ISCA Iscaguard®


Iscaguard IU and Iscaguard DU


® ® Iscaguard® IU, imidazolidinyl urea and Iscaguard® DU,


diazolidinyl urea, are both fine white, virtually odourless powders with excellent activity against gram-negative and gram-positive bacteria.


Both are extremely soluble in water and do not usually require heating to dissolve. Neither product should be exposed to temperatures greater than 40ºC and should be added during the cooling stage of hot processes.


Regulatory Status Iscaguard®


DU is permitted in the US (maximum 0.5%)


and Europe (maximum 0.5%) but it is not permitted in Japan. Iscaguard®


IU is permitted in the US (maximum 0.5%)


and Europe (maximum 0.5%). It is permitted in Japan for use in rinse-off products only up to a maximum of 0.3%.


Table 7


Solubility of Iscaguard® Water


Propylene glycol Butylene glycol


Table 8 Antimicrobial activity of Iscaguard® Microorganism


Pseudomonas aeruginosa Escherichia coli Proteus vulgaris


Staphylococcus aureus Bacillus cereus


Enterococcus faecium Candida albicans Saccharomyces cerevisiae Aspergillus niger Table 9


Solubility of Iscaguard® Water


Glycerine Mineral oil


IU (% w/w @ 25°C)


65% 48%


< 0.01%


Using Iscaguard CMI® On a weight/weight basis, this isothiazolinone blend is probably the most effective broad-spectrum preservative available for personal care products and it is particularly useful in detergent-based products, such as shower gels, bath foams and shampoos.


DU


Minimum inhibitory concentration (%)


0.10 0.12 0.13


0.08 0.10 0.11


0.70 0.20


0.30


Table 11 Antimicrobial activity of Iscaguard® Microorganism


Pseudomonas aeruginosa Staphylococcus aureus Candida albicans Aspergillus niger


Iscaguard CMI ® Iscaguard® CMI is a 1.5% solution of a blend of


chloromethyl and methyl isothiazolinone in a strictly controlled ratio of 3:1. The mixture is stabilised with magnesium chloride and magnesium nitrate.


DMD


Minimum inhibitory concentration(%)


0.05


0.025 0.1


0.15 DU (% w/w @ 25°C)


70% 40%


0.25% Iscaguard® DMD is a 55% solution of dimethyl dimethylol


hydantoin(DMDMH) in water. It has excellent broad-spectrum activity and is effective at low use concentrations, from 0.15-0.4%.


Using Iscaguard® Iscaguard®


DMD DMD has excellent solubility in water and


should be added during the cooling stage of hot processes.


Regulatory Status Iscaguard®


DMD is approved for use in the US, Europe (up


to a maximum of 0.6%) and Japan for rinse-off products only, up to a maximum concentration of 0.3%.


Preservative Blends


Table 10 Antimicrobial activity of Iscaguard® Microorganism


Pseudomonas aeruginosa Escherichia coli Proteus vulgaris


Staphylococcus aureus Bacillus cereus


Enterococcus faecium Iscaguard DMD ®


4


IU


Minimum inhibitory concentration(%)


0.10 0.13 0.13


0.10 0.10 0.10


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