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ANALYTICAL AND LABORATORY EQUIPMENT 13


microcapsules at a lab and pilot scale.


Fig. 2. Schematic displaying the structural differences between a matrix and core- shell microcapsules.


developed a 3-Fluid nozzle system for their spray drying technology1, 5, 6, which allows encapsulation of a product within core-shell microcapsules (Fig. 2, displays the structural differences between a matrix and core-shell microcapsule) in a single step process.


For this 3-Fluid nozzle system three separate channels are available, one each for core liquid, shell (usually a polymer) liquid and atomising gas (Figure 1c).


Te system is set up in such a manner that both the shell and core liquids meet at the tip of the nozzle to form a concentric liquid, which is atomized and dried to form the core-shell microcapsules.


Use of this innovative system has already enabled scientists to successfully encapsulate fish oil (Fig. 3a.5


, a fluorescent marker (Fig.3b7 solution of diclofenac1 , within core-


shell microcapsules. Tis method not only enabled appropriate amounts of the solutions to be encapsulated, while potentially offering greater control over the release of the encapsulated material, but it also provided additional protection to the encapsulated material by enabling elimination of the emulsion preparation step.


Te recent work performed with the 3-Fluid nozzle has demonstrated how spray drying could be employed in the future as a standard methodology to produce core-shell


References: 1


Te incorporation of the 3-Fluid nozzle into the BÜCHI spray dryer does not reduce the reliable and simple nature of the entire (spray drying) operation, and only requires one additional feed pump to be added to the setup. It is anticipated that this system has the ability to significantly increase the number of products that can be microencapsulated by spray drying, and in the future may be employed at an industrial setting.


Indeed the lack of reliable,


efficient and simple production techniques has hindered the commercial application of core-shell microcapsule4


. Tis gap could now


be possibly filled by the 3-Fluid nozzle system.


For more information ✔ at www.scientistlive.com/eurolab


Micheal Whelehan is Product Specialist Encapsulation & Spray Drying, and


Philipp John is Group Project Manager Encapsulation & Spray Drying, BUCHI Labortechnik AG, Flawil,


Switzerland. www.buchi.com. Nurhan


T Dunford is Professor at Oklahoma State University, Stillwater, OK, USA.


Ramtoola et al., Expert Opinion in Drug Delivery, 9, 1463-1474 (2012).


2 Mahdi et al., Drying Technology, 26, 816-835 (2008). 3 Rè, Drying Technology, 24, 433-446 (2006).


4 Whelehan et al., Journal of Microencapsulation, 28, 669-688 (2011). ), a monoclonal antibody (Fig. 3c), and a


5 Dunford & Legako, Journal of Food Science 75, 394-400 (2010) 6 http://www.buchi.com/Mini_Spray_Dryer_B-290_Accesso.182.0.html < 7


http://www.rcsi.ie/technologiesforlicense


“The food industry has been by far the biggest benefactor of spray drying. ”


Fig. 3. Microscopic images displaying core-shell microcapsules produced using a 3-Fluid nozzle on a BÜCHI spray dryer. (a) Fish oil encapsulated within a whey protein membrane5 visualization of the separate core and shell phases7


. (b) Incorporation of a fluorescent marker within the core material to enable , and (c) monoclonal antibody trastuzumab encapsulated within chitosan.


www.scientistlive.com


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