88 Index of Advertisers


Achema 2018 Analytica 2018 Arablab 2018


81 61 70


Axetris 14 Borosil Glass Works Ltd BVA Auctions


Cargille Laboratories Carver, Inc


67 41 87 48


CRYSTE 79 Ellutia 15 Eprep 75 Erlab Group ErreDue SpA ES Industries


Fisher Scientifi c FR


63 17 16 51


GFL Gesellschaft für Labortechnik mbH Gilson SAS


Hanna Instruments® Hiden Analytical Ltd Integra


Julabo GmbH


Lab Indonesia 2018 LCTech GmbH


Lightpath Optical (UK) Ltd LMS Ltd


LNI Swissgas


Making Pharmaceuticals Europe Merck Millipore SA Metrohm AG


Mitsubishi Chemical Analytech Co Ltd Japan USA


87 55


OBC,42 25,87 57


65,87 73 12 87 71 13 53


OFC,35 23 39


NuAire, Inc


Pfeiffer Vacuum GmbH Pittcon 2018 PolyScience Priorclave Ltd PS Analytical


Restek Corporation


Shimadzu Europa GmbH Specac Ltd


Starna Scientifi c Ltd


Tosoh Bioscience GmbH Velp Scientifi ca Srl Vici AG International


31 59 50 49 43 26 19


IFC 27 47 18 47 11


Wiggens 69


Profi ling Microsensors Provide Exact Localised Point Measurements


The combination of Presens Precision Sensing’s new and easy to handle Profi ling Microsensors (PM) for oxygen or pH with either the automated or manual Micromanipulator and one of its well proofed meters allow safe insertion into samples and precise vertical localisation for point measurements. They also perform stable and vibration-free measurements for extended periods of time. In addition, repeated profi ling is possible. Customers measuring in semi-solid substrates, such as sediments, microbial mats or biofi lms will profi t from the new PreSens products.


The PMs are the sturdiest microsensor version PreSens offers, with a fi rmer fi bre construction and a splash proof metal housing. They have a close fi tting fi bre guidance and the sensor tip itself is protected by a blunt steel cannula and can be extended with a turning mechanism. The measuring range for oxygen is either 0 - 100% O2, or 0 - 10% O2 and covers a pH range of 5.5 - 8.5. Due to the optical measurement method there is no electrical interference to worry about. The different types of oxygen and pH microsensors allows measurements in smallest sample volumes or inside tissues.


44090pr@reply-direct.com


New Brochure Features a Wide Range of Autoclaves and Media Preparators


Systec GmbH’s new product brochure is available now. The brochure has been redesigned and provides an overview of the wide product range of autoclaves and media preparators available. Customers can choose from over 70 different autoclaves, with chamber volumes ranging from 23 to 1580 litres, universal installation options as fl oor standing and bench-top units and numerous additional options.


The brochure also includes an overview of the Systec Mediafi ll dispensing and dosing system as well as the Systec Mediaprep media preparators (nutrient medium preparators and nutrient medium sterilisers), which have been optimised for the preparation, sterilisation and sterile fi lling of liquids, such as agar culture media, peptone water and buffer solutions or other sterile liquid media. These are available in seven sizes with capacities ranging from 10 to 120 litres of media.


Customers can rely on Systec’s 20 plus years of expertise in the fi elds of steam sterilisation and process development, even of the most complex autoclave processes. Download the new brochure at http://www.systec-lab.com/new-product-brochure/. For further information on Systec products visit www.systec-lab.com.


44204pr@reply-direct.com


Highly Effi cient Synthetic mRNAs


Amsbio announces the launch of a new service for synthesis of custom-designed, highly modifi ed mRNAs prepared by an advantageous in vitro transcription methodology.


Traditional approaches for engineering changes in cellular expression profi les have employed mostly DNA or RNA based viral and non-viral vectors. Unfortunately, these methods carry high risks, due to genomic integration with permanent genetic alteration of cells, and safety and ethical concerns relating to the use of DNA-based vectors in human clinical therapy. Using in vitro synthesised mRNAs offers an advantage if these crucial permanent changes are not needed and the associated problems can be avoided if transient gene expression changes are suffi cient or even an advantage.


Until recently concerns about RNA degradation problems have halted widespread use. Recent advances in the availability of synthetic mRNAs (syn-mRNAs) prepared using in vitro transcription methodologies has increased confi dence in working with syn-mRNAs.


The Amsbio custom synthetic mRNA service uses -containing mRNA which is translated more effi ciently than its unmodifi ed counterpart, which results in higher protein expression and also reduces the innate antiviral response. The new Amsbio service includes: synthesis of synthetic DNA, plasmid cloning, purifi cation, full DNA sequencing documentation, PCR amplifi cation of insert, purifi cation and subsequent RNA synthesis by in vitro transcription, purifi cation and characterisation. Amsbio synthetic mRNA is made to research grade for development applications and to GMP grade for cell therapy.


Dr Dusko Ilic, Reader in Stem Cell Science at Kings College London Faculty of Life Sciences & Medicine commented: “ I am pleased to see Amsbio are launching an IVT mRNA service.” He added: “An ideal reprogramming of somatic cells into induced pluripotent stem cells (iPSC) would utilise genome non-integrating vector systems. Among several available on the market today, I believe that modifi ed synthetic mRNA, as offered by Amsbio, is the best. It is safe, easy to work with and the reprogramming effi ciency is reasonably high. Although the reprogramming protocol with mRNA may seem more laborious than others, it is quite the opposite. The iPSC lines can be used right away - reprogramming and pluripotency marker characterisation of single clones can be done in a month, whereas other genome non- integrating vector systems require extensive passaging before the vectors become undetectable and we could start with characterisation.”


44722pr@reply-direct.com


INTERNATIONAL LABMATE - JANUARY/FEBRUARY 2018


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