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chromatography • spectroscopy 31

Dissolution and particle size via Raman imaging

Malvern’s Morphologi G3-ID enables the efficient direction of spectroscopy to particle populations of interest, classified on the basis of particle size and shape. This makes it a valuable tool for the analysis and development of complex, multicomponent inhalation drug dispersions. Morphologi G3-ID can help

provide evidence of bioequivalence and can advance the drug validation process through supporting the use of biowavers. Biowavers apply in regulatory drug

approval processes where the efficacy and safety sections of the validation process can be approved based on in vitro equivalence testing. Case study evidence relatse the

in vitro dissolution behaviour of drug product to component-specific particle size data gathered using the Morphologi G3-ID. By combining particle imaging with

Parallel synthesis develops better catalysts

The SDG Group within the Department of Chemistry at Imperial College, London, UK, has selected the Asynt DrySyn MULTI and parallel synthesis kits to provide them with a safer, more convenient and productive way of synthesising novel organometallic compounds in their search for new better performing catalysts. As part of the Catalysis, Sustainability and Applied

Inorganics Group within the Department of Chemistry the SDG Group’s main research interest resides in the development of well-defined metal-based species and their use in organic reactions of broad interest. Working in conjunction with industrial partners

including BP, Johnson Matthey and Bayer Cropscience the SDG Group has used its considerable expertise and experience to develop novel families of complexes, active in catalysis, and unveil their activation/reactivity modes The Group’s ultimate goal is to identify better

performing catalysts, more sustainable synthetic approaches and deeper understanding of thereaction pathways. Affordably priced the DrySyn MULTI converts

any standard hotplate stirrer into a reaction block accommodating three flasks or up to 12 reactions in tubes or vials. Made of chemically resistant, anodised aluminium, DrySyn MULTI heating blocks offer excellent heating performance to over 300ºC and can heat a reaction flask 25 per cent faster than an oil bath.

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Raman spectroscopy, the Morphologi G3-ID enables size, shape and chemical identification in a single instrument. Able to measure particles across the size range 0.5 microns to several

Cost-effective protein profiling

Two-dimensional electrophoresis (2DE) is the most cost-effective protein profiling technology and is the only technology in which the constituents of a protein sample can be entirely visualised in a single gel. However, current technical limitations will need to be effectively tackled for these advantages to be leveraged and market growth to be maximised. New analysis from Frost & Sullivan, European

2-Dimensional Electrophoresis Market finds that the market earned revenues of about $130.0 million in 2008 and estimates this to reach nearly $159.2 million in 2015. The following segments are covered in the research: two-dimensional gel electrophoresis, liquid chromatography and mass spectrometry. “The global recession is bound to affect

government research spending which is like oxygen to academic researchers,” remarks Frost & Sullivan Research Analyst Rasika Ramachandran. “The current economic situation is therefore a blessing in disguise for the 2DE industry as researchers will be on the prowl for cheaper technologies in a cash- crunched climate. Participants in the market should capitalise on the prevailing situation to improve their revenues.” The European 2DE market is projected to

grow at a better rate in the near term, as academic researchers – the main consumers of these products – are likely to invest more in cheaper alternatives for protein expression studies, such as 2DE. Sample preparation solutions are never ‘one-

size-fits-all’ and can vary dramatically from one kind of sample to the other. They can also differ depending on which part of the proteome the researcher wants to study. Companies therefore find it very difficult to

come out with sample preparation kits that will effectively address the varied needs of the market. A large number of products are required to address this market, but each of these products will enjoy only a limited response due to the differing needs of customers. “Sample preparation is a major challenge

that the industry needs to overcome,” states Ramachandran. “It affects both the reproducibility and the resolution of the 2DE experiment which, in turn, influences the end results.” It is advisable for market participants to focus

on determining the kinds of samples that are the most widely studied in the market. Following this, a feasibility analysis to check the financial viability of developing a sample preparation kit for such samples should be conducted. This can help market participants to more effectively fulfil varied sample requirements. However, the industry has to consider that

customers need to be provided strong technical support. This aspect, therefore, also has to be factored into any feasibility study related to the development of sample preparation kits.

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millimeters, the instrument captures images of individual particle species using powerful optical technology. The resulting data enable the

classification of particles on the basis of size and shape, ahead of analysis with Raman spectroscopy, which delivers chemical characterisation. These capabilities make Morphologi

G3-ID a powerful tool for the development of suspension nasal sprays and dry powder inhaler formulations, where it enables targeted quantitative, physical and chemical characterization of the active pharmaceutical ingredient within a blend.

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