ANTI-AGEING
■ Unable to use conventional anti-ageing products ■ Exaggerated damage to common extrinsic factors ■ Itching-scratching cycle-induced barrier impairment ■ Increase genetic susceptibility to intrinsic/extrinsic ageing ■ Skin microinflammation leads to inflamm-ageing
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12 Kwon SH, Lim CJ, Jung J, Kim HJ, Park K, Shin JW et al. The effect of autophagy-enhancing peptide in moisturizer on atopic dermatitis: A randomised controlled trial. J. Dermatol. Treat. 2019. 18;30(6):558–64
13 Pilkington SM, Bulfone-Paus S, Griffiths CEM, Watson REB. Inflammaging & the skin. J. Invest. Dermatol. 2021. 141(4):1087–95
Sensitive skin Sensiti-ageing Premature skin ageing
14 Lee SH, Jeong SK, Ahn SK. An update of the defensive barrier function of skin. Yonsei Med. J. 2006. 47(3):293
■ Increased skin sensitivity ■ Increased vulnerability to environmental factors ■ Becoming more prone to tears & irritation
Figure 3: Sensiti-ageing
comprehensive review. Biomedicine & Pharmacotherapy. 2018. 104:485–95
2 Seo SH, Jung JY, Park K, Hossini AM, Zouboulis CC, Lee SE. Autophagy regulates lipid production & contributes to the sebosuppressive effect of retinoic acid in human SZ95 sebocytes. J. Dermatol Sci. 2020. 98(2):128–36
3 Kim JY, Kim J, Ahn Y, Lee EJ, Hwang S, Almurayshid A, et al. Autophagy induction can regulate skin pigmentation by causing melanosome degradation in keratinocytes & melanocytes. Pigment. Cell. Melanoma Res. 2019. 11;pcmr.12838
4 Lim CJ, Lee Y-M, Kang SG, Lim HW, Shin K-O, Jeong SK, et al. Aquatide activation of SIRT1 reduces cellular senescence through a SIRT1-FOXO1-autophagy axis. Biomolecules & Therapeutics. 2017. 1;25(5):511–8
ProductVision3ChAd 20 NEW.qxp_Layout 1 15/12/2020 12:18 Page 1
5 Lim J, Lim CJ, Kim S, Nam G, Chang M, Park K et al. Antiageing & antioxidant effects of topical autophagy activator: A randomised, placebo- controlled, double-blinded study. J. Cosmet. Dermatol. 2019. 18(1):197–203
6 Franceschi C, Bonafè M, Valensin S, Olivieri F, De Luca M, Ottaviani E, et al. Inflamm-aging: An
evolutionary perspective on immunosenescence. Annal. N. Y. Acad. Sci. 2006 Jan 25;908(1):244–54
7 Aeassa H, Eltoky MA, Fayyaz HE, Khalifa MKA, Shawky S, Helal NA et al. Current topical strategies for skin aging & inflammaing treatment: Science versus fiction. J. Cosmet. Sci. 2020. 12;71:321–50
8 Lee HM, Shin DM, Yuk JM, Shi G, Choi DK, Lee SH et al. Autophagy negatively regulates keratinocyte inflammatory responses via scaffolding protein p62/SQSTM1. JI. 2011. 15;186(2):1248–58
9 Li XM, Jung KE, Yim SH, Hong DK, Kim CD, Hong JY et al. Autophagy suppresses toll-like receptor 3-mediated inflammatory reaction in human epidermal keratinocytes. BioMed Research International. 2020. 5;2020:1–8.
10 Kim HR, Kang SY, Kim HO, Park CW, Chung BY. Role of aryl hydrocarbon receptor activation & autophagy in psoriasis-related inflammation. IJMS. 2020. 22;21(6):2195.
11 Hailfinger S, Schulze-Osthoff K. Impaired autophagy in psoriasis & atopic dermatitis: A new therapeutic target? J. Invest. Dermatol. 2021. 141(12):2775–7
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15 Hu L, Mauro TM, Dang E, Man G, Zhang J, Lee D et al. Epidermal dysfunction leads to an age-associated increase in levels of serum inflammatory cytokines. J. Invest. Dermatol. 2017. 137(6):1277–85
16 Ye L, Mauro TM, Dang E, Wang G, Hu LZ, Yu C et al. Topical applications of an emollient reduce circulating pro-inflammatory cytokine levels in chronically aged humans: A pilot clinical study. J. Eur. Acad. Dermatol. Venereol. 2019. 33(11):2197–201
17 Akinduro O, Sully K, Patel A, Robinson DJ, Chikh A, McPhail G et al. Constitutive autophagy & nucleophagy during epidermal differentiation. J. Invest. Dermatol. 2016. 136(7):1460–70
18 Shin KO, Lim CJ Park HY, Kim S, Kim BY, Lee YR et al. Activation of SIRT1 enhances epidermal permeability barrier formation through ceramide synthases 2- & 3-dependent mechanisms. J. Invest. Dermatol. 2020. 140(7):1435–8.
19 Misery L, Weisshaar E, Brenaut E, Evers AWM, Huet F, Ständer S et al. Pathophysiology& management of sensitive skin: Position paper from the special interest group on sensitive skin of the International Forum for the Study of Itch (IFSI). J. Eur. Acad. Dermatol. Venereol. 2020. 34(2):222–9.
20 Wu Y. Compromised skin barrier & sensitive skin in diverse populations. J. Drugs Dermatol. 2021. 20(4):6.
21 Szepietowski J, Matusiak, Szepietowska M, Krajewski P, Bialynicki-Birula R. Face mask- induced itch: A self-questionnaire study of 2,315 responders during the COVID-19 pandemic. Acta. Derm. Venereol. 2020. 100(10):adv00152.
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www.personalcaremagazine.com February 2022 PERSONAL CARE
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