Chromatography 13
New Protein A Chromatography Resin Increases Monoclonal Antibody Purification by up to 40%
GE Healthcare introduces a new Protein A chromatography resin, MabSelect PrismA, which will help biopharmaceutical manufacturers improve their monoclonal antibody (mAb) purification capacity by up to 40%. The resin is also significantly more alkaline- stable, meaning that MabSelect PrismA can be cleaned with a higher concentration of sodium hydroxide to better control cross- contamination and bioburden risks.
MabSelect PrismA addresses a number of key challenges, including the increased upstream titers. The new resin is highly efficient due to its excellent binding capacity, which is critical, because it determines how much resin is needed to purify a certain amount of protein.
“Biopharma companies are constantly looking for more ways to increase their output, and Protein A has a critical role to support these efforts. The thorough research and development work that we have carried out to create MabSelect PrismA sets a new standard for mAb purification. To put it simply, with this chromatography resin our customers will be able to produce more biopharmaceuticals out of their existing manufacturing equipment. Protein purification is no longer a bottleneck, but driving higher productivity and shorter manufacturing lead times for our customers,” said Jan Makela, General Manager, BioProcess, GE Healthcare Life Sciences.
MabSelect PrismA has been developed at the GE Healthcare Life Sciences site in Uppsala, Sweden, where the resin is also manufactured. The factory in Uppsala is one of the largest manufacturing facilities for chromatography resins in the world, and between 2017 and 2022 GE is annually investing up to USD 70 million in the production facility to significantly increase its capacity.
44304pr@reply-direct.com Smart Gas Generators
LNI Swissgas, based in Geneva, Switzerland, is a leading organisation in gas calibrators, blenders, generators and linearisation systems.
The company develops, manufacture and sell products for Air Pollution Monitoring, Emission & Process, Automotive and Laboratories.
The product portfolio includes: High precision calibrators for gas applications, Hydrogen, zero air, and nitrogen 19” rack generators for APM and CEM, Hydrogen, zero air, and nitrogen generators for GC and LCMS applications, Ozone Generators for low concentrations and Permeation tubes.
All products are equipped with internal diagnostic systems and designed for biodirectional remote control.
LNI Swissgas maintains ISO 9001 for corporate activities, research and manufacturing. In order to satisfy high metrological requirements, LNI Swissgas, has been working for several years with its own accredited ISO 17025 calibration laboratory.
Expanded Portfolio for Biomolecules Purification Announced
With the increased interest in the purification of a wider variety of biomolecules, the portfolio of Kromasil 300 Å has been expanded to support these applications.
The Kromasil 300 Å line of HPLC products is now shipping with C18, C8, C4 and diC4 derivatisations for scientists and engineers exploiting selectivity and loadability for purification of API and impurity isolation. In particular, the new Kromasil 300 Å diC4 has different characteristic than a classic C4, enabling new opportunities to remove impurities from peptide and protein crudes.
For more information, visit
www.kromasil.com 44181pr@reply-direct.com
New Peptide Phenyl-Hexyl and AQ-C18 HALO Fused-Core Columns
Advanced Materials Technology have launched two new advanced LC phases for your LC separation toolbox – HALO Peptide Phenyl-Hexyl and HALO AQ-C18.
HALO 160 Å Peptide Phenyl-Hexyl – a BioClass Fused-Core HPLC/UHPLC column – is specifically designed to offer alternative selectivity to C18 and CN columns, for separations of peptides and tryptic digests. It offers excellent separation of peptide and protein digests, unique selectivity, rugged stability and excellent lot-to-lot reproducibility.
HALO 90 Å AQ-C18 is a brand new bonded phase designed to complement the classic HALO C18 and extend its usefulness to 100% aqueous mobile phases. Advantages include resistance to dewetting, compatibility with 100% aqueous mobile phases, alternative selectivity to HALO C18 and longer retention of polar compounds than classic C18 phases under most mobile phase conditions.
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