CONTENTS
Research Highlights 3 CELL BIOLOGY & IMMUNOLOGY
17 CHEMISTRY & MATERIALS 31 GENETICS & DISEASE
Following the toxin trails | Slow twitch, fast twitch | Spotting the invaders | The twists and turns of tumor treatment | A collective effort | Knowing what they want to be in life | Monocytes are not all the same | Patrolling skin for pathogens | A new breath of life | Surveying survival outcomes in liver cancer | Follow the leader | System reboot | In search of risky rearrangements
As light as silk | Tubular probes | A sticky problem | A flexible filter | A ferroelectric boost | Bit by bit | The small stuff matters | As good as gold | Pillars of the assembly | Soaking up the atmosphere | A clear choice | When additives are good | A resonant improvement
A way to maintain pluripotency | Aggravating tumor aggressiveness | Speeding up evolution | Delayed polyadenylation of maternal mRNA | Battle of the sex chromosomes | Breaking into liver cancer | Cooperative partners | Sorting through the damage | Driving neuronal differentiation | Malignant rearrangements | A big role for small RNAs | Cause of dissemination | Markers for bone-fusion disease | The two faces of a cancer signal | Seeing the light | Sabotaging cellular stability | Bringing battlers to the tumor
49 PHYSICAL & LIFE SCIENCE TECHNOLOGIES 69 ENGINEERING & NANOTECHNOLOGY
Wearing your heart condition on your sleeve | In the crossfire | A simulator for liver blood vessels | Looking good | Germ killers | Temperature-regulated release | Quick blood testing | Magnetic memories | Getting better at the age guessing game | Theory goes big | A subtle switch | Natural therapy | Heightened accuracy | Nestled in | Modeling the mind | Bubble power | The right tool for the right job | A faster model for speedier circuits | Integrated laser on silicon is looking good
Feel the pressure | Perfecting plastic | One stone, two birds | Sizing up cells | Probing for interactions | Harnessing hotspots | Coupled duo | Seamless memory | Light-and-heat therapy | Better connected | A coating protocol | Heart-to- heart | Diamonds are a probe’s best friend | Direct arene amination | Golden atoms
Features and Innovations 86 Self-assembling
biomimetic nanostructures
87 Celebrating Singapore’s young 89 Video-on-demand goes one step
scientific talent further
A*STAR Research
www.astar-research.com
A*STAR Research is a publication of the Agency for Science, Technology and Research (A*STAR)—Singapore’s lead government agency for fostering world-class scientific research.
A*STAR Research is published twice a year, presenting research highlights and feature articles. All articles are first published online on the A*STAR Research website and available free to all readers. Register online to receive the table of contents by email as each biweekly online issue is published.
© 2012 A*STAR. This publication may be reproduced in its original form for personal use only. Modification or commercial use without prior permission from the copyright holder is prohibited.
Editorial Agency for Science, Technology and Research 1 Fusionopolis Way, #20-10 Connexis North Tower Singapore 138632, Singapore
Editor-in-Chief Editorial Board
Charles Zukoski
Pernille Rorth David Srolovitz Huck Hui Ng Colin Stewart Andy Hor
Managing Editor Administrative Assistant ISSN 2010-0531
Kostas Repanas Lay Hoon Tan
91 Nanomedicine breakthrough 92 The MicroKit wins Silver
hailed as ‘world changing’ Innovation Award
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