COVER STORY: SILAB ADVERTISEMENT FEATURE
Revitalise regeneration for anti-ageing effects
Regeneration is the innate capacity of living beings to repair themselves by the beneficial use of their own resources. Preserving this property is a key strategy for ageing well and in good health. Long restricted to the cutaneous system,
regeneration of the skin is now described as a complex process requiring the participation of the vascular system and the immune system. The fibroblast in particular plays a pivotal role
by interconnecting the three biological systems via the secretion of a pool of growth factors. These factors are placed under the term ‘fibroblast- regenerating complex’ and have a positive action not only on the activity of keratinocytes but also on that of immune and endothelial cells.
First-ever modelling Even though this dynamic process exists throughout the entire lifetime, original modelling studies from SILAB Research demonstrated that it is altered with ageing. Through the establishment of scientific
partnerships with two prestigious international research laboratories, SILAB has acquired new technological expertise and has integrated in- house the skills required to develop innovative vascularised models and models of immune cells. This has led to the first-ever demonstration of the depletion of the fibroblast-regenerating complex with age and its harmful effect on the interactions of aged fibroblasts with the cutaneous, vascular and immune systems. Based on these discoveries, SILAB developed
REGENIXIR®, an anti-ageing natural active ingredient that reactivates the cutaneous
D0, BEFORE TREATMENT
Safety & effectiveness of fullerene cosmetics
Up close and personal with self-diagnostic tools
A single ingredient for all types of skin ageing
regeneration by revitalising the interconnectivity of the three biological systems. It thus stimulates the skin’s capacity to synthesise its own growth elixir to improve the overall quality of mature skin.
Depth of wrinkles ++ D21, AFTER TREATMENT Depth of wrinkles +
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Regenerating anti-ageing effect By restoring the capacity of aged fibroblasts to interact with their environment, REGENIXIR® enables a transversal action on the three interconnected systems required for an optimal regeneration process: ■ The cutaneous system: At the epidermis level with a significant improvement of keratinocyte migration (+99%) and epidermal dynamics in vivo ■ The immune system: A significant increase of the differentiation of macrophages into pro- regenerating macrophages (+132%), stimulating matrix restructuring ■ The vascular system: A significant boost in the formation of a vascular network (+55%). This effect involves a significant action on the migration of endothelial cells and their cohesion (+93% and +77%, respectively). In vivo, the visibility of dystrophic microvessels is reduced by 6%, thereby improving cutaneous vascularisation Its cosmetic benefits are multiple. Tested at 2.5% in an emulsion in Caucasian and Asian panels, REGENIXIR® enhances the skin quality as of 21 days of application: ■ Improved skin biomechanical properties, with a significant increase in skin firmness, tonicity and elasticity ■ Reduced appearance of crow’s feet wrinkles ■ Attenuated under-eye circles
■ Revived complexion radiance (effects on reflection, pink colour, olive colour and luminosity) All these benefits continued after 42 days of
treatment and were perceived by the volunteers themselves.
A yeast with health benefits REGENIXIR® meets the market’s and consumers’ requirements in terms of efficacy and safety, but also naturality. Indeed, in the framework of developing this natural active ingredient, SILAB has focused on the yeast Saccharomyces cerevisiae. Widely used in the food industry, this biotech material is also recognised by the medical and scientific community for its countless properties: richness in nutrients, capacity to stimulate energy production and immune defences, etc. SILAB has therefore put the health benefits of
S. cerevisiae to beneficial use by extracting oligo- β-glucans that can restore the interconnectivity of the cutaneous, immune and vascular systems for a regenerating anti-ageing effect.
Combining high efficacy, transversality and safety, REGENIXIR® is an innovative natural active ingredient, enabling the rapid and overall regeneration of mature skin to restore its quality. REGENIXIR® is a patented product, available in aqueous solution (recommended amount: 0.25-2.5%). This active ingredient has a natural origin content of 99% (ISO 16128) and is compliant with international cosmetic regulations (Europe, US, China, Japan, etc.).
February 2022 PERSONAL CARE INGREDIENTS ● FORMULATION ●
MANUFACTURE GLOBAL
7
PC
ZI de la Nau, 19240 Saint-Viance, France Tel.: +33 (0)5 55 84 58 40
silab@silab.fr www.silab.fr
February 2022 PERSONAL CARE
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