35. LifeCycle Project-Maternal Obesity and Childhood Outcomes Study Group, Voerman E, Santos S, et al. Association of gestational weight gain with adverse maternal and infant outcomes. JAMA. 2019;321(17):1702-1715. doi:10 . 1001 / jama . 2019 . 3820
36. Wang L, Zhang X, Chen T, et al. Association of gestational weight gain with infant morbidity and mortality in the United States. JAMA Netw Open. 2021;4(12):e2141498. doi:10 . 1001 / jamanetworkopen . 2021 . 41498
37. Catalano PM, Shankar K. Obesity and pregnancy: mechanisms of short term and long term adverse consequences for mother and
child.BMJ. 2017;356:j1. doi:10 . 1136 / bmj . j1
38. Greendale GA, Sternfeld B, Huang M, et al. Changes in body composition and weight during the menopause transition. JCI Insight. 2019;4(5):e124865. doi:10 . 1172 / jci . insight . 124865
39. Gavin KM, Kohrt WM, Klemm DJ, Melanson EL. Modulation of energy expenditure by estrogens and exercise in women. Exerc Sport Sci Rev. 2018;46(4):232-239. doi:10 . 1249 / jes . 0000000000000160
40. Liu P, Ji Y, Yuen T, et al. Blocking FSH induces thermogenic adipose tissue and reduces body fat. Nature. 2017;546(7656):107-112. doi:10 . 1038 / nature22342
41. Batsis JA, Villareal DT. Sarcopenic obesity in older adults: aetiology, epidemiology and treatment
strategies.Nat Rev Endocrinol. 2018;14(9):513-537. doi:10 . 1038 / s41574 - 018 - 0062 - 9
42. Atkins JL, Whincup PH, Morris RW, Lennon LT, Papacosta O, Wannamethee SG. Sarcopenic obesity and risk of cardiovascular disease and mortality: a population-based cohort study of older men.J Am Geriatr Soc. 2014;62(2):253-260. doi:10 . 1111 / jgs . 12652
43. Norris T, Cole TJ, Bann D, et al. Duration of obesity exposure between ages 10 and 40 years and its relationship with cardiometabolic disease risk factors: a cohort study. PLoS Med. 2020;17(12):e1003387. doi:10 . 1371 / journal . pmed . 1003387
44. Bray GA, Heisel WE, Afshin A, et al. The science of obesity management: an Endocrine Society scientific statement. Endocr Rev. 2018;39(2):79-132. doi:10 . 1210 / er . 2017 - 00253
45. Afshin A, Forouzanfar MH, Reitsma MB, et al. Health effects of overweight and obesity in 195 countries over 25 years.N Engl J Med. 2017;377(1):13-27. doi:10 . 1056 / NEJMoa1614362
46. Calle EE, Thun MJ, Petrelli JM, Rodriguez C, Heath CW Jr. Body-mass index and mortality in a prospective cohort of U.S. adults. N Engl J Med. 1999;341(15):1097-1105. doi:10 . 1056 / NEJM199910073411501
47. Flegal KM, Kit BK, Orpana H, Graubard BI. Association of all-cause mortality with overweight and obesity using standard body mass index categories: a systematic review and meta-analysis. JAMA. 2013;309(1):71-82. doi:10 . 1001 / jama . 2012 . 113905
48. Chan JM, Rimm EB, Colditz GA, Stampfer MJ, Willett WC. Obesity, fat distribution, and weight gain as risk factors for clinical diabetes in men. Diabetes Care. 1994;17(9):961-969. doi:10 . 2337 / diacare . 17 . 9 . 961
49. Colditz GA, Willett WC, Rotnitzky A, Manson JE. Weight gain as a risk factor for clinical diabetes mellitus in women. Ann Intern Med. 1995;122(7):481-486. doi:10 . 7326 / 0003 - 4819 - 122 - 7 - 199504010 - 00001
50. Magkos F, Fraterrigo G, Yoshino J, et al. Effects of moderate and subsequent progressive weight loss on metabolic function and adipose tissue biology in humans with obesity. Cell Metab. 2016;23(4):591-601. doi:10 . 1016 / j . cmet . 2016 . 02 . 005
51. Elagizi A, Kachur S, Carbone S, Lavie CJ, Blair SN. A review of obesity, physical activity, and cardiovascular disease. Curr Obes Rep. 2020;9(4):571-581. doi:10 . 1007 / s13679 - 020 - 00403 - z
52. Avgerinos KI, Spyrou N, Mantzoros CS, Dalamaga M. Obesity and cancer risk: emerging biological mechanisms and
perspectives.Metabolism. 2019;92:121-135. doi:10 . 1016 / j . metabol . 2018 . 11 . 001
53. Kramer CK, Zinman B, Retnakaran R. Are metabolically healthy overweight and obesity benign conditions? A systematic review and meta-analysis. Ann Intern Med. 2013;159(11):758-769. doi:10 . 7326 / 0003 - 4819 - 159 - 11 - 201312030 - 00008
54. Hansen L, Netterstrøm MK, Johansen NB, et al. Metabolically healthy obesity and ischemic heart disease: a 10-year follow-up of the Inter99 Study. J Clin Endocrinol Metab. 2017;102(6):1934-1942. doi:10 . 1210 / jc . 2016 - 3346
55. Ortega FB, Cadenas-Sanchez C, Migueles JH, et al. Role of physical activity and fitness in the characterization and prognosis of the metabolically healthy obesity phenotype: a systematic review and meta-analysis. Prog Cardiovasc Dis. 2018;61(2):190- 205. doi:10 . 1016 / j . pcad . 2018 . 07 . 008
56. Lavie CJ, De Schutter A, Parto P, et al. Obesity and prevalence of cardiovascular diseases and prognosis—the obesity paradox updated. Prog Cardiovasc Dis. 2016;58(5):537-547. doi:10 . 1016 / j . pcad . 2016 . 01 . 008
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