11 Iscaguard MPB ® Iscaguard® MPB is an optimised blend of methylparaben,


propylparaben and bronopol in phenoxyethanol giving the advantages of broad-spectrum antimicrobial protection and ease of liquid handling. At typical use concentrations of 0.3 – 0.8%, Iscaguard®


MPB is highly effective in a broad range of


ISCA Iscaguard®


Preservative Blends


Table 25 Solubility of Iscaguard® Water


Propylene glycol Butylene glycol Glycerine


MPB exhibits excellent preservative efficacy,


and is non-irritating to eyes, skin or mucous membranes. Iscaguard®


formulation types, but is particularly successful in sun care products (based both on UV absorbers and inorganic sunscreen agents), and in moist tissue wipes. Both of these product types are usually very difficult to preserve. Iscaguard®


MPB is compatible with most types of personal


care ingredients and its use is strongly recommended in nonionic systems where parabens alone show reduced activity. Tests have shown that Iscaguard®


MPB


significantly reduces and often completely eliminates the paraben inactivation effect exhibited by some nonionic emulsifiers. More details are available on request.


Regulatory Status Iscaguard®


MPB is permitted for use in personal care


products in the European Union (maximum 1.33%) and the USA (safe as used). The product is not permitted in Japan.


INCI name: phenoxyethanol, methylparaben, propylparaben, 2-bromo-2-nitropropane-1,3-diol.


Using Iscaguard® Iscaguard®


MPB MPB is soluble in water to approximately


0.5%. Heating to 40°C may be required, however, in order to dissolve the product more rapidly in aqueous solutions. Alternatively, Iscaguard®


MPB may be


pre-dissolved in one of the other formulation components, e.g. surfactant or organic solvent. Iscaguard®


MPB should be added during the cooling stage


(below 40°C, where possible) of hot processes to avoid preservative loss.


Amines have the potential to form nitrosamines in products, and the presence of bronopol may increase this potential. It is recommended that Iscaguard® used in formulations containing amines.


MPB is not Aspergillus niger 0.175


Table 26 Antimicrobial activity of Iscaguard® Microorganism


Pseudomonas aeruginosa Escherichia coli Proteus vulgaris


Staphylococcus aureus Enterococcus faecium Bacillus cereus


Candida albicans Saccharomyces cerevisiae


MPB (% w/w @ 25°C)


Approx. 0.5% Miscible Miscible 10%


MPB


Minimum inhibitory concentration (%)


0.07 0.07 0.07


0.09 0.09 0.08


0.175 0.14


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