21 Iscaguard PEG ®
Iscaguard PEG is a liquid based cosmetic preservative based on a synergistic blend of alkene and phenyl glycols. This synergistic blend affects interfacial surface tensions of cell membranes of microorganisms, improving preservative efficacy. Iscaguard PEG has a broad, balanced spectrum effect against bacteria, yeasts, mould and fungi. Iscaguard PEG is also compatible with existing fungicides like parabens and is more stable in difficult to preserve high pH formulations.
INCI Name: Phenoxyethanol, Alkene Glycol.
Regulatory Status Isacaguard PEG is GRAS approved in Australia AICS; TGA, Canada; listed DSL, Japan; ENCS(no:4041) and International approved in acc EU, ASEAN Cosmetics directive to max 1.5%
Using Iscaguard PEG Iscaguard PEG preservative is stable to hydrolysis temperatures and pH. As a result the good stability of Iscaguard PEG it is highly suited to forming stable dispersions at low temperatures and up to a pH of 13. In practice emulsions can be preserved with addition levels as low as 0.4% Iscaguard PEG can be effectively used in products containing natural ingredients although a contact time of 48 hours is recommended to eliminate microorganisms introduced through contaminated raw materials. Good manufacturing practice and the use of raw materials with low bacterial counts are an important parameter in perfect products.
Pseudomonas aeruginosa Escherichia coli Proteus vulgaris
Staphylococcus aureus Bacillus cereus
Enterococcus faecium Candida albicans
Saccharomyces cerevisiae Aspergillus niger
Table 40 Solubility of Iscaguard PEG (%w/w @ 25ºc)
Water
Propylene Glycol Butylene Glycol
Table 41 Antimicrobial activity of Iscaguard PEG Microorganism
Miscible Miscible
Miscible
ISCA Iscaguard®
Preservative Blends
Minimum inhibitory concentration(%)
0.22 0.44 0.29 0.47 0.26 0.42 0.32 0.44 0.23
The MIC-values have been determined in dilution assays: Bacteria: 24-48 h at 37ºC Yeast/Fungi: 48-72 h at 28ºC
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