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22 chromatography • spectroscopy

“This combination of state-of-the-art technology and low-dispersion flow path is engineered to provide the high-peak capacity and sensitivity needed to analyse complex biomolecules.”

with simultaneous charge, size and polarity HPLC separations.

Te company has also added five phases to its family of Termo Scientific Accucore solid core HPLC columns: Accucore Polar Premium, a rugged amide-embedded C18 phase offering complementary selectivity to conventional C18 columns; Accucore Phenyl-X, featuring a proprietary reversed- phase shape selectivity with high aromatic selectivity; Accucore C30, designed for high shape selectivity for hydrophobic, long chain, structurally related isomers; Accucore Urea-HILIC for HILIC, designed for selectivity and low ion exchange activity; and Accucore 150-Amide-HILIC, designed to separate hydrophilic biomolecules in HILIC mode, intended for glycan separations.

Also new to the portfolio are Acclaim SEC-300 and SEC-1000 size exclusion HPLC columns designed for high-resolution separation

Chip-based mass spectrometry instrument

Microsaic Systems is the only producer of mass spectrometry instrumentation using Micro-Electrical-Mechanical Systems (MEMS) technology. Now advances in the new chip-based instrument, the Microsaic 4000 MiD, offers an enhanced unit with an even smaller footprint. Microsaic Systems is the first and

only company to have commercialised MS (mass spectrometry) technology on a chip based on MEMS technology originating at the highly regarded Optical and Semiconductor Devices Group at Imperial College London. The company’s breakthrough

product, the 3500 MiD launched in January 2011, represented a step change in the ease of use and footprint of mass spectrometry. The Microsaic 4000 MiD is the

culmination of over a decade of research, bringing together two high tech fields – chemical analysis and silicon micro-engineering – to make possible a

transformative capability in detection. Its low operating cost and small footprint make the instrument deployable in a wide range of applications where mass spectrometry has not been able to reach - until now. The next generation of the chip-

based technology made its US debut at Pittcon 2013 is now even smaller. As a result the Microsaic 4000 MiD fits even more comfortably into a standard lab fume hood, opening up further opportunities in the field of reaction monitoring. Users are able to increase the use

of mass spectrometry in the lab, while benefiting from significant cost savings, owing to fewer necessary structural components such as gas generators and air conditioning. There are also sizeable savings with the use of ‘Plug and Play’ components which enable users to maintain the system themselves, resulting in less downtime and greater flexibility within the laboratory.

“With the premier launch of the

Microsaic 4000 MiD and future plans for our growing portfolio of chip-based technology, the Microsaic exhibit at PITTCON will demonstrate how we work with and enable our customers to improve their laboratory operations,” said Colin Jump, CEO, Microsaic Systems. “Offering the smallest footprint in the market, the Microsaic 4000 MiD is a fully integrated, versatile, portable MS system designed for bench chemists. The core technologies are chip-scale versions of traditional mass spec components which can be interchanged rapidly by the user. This modular approach allows users to maintain the system without the need for expensive service contracts and time- consuming call-outs.” The company has successfully

miniaturised mass spectrometry by integrating the key MS components onto patented chip technologies called ionchip, spraychip and vac-chip. Microsaic’s MS products retain the speed

and sensitivity of larger, conventional MS systems but are substantially smaller, lighter, consume less energy and have lower running costs. The company’s first product, the

Microsaic 3500 MiD, was launched in January 2011 and is the world’s smallest MS system. MS is widely accepted as for

identifying individual chemicals in samples and is used routinely across multiple sectors, including government, energy, utilities, pharmaceutical, diagnostics and healthcare, environmental, food and drink, security and defence, and industrial chemicals. Microsaic Systems plc was

established in 2001 to develop miniaturised MS instruments based on MEMS originating at the Optical and Semiconductor Devices Group at Imperial College London.

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of water soluble polymers and oligomers. Tey are optimised for determining molecular weight distribution and characterisation of water soluble polymers used in a wide range of products found in pharmaceuticals.

BID for high sensitivity Shimadzu Corporation has launched the Tracera, a high-sensitivity GC. Tracera is equipped with the newly-developed barrier discharge ionisation detector (BID) which is capable of detecting all types of trace organic and inorganic compounds, with the exception of helium and neon, at the 0.1 ppm level. Tracera GC is applicable for many types of high-sensitivity analyses typically performed with GC systems incorporating multiple detectors.

Gas chromatographs are used for R&D and quality control in a number of fields, involving petrochemistry, fine chemicals, the environment, pharmaceuticals, foods, electronics/semiconductors,

and fragrances. In recent years, demands for higher sensitivity and trace quantity analyses have increased. Examples include impurity analysis on the order of a few ppm for materials used in fine chemical products, and gas purity analysis for semiconductor manufacture.

Termal conductivity detectors (TCD) and flame ionisation detectors (FID) are general-purpose detectors used in conventional gas chromatographs. A TCD detects a variety of inorganic and organic compounds, excluding the carrier gas component, but the sensitivity is insufficient. An FID is capable of detecting trace components at the ppm level, but can only detect organic compounds (excluding formaldehyde and formic acid). Analysis has thus required complex systems incorporating a variety of detectors to suit the target component.

With this issue in mind, Shimadzu

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