chromatography • spectroscopy 29
highly specific and sensitive mass- spectrometry technique, can detect and quantify analytes from plasma, serum and other biological samples. A multiplex assay can simultaneously measure multiple analytes, such as proteins, peptides, metabolites and lipids.
“Te ability to quickly and accurately measure, monitor and analyse a large number of protein biomarkers in a single test has important applications for understanding human diseases and developing new clinical diagnostics,” said John E Blume, chief science officer of Applied Proteomics. “Agilent’s innovation in mass spectrometry is an important part of this collaboration as we work together to expand the capabilities of multiplex protein assays.”
Applied Proteomics specialises in a proteomics platform solution with mass spectrometry-based systems control and computational expertise to rapidly collect, process and analyse proteins.
Improved stability Meanwhile Analytik Jena has extended its latest generation of double-beam spectrophotometers to include the SPECORD 50 PLUS. Tis new dual-beam UV/Vis photometer is ideal for the spectral range from 190 to 1100 nm and combines high energy throughput with improved stability. Quartz-
coated, premium encapsulated optical components guarantee the highest quality, maximum performance and extreme durability.
Te SPECORD 50 PLUS offers the right solution for numerous applications: routine analysis or special application in chemistry, pharmacy, medicine, food control, environment, life science and many other areas.
A number of other devices are also available: SPECORD 200 PLUS with fixed spectral bandwidth – ideal for qualitative and quantitative routine photometric applications; SPECORD 210 PLUS with four variable spectral bandwidths – ideal for measuring solutions and solids with highest demands concerning the optical resolution; and SPECORD 250 PLUS with four variable spectral bandwidths and double monochromator for samples with particularly high absorptions and higher stray light quotient.
Key features of the new spectrophotometer include: no warm-up phase, plug and play; large, easily accessible sample compartment for quick change of samples and accessories; internal holmium oxide filter for automatic wavelength calibration; fast, easy lamp replacement; alternative cell position in front of the detector to measure turbid samples; pre-aligned,
voltage stabilised radiation sources; unparalleled range of accessories for the automation of routine analyses as well as for special applications; and wide sphere of use – including chemistry, pharmacy, life science, medicine, food, and environmental analyses.
Resistive Glass PHOTONIS USA, a leading electro-optic manufacturer, has introduced the DART ion mobility spectrometer (IMS), designed for simplified, fast analysis of solids or liquids to easily detect contaminants or qualify material.
Te IMS can be used in homeland security, pharmaceutical or laboratory applications.
Te spectrometer provides sample analysis in a two-stage IMS configuration. High resolving power (64-150) is achieved using PHOTONIS patented
Resistive Glass technology which is currently used in other IMS applications, and a new photo- etched ion gate that provides the rapid pulsing necessary to produce spectra with high resolving power.
Te sample inlet utilises IonSense’s patented direct analysis in real time (DART) technology to ionise solid, liquid and gas phase analytes with no special sample preparation.
Excellims’ new high-performance ion mobility instrument E
xcellims has added the new IA3100 model to its line of high-performance ion mobility spectrometry (HPIMS).
HPIMS offers high resolution separation based on
an analyte’s gas phase ion mobility. The technology delivers resolving power that complements modern chromatography and mass spectrometry analysis. The IA3100 hyphenated chromatography-ion mobility spectrometer system is used for the most comprehensive analytical separation of complex samples. The benefits of HPIMS are realised through simultaneous separation and detection. Excellims says it provides standalone and transportable configurations
with flexible sampling accessories that are a practical solution for laboratory, process and field use. “The superior separation speed and impressive 70+
resolving power of HPIMS make it an ideal tool for high throughput analysis and screening,” notes the company. It can be combined with, or in place of, chromatography and mass spectrometry. “HPIMS is well suited for applications requiring
robust analysis that need to be performed in challenging environments, typically found outside of a lab.
HPIMS provides standalone chemical analysis
at lower costs and without added complexity. Excellims GA2100 DirectSpray and RA4100 Research
HPIMS instruments are used throughout the world in government and other organisations identifying contamination and detecting counterfeits in food and drug products. Applications in pharmaceutical and chemical
manufacturing processes include: reaction monitoring, cleaning verification and content uniformity. In addition, food and drug inspection plus explosives and controlled- substance detection are further applications for the novel capabilities of HPIMS. Founded in 2005, Excellims Corporation developed
the HPIMS technology to answer the needs of government and industry for better alternatives to detecting chemical substances with speed and accuracy.
“The increased ion transfer results in a 6-10 fold increase ion transmission into the mass spectrometer.”
| Page 2
| Page 3
| Page 4
| Page 5
| Page 6
| Page 7
| Page 8
| Page 9
| Page 10
| Page 11
| Page 12
| Page 13
| Page 14
| Page 15
| Page 16
| Page 17
| Page 18
| Page 19
| Page 20
| Page 21
| Page 22
| Page 23
| Page 24
| Page 25
| Page 26
| Page 27
| Page 28
| Page 29
| Page 30
| Page 31
| Page 32
| Page 33
| Page 34
| Page 35
| Page 36
| Page 37
| Page 38
| Page 39
| Page 40
| Page 41
| Page 42
| Page 43
| Page 44
| Page 45
| Page 46
| Page 47
| Page 48
| Page 49
| Page 50
| Page 51
| Page 52