ANTI-AGEING
Compared to initial value: ***p<0.001 ****p<0.0001
0.31
0.30 0.29 0.28 0.27 0.26 0.25 0.24 0.23 0.22
Microalgae extract (lyophilised) ■ Placebo ■ -6% ***
-12% ****
Compared to initial value: ***p<0.001 ****p<0.0001
0 28 Days
Figure 3: Skin firmness improvement with application of a gel containing 2% active (microalgae extract) on the face of volunteers
These two amino acids may have contributed to
the increase collagen synthesis observed in human primary fibroblasts. The presence of polyphenols in the extract certainly contributed to a decrease in collagen and microfibrils degradation by reducing oxidative stress.12
It has been shown that
polyphenols in Nannochloropsis species have the ability to protect dermal fibroblast from oxidative damage.13
Finally, the presence of carbohydrates
in the extract can target downstream inflammation reducing oxidative damage.4 In conclusion, we have developed a novel
microalga extract for cosmetic application, in particular to target skin ageing, such as loss of skin elasticity and firmness. The extract was developed through a sustainable approach. When used at clinical dosage in finished products to target skin ageing, the extract can improve skin tonicity and bring a lifting effect.
56
70 65 60 55 50
37
Microalgae extract (lyophilised) ■ Placebo ■ +10%
+5% ***
****
0
28 Days
Figure 4: Skin elasticity improvement from application of a gel containing 2% of the active (microalgae extract) on the face of volunteers
L. An Overview of potential oleaginous microorganisms and their role in biodiesel & omega-3 fatty acid-based industries. Microorganisms 8(3):434, 2020
3. Aslam A, Bahadar A, Liaquat R, Saleem M, Waqas A, Zwawi M. Algae as an attractive source for cosmetics to counter environmental stress. Sci. Total Environ. 772: 144905, 2021
4. Kim J.H, Lee J.E, Kim K.H, Kang N.J. Beneficial effects of marine algae-derived carbohydrates for skin health. Mar. Drugs 16(11):459, 2018
5. Tamaki S, Mochida K, Suzuki K. Diverse biosynthetic pathways and protective functions against environmental stress of antioxidants in microalgae. Plants (Basel) 10(6):1250, 2021
PC
References 1. Saide A, Martínez K.A, Ianora A, Lauritano C. Unlocking the health potential of microalgae as sustainable sources of bioactive compounds. Int. J. Mol. Sci. 22(9):4383, 2021
2. Patel A, Karageorgou D, Rova E., Katapodis P, Rova U., Christakopoulos P, Matsakas
Compared to initial value: *p<0.05
2.8 2.6 2.4 2.2 2.0 1.8 1.6 1.4 1.2 1.0
6. Karlson B, Potter D, Kuylenstiernai M, Andersen R.A. Ultrastructure, pigment composition & 18S rRNA gene sequence for Nannochloropsis granulata sp. nov. (Monodopsidaceae, Eustigmatophyceae), a marine ultraplankter isolated from the Skagerrak, northeast Atlantic Ocean. Phycologia 35 (3): 253-260, 1996
7. Vieira I.C, Toledo P.M, Silva J.M, Higuchi H. Deforestation & threats to the biodiversity of Amazonia. Braz. J. Biol. 68(4 Suppl):949-56, 2008
8. Meng C, Wang P, Hao Z, Gao Z, Li Q, Gao H., Liu Y, Li Q, Wang Q, Feng F. Ecological & health
Microalgae extract (lyophilized) ■ Placebo ■ +65%
+30% * *
Compared to initial value: *p<0.05
1.9 1.7 1.5 1.3 1.1
0 28 Days
Figure 5: Skin tonicity improvement with application of a gel containing 2% of the active (microalgae extract) on the face of volunteers
www.personalcaremagazine.com 56
0.9 0.7 0.5
risk assessment of heavy metals in soil & Chinese herbal medicines. Environ Geochem Health 1:1-12, 2021
9. Behera B, Venkata Supraja K, Paramasivan B. Integrated microalgal biorefinery for the production & application of biostimulants in circular bioeconomy. Bioresour Technol 339:125588, 2021
10. Huang P.W, Wang L.R, Geng S.S, Ye C, Sun X.M, Huang H. Strategies for enhancing terpenoids accumulation in microalgae. Appl Microbiol Biotechnol 105(12):4919-4930, 2021
11. Li X, Wang X, Duan C, Yi S, Gao Z, Xiao C, Agathos SN, Wang G, Li J. Biotechnological production of astaxanthin from the microalga Haematococcus pluvialis. Biotechnol Adv 43:107602, 2020
12. Rani A, Saini KC, Bast F, Mehariya S, Bhatia SK, Lavecchia R, Zuorro A. Microorganisms: A potential source of bioactive molecules for antioxidant applications. Molecules 26(4):1142, 2021
13. Kim HM, Jung JH, Kim JY, Heo J, Cho DH, Kim HS, An S, An IS, Bae S. The protective effect of violaxanthin from Nannochloropsis oceanica against ultraviolet B-induced damage in normal human dermal fibroblasts. Photochem. Photobiol. 95(2):595-604, 2019
Microalgae extract (lyophilised) ■ Placebo ■ +53%
+33% * *
56
0
28 Days
Figure 6: Lifting effect improvement with application of a gel containing 2% of the active (microalgae extract) on the face of volunteers
February 2022 PERSONAL CARE
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Clinical Grading ± s.d.
Skin suction (mm) ± s.d.
Clinical Grading ± s.d.
Skin elasticity % ± s.d.
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