42 ANTI-AGING
at 0, Fig 9). Liftonin develops its full efficacy after only 4 weeks although it has to be admitted that no later time points were investigated. Liftonin-Xpert Eco needs more time to manifest its efficacy as it influences skin biology at a deeper level to promote collagen expression, which obviously takes a while but gives the best results. In view of these results, it is apparent that a combination of these three active ingredients would serve as a powerful supplement in cosmetic formulations designed for the initiation of anti-wrinkle treatment that would provide impressive instant results combined with collagen stabilization and a long-term collagen buildup.
PC
References 1 Body Composition in Animals and Man. Washington, D.C.: National Academy of Sciences; 1968.
2 Bänziger S, Obermayer B. Physical active ingredients for Wrinkle reduction. SOFW Journal, 2012.
3 Keary C. Characterization of METHOCEL cellulose ethers by aqueous SEC with multiple detectors. Carbohydrate Polymers, 2000; 45:293-303.
4 Cheng KC, Demirci A, Catchmark JM. Pullulan: biosynthesis, production, and applications. Appl Microbiol Biotechnol, 92:29-44.
5 Shoshana (Malis) Arad MA, Ephraim Cohen. The potential production of sulfated polysaccharides from Porphyridium. Plant and Soil 1985; 89: 117 - 127.
6 Heinemann S, Thibaud C, Desimone F. Bio- inspired silica–collagen materials: applications and perspectives in the medical field. Biomaterials Science 2013; 1:
Formulation 1: Ageless Eye Serum Phase Substance 1
Water demin.1 LIFTONIN®
2 Optigel WX3 Optigel CL3 Solagum AX4 3 4 5 TEGO Pep 4-175 Verstatil PC5 Eldew PS-203R6 Citric Acid solution 10%1 -XPRESS2 n LIFTONIN-XPRESS n LIFTONIN n LIFTONIN-XPERT Eco
120 100 80 60 40 20 0
0 2 4 6 8 time (weeks) 10 12 14
Figure 9: Progression of efficacy based on study results. By means of continuous use of the active ingredients, the anti-wrinkle effect of Liftonin-Xpress is manifested immediately, while the effects of Liftonin become apparent within 4 weeks and those of Liftonin-Xpert Eco within 3 months in accordance with their individual modes of action. Continuous use of the latter agents will maintain achieved benefits at a high level.
7 Natarajan V, Krithica N, Madhan B, Sehgal PK. Preparation and properties of tannic acid cross- linked collagen scaffold and its application in wound healing. J Biomed Mater Res B Appl Biomater, 2013; 101:560-567.
8 Baroni T, Bodo M, D’Alessandro A, Conte C, Calvitti M, Muzi G, et al. Silica and its antagonistic effects on transforming growth factor-beta in lung fibroblast extracellular matrix production. J Investig Med, 2001; 49:146-156
9 Kumar KJ, Vani MG, Wang SY, Liao JW, Hsu LS,
INCI Name USA Water
Hydroxypropyl Methylcellulose, Pullulan, Porphyridium Cruentum Extract
Bentonite, Xanthan Gum Magnesium Aluminum Silicate Acacia Senegal Gum, Xanthan Gum
Tetrapeptide-21, Glycerin, Butylene Glycol, Water
Phenoxyethanol, Caprylyl Glycol
Phytosteryl/Octyldodecyl Lauroyl Glutamate Citric Acid, Water
Production: Prepare half of the water / Add LIFTONIN®
% w/w 84.20 2.00
1.00 4.00
0.30 5.00
1.10 0.20 2.20
- XPRESS while stirring; let it swell for about
10 minutes, the phase must be free of lumps / Take the other part of the water and add Optigel WX and CL while stirring / Homogenise for 10 minutes and add the whole gel to the water and LIFTONIN®
- XPRESS mixture while stirring / Continue stirring till a homogenous gel appears / Add
the remaining ingredients while stirring; homogenise Properties:
Appearance Light brownish gel pH-value 6.5-7.0
Suppliers: 1 Several 2 Rahn AG 3 BYK Chemie 4 Seppic 5 Evonik Industries 6 Ajinomoto PERSONAL CARE NORTH AMERICA
Yang HL, et al. In vitro and in vivo studies disclosed the depigmenting effects of gallic acid: a novel skin lightening agent for hyperpigmentary skin diseases. Biofactors 2013; 39:259-270
10 Hettwer S, Besic Gyenge E, Suter B, Obermayer B. Alabaster like skin with tannins and botanical silicon. SOFW Journal, 2017.
11 Hettwer S, Bänziger S, Suter B, Obermayer B. A new era of collagen management. SPC 2016; 89:81-85.
12 Van Wyk BE, Van Oudtshoorn B, Gericke N. Medicinal Plants of South Africa. In. Edited by Publication B; 1997.
13 Pather N, Kramer B. Bulbine natalensis and Bulbine frutescens promote cutaneous wound healing. J Ethnopharmacol 2012; 144:523-532
14 Pather N, Viljoen AM, Kramer B. A biochemical comparison of the in vivo effects of Bulbine frutescens and Bulbine natalensis on cutaneous wound healing. J Ethnopharmacol, 2011;133:364-370.
15 Jettanacheawchankit S, Sasithanasate S, Sangvanich P, Banlunara W, Thunyakitpisal P. Acemannan stimulates gingival fibroblast proliferation; expressions of keratinocyte growth factor-1, vascular endothelial growth factor, and type I collagen; and wound healing. J Pharmacol Sci 2009; 109:525-531.
16 Xing W, Guo W, Zou CH, Fu TT, Li XY, Zhu M, et al. Acemannan accelerates cell proliferation and skin wound healing through AKT/mTOR signaling pathway. J Dermatol Sci 2015; 79:101-109,.
17 Sierra-Garcia GD, Castro-Rios R, Gonzalez- Horta A, Lara-Arias J, Chavez-Montes A. Acemannan, an extracted polysaccharide from Aloe vera: A literature review. Nat Prod Commun, 2014; 9:1217-1221.
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