7 Iscaguard DPM ® Iscaguard® DPM is a blend of diazolidinyl urea,


methylparaben and propylparaben in propylene glycol giving the advantages of broad-spectrum antimicrobial protection and the ease of liquid handling.


Iscaguard® DPM is effective at 0.3 – 1.0% in many


formulation types, and is compatible with proteins and anionic, cationic and nonionic emulsifiers. It is an ideal preservative in both rinse-off and leave-on products and is particularly suitable for emulsions with a low (<25%) oil phase.


Iscaguard® DPM retains its activity over the range pH 3.0 – 7.0.


Regulatory status Iscaguard®


DPM is permitted for use in personal care


products in the European Union (maximum 1.66%) and the USA (maximum 1.66%). Iscaguard®


DPM is not


permitted for use in Japan. INCI name: propylene glycol, diazolidinyl urea, methylparaben, propylparaben.


Using Iscaguard® Iscaguard®


DPM DPM is soluble in water to approximately 1.0%


and is readily incorporated into most product types. In hot emulsification processes it is advisable to add the product during the cooling stage as it should not be exposed to temperatures above 60°C for prolonged periods.


Table 15 Solubility of Iscaguard® Water


Propylene glycol Butylene glycol


Table 16 Antimicrobial activity of Iscaguard® Microorganism


Pseudomonas aeruginosa Escherichia coli Proteus vulgaris


Staphylococcus aureus Bacillus cereus


Enterococcus faecium Candida albicans Saccharomyces cerevisiae Aspergillus niger DPM (% w/w @ 25°C)


Approx. 1.0% Miscible


Approx. 4.5% DPM


Minimum inhibitory concentration (%)


0.30 0.25 0.25


0.25 0.30 0.25


0.45 0.20


0.40


Table 18 Antimicrobial activity of Iscaguard® Microorganism


Pseudomonas aeruginosa Escherichia coli Proteus vulgaris


Staphylococcus aureus Bacillus cereus


Enterococcus faecium Candida albicans Saccharomyces cerevisiae Aspergillus niger DPM2


Minimum inhibitory concentration (%)


0.25 0.20 0.25


0.20 0.30 0.25


0.40 0.25


0.40


ISCA Iscaguard®


Preservative Blends Iscaguard DPM2 ® Iscaguard® DPM2 is a blend of diazolidinyl urea,


methylparaben and propylparaben in propylene glycol giving the advantages of broad-spectrum antimicrobial protection and the ease of liquid handling.


Iscaguard® DPM2 is effective at 0.3 – 1.0% in many


formulation types, and is compatible with proteins and anionic, cationic and nonionic emulsifiers. It is particularly suitable for use in emulsions with a high (>25%) oil phase.


Iscaguard® DPM2 retains its activity over the range pH 3.0 – 7.0.


Regulatory Status Iscaguard®


DPM2 is permitted for use in personal care


products in the European Union (maximum 2.50%) and the USA (maximum 2.50%). Iscaguard® DPM2 is not permitted for use in Japan. INCI name: propylene glycol, diazolidinyl urea, methylparaben, propylparaben.


Using Iscaguard® Iscaguard®


DPM2 DPM2 is soluble in water to approximately


0.5% and is readily incorporated into most product types. In hot emulsification processes it is advisable to add the product during the cooling stage as it should not be exposed to temperatures above 60°C for prolonged periods.


Table 17 Solubility of Iscaguard® Water


Propylene glycol Butylene glycol


DPM2 (% w/w @ 25°C)


Approx. 0.5% Miscible


Approx. 5.0%


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