ISCA Iscaguard® Iscaguard PFA ® Iscaguard® PFA is a “preservative free additive” with a


synergistic combination of multifunctional cosmetic raw materials with broad-spectrum antimicrobial protection. Iscaguard®


PFA may be classed as a “preservative free


system”. This system represent an alternative to traditional cosmetic preservatives allowing self-preserving formulations thereby reducing irritant and sensitizing potentials.


Iscaguard® 4 to 8. Typical use levels for Iscaguard®


PFA is stable and active over a pH range of PFA range from


0.5% to 1.5%. It is synergistic in combination with chelating agents.


Regulatory Status Iscaguard®


PFA is permitted worldwide for use in both leave-on and rinse-off personal care products.


EU – allowed without restriction in all products (not listed on Annex VI)


USA – allowed without restriction in all products Japan – allowed without restrictions in all products


Phenethyl alcohol is judged safe for use in cosmetics to 1.0%. Based on the CIR review for phenethyl alcohol and the good toxicity assessment for caprylyl glycol Iscaguard®


PFA should be safe in cosmetics up to 1.8%


INCI name: phenethyl alcohol and caprylyl glycol Using Iscaguard®


PFA Iscaguard® PFA is particularly suitable for emulsions,


oil and surfactant based formulations and may be used in aqueous formulations upto its solubility limit i.e. 0.6%. Iscaguard®


PFA can be added to formulation at


temperatures up to 80ºC, prolonged heating at elevated temperatures is not recommended.


Physical/Chemical Characteristics Caprylyl glycol


35 – 45%


Phenethyl alcohol 55 – 65% Appearance


Odor


Clear colorless liquid Mild rose-like odor


Density 0.98 g/ml pH (0.5% in water) 4.6


Table 35 Solubility of Iscaguard®


Water Ethanol


Propylene glycol Butylene glycol


Table 36 Antimicrobial activity of Iscaguard®


Microorganism


Pseudomonas aeruginosa Escherichia coli


Proteus vulgaris Staphylococcus aureus


Bacillus subtilis Enterococcus hirae Candida albicans Saccharomyces cerevisiae Aspergillus niger PFA


Minimum inhibitory concentration(%)


0.10 - 0.30 0.10 – 0.20


0.175 – 0.2 0.20 0.20


0.175 – 0.25 0.10


0.175 PFA (% w/w @ 25ºC)


0.6% >50% >50% >50%


Preservative Blends


18


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