ISCA Iscaguard® Iscaguard Preservative Blends ® Iscaguard DPE ® Iscaguard® DPE is a blend of phenoxyethanol and


methyldibromo glutaronitrile giving the advantages of broad-spectrum antimicrobial protection and the ease of liquid handling.


Iscaguard® DPE is effective at 0.1 – 0.3% in many


formulation types, and is compatible with proteins and anionic, cationic and nonionic emulsifiers. Iscaguard®


DPE is formaldehyde-free and retains its activity over the range pH 4.0 – 8.0.


Regulatory status Iscaguard®


DPE is permitted for use in rinse-off products


in the European Union (maximum 0.125%) and the USA (maximum 0.125%). Iscaguard®


DPE is not permitted for


use in Japan. INCI name: phenoxyethanol, methyldibromo glutaronitrile.


Using Iscaguard® Iscaguard®


DPE DPE is soluble in water to approximately 0.4%,


but it is advisable to pre-dissolve the product in one of the non-aqueous formulation components prior to addition. This will avoid the need to heat Iscaguard®


as the product should not be exposed to temperatures above 40°C for prolonged periods.


DPE,


Pseudomonas aeruginosa Escherichia coli Proteus vulgaris


Staphylococcus aureus Bacillus cereus


Enterococcus faecium Candida albicans Saccharomyces cerevisiae Aspergillus niger


Table 14 Antimicrobial activity of Iscaguard® Microorganism


DPE


Minimum inhibitory concentration (%)


0.07


0.025 0.02


0.02 0.02


0.025


0.0125 0.01


0.035 Iscaguard® DPE may discolour on exposure to UV light and should be stored in the original container.


Table 13 Solubility of Iscaguard® Water


Propylene glycol Butylene glycol


DPE (% w/w @ 25°C)


Approx. 0.4% Miscible Miscible


Preservative Blends


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