ISCA Iscaguard® Iscaguard MIT ®


Iscaguard is a safe, broad spectrum bactericide for the preservation of leave-on and rinse-off products. Iscaguard MIT is a particularly suitable as replacement for formaldehyde donors in leave-on applications such as skin care formulations and sun care formulations, Zinc pyrithione-based antidandruff shampoos, high pH surfactant systems and high pH liquid cleaners. Iscaguard MIT provides formulators with a non formaldehyde-releasing bactericidal solution which is effective at very low use levels. Iscaguard MIT is also compatible with existing fungicides like parabens and is more stable in difficult to preserve high pH formulations.


INCI Name: Methylisothiazolinone


Regulatory Status Isacaguard MIT is supported by extensive toxicology studies and global regulatory dossiers and is expected to have global approvals for use in cosmetics at the time of printing.


Using Iscaguard MIT Iscaguard MIT preservative should be added as the last ingredient and at the lowest temperature (≤ 45°C if possible). Since the components of personal care formulations vary considerably and may impact on the effect of preservatives, we urge each manufacturer to confirm the efficacy and stability of Iscaguard MIT in use. The recommended use level is 0.05% - 0.1% (48 - 95 ppm of active ingredient) as supplied. At low contamination risk and low detergent or protein content; 0.01-0.05%


At medium contamination risk, medium detergent or protein content; 0.05 - 0.1%


Table 38 Solubility of Iscaguard MIT (%w/w @ 25ºc)


Water


Propylene Glycol Butylene Glycol


Miscible Miscible


Miscible


Table 39 Antimicrobial activity of Iscaguard MIT Microorganism


Pseudomonas aeruginosa Escherichia coli Proteus vulgaris


Staphylococcus aureus Bacillus cereus


Enterococcus faecium Candida albicans


Saccharomyces cerevisiae Aspergillus niger


Preservative Blends


20


Minimum inhibitory concentration(%)


0.04 0.04 0.02 0.03 0.02 0.04 0.32 0.35 0.16


The MIC-values have been determined in dilution assays: Bacteria: 24-48 h at 37ºC Yeast/Fungi: 48-72 h at 28ºC


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