopy to capture images of the sample's structural changes as temperature increases, information that is vital for successful freeze drying. This data is invaluable when developing a freeze drying cycle from scratch or in helping to identify the small adaptations in a freeze drying cycle that can transform the process operating costs. The advantages of a tailored production process are obvious; research has shown that a 1°C increase in product temperature can result in as much as a 13% increase in primary drying rate, demonstrating that thermal accuracy can transform process operating efficiency and costs.


The collaboration has also brought benefits to BTL through being able to provide quality pictures to illustrate the process at varying precisely controlled temperatures and pressures. For Linkam, it has been the benefit of being at the leading edge of an exciting and growing market. Freeze drying is growing. Whereas it used to be solely the domain of big pharma companies, it is now the smaller, specialty businesses in the fields such as biotherapeutics and biopharmaceutics that are using the BTL technology to study bigger, more complex molecules.


Circle no. 392


Bottle Top Dispenser Ceramus®


is the bottle top dispenser with ceramic piston from Hirschmann Laborgeräte. The calibration is, by means of


the combination of a micro-step volume adjustment and the step gauge, valid for the device's lifetime; a recalibration is not necessary. All valves and tubes can be disassembled within a few seconds by the user and therefore provide the possibility to clean the device easily. The new reagent recirculation system makes priming, for example, when starting on a fresh bottle or after stopping the operation for quite a long time, simple and almost without loss of reagent, while been easy on the environment.


Circle no. 393


Cambridge Companies Collaborate in the Launch of New Products for Flow Chemistry


Uniqsis Ltd and Cambridge Reactor Design Ltd (CRD) are collaborating in the commercialisation of an advanced cooling system for continuous flow reactors used in flow chemistry. Known as the FlowSyn Polar BearTM


controlled mixing and cooling of reagents at temperatures down to -88°C. The high performance Polar BearTM


, the new system enables chiller


module was developed in conjunction with the Ley Group (Innovative Technology Centre), Cambridge, England, and is specifically intended for flow chemistry applications. Designed as a fully integrated plug-and-play module, the Polar BearTM


uses advanced cooling technology without the need for solid CO2, solvents or heat transfer fluids to deliver rapid cooling down to -88°C at the simple touch of a button.


When partnered with the Uniqsis FlowSyn continuous flow reactor, it becomes the perfect tool for rapid pre-cooling of reagents and controlled mixing and cooling of reagents in highly exothermic flow chemistry reactions. Solutions for cooling flow chemistry reactions below -70°C have historically been cumbersome and inconvenient, involving pressurised gas cylinders and/or heat exchangers. With its fully integrated plug-and-play design, the Polar BearTM


simple to operate, as well as providing superb cooling performance. Paul Pergande, Group MD of Uniqsis commented: “We are very pleased to be able to collaborate with CRD on the commercialisation of this important new product.


Circle no. 394


With their expertise in product development for the chemical industry, CRD are in an excellent position to partner us in our mission to broaden the capability and applications of FlowSyn. We are already working with them on commercialising a second product which will be released in the coming weeks - a new gas module which will deliver a gas-saturated solvent input to the FlowSyn flow reactor.” The Polar BearTM


module is


compatible with all FlowSyn coil reactors and mixer blocks and works in combination with and can be controlled by any FlowSyn system.


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For example, when combined with FlowSyn Auto-LF, series of combinatorial experiments, each at a different sub ambient temperature, can automatically be performed in sequence. The Polar Bear is available as a standalone chiller unit with its own control unit or integrated with FlowSyn to make up the FlowSyn Polar BearTM


system.


Both options are available from Uniqsis who will be selling and supporting the FlowSyn Polar BearTM


through its


offices in the UK and USA and through its international distribution network.


Circle no. 395


is both easy to install and


LAB ASIA - MAY/JUNE 2011 - LABORATORY PRODUCTS


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