Nutrition Assessment Box 2.16 (cont.) Pharmacological Treatment of Obesity13


• Weight loss: ○ Above diet and lifestyle alone: 6.6 kg (14.5 lb) ○ Mean weight loss: 6.6% • Common side effects:


Naltrexone (N)/bupropion (b)


• Brand name: Contrave • Principal action: Suppresses food intake through the brain, especially in reward/craving sites


• Dosage: 8 mg (N)/90 mg (b), tablets BID (high dose: 32 mg/ 360 mg; two tablets four times daily)


• Weight loss: ○ Mean weight loss: 4.8%


• Common side effects: Nausea, constipation, headache, vomiting, dizziness; has a boxed warning to alert health pro- fessionals that because it contains bupropion, clients have an increased risk of suicidal thoughts and behaviors associated with antidepressant drugs.


Liraglutide (rDNA origin) injection


• Brand name: Saxenda • Principal action: GLP-1 agonist • Dosage: 3.0 mg injectable daily


• Weight loss: ○ Above diet and lifestyle alone: 5.8 kg (12.8 lb) ○ Mean weight loss: 8%


• Common side effects: Nausea, vomiting, pancreatitis References


1. Academy of Nutrition and Dietetics. Nutrition Ter- minology Reference Manual (eNCPT): Dietetics Language for Nutrition Care. http://ncpt.webauthor .com. Accessed January 9, 2016.


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Insomnia, dry mouth, constipation,


paraesthesia, dizziness, dysgeusia; phentermine may increase blood pressure; topiramate may sedate and even mood


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