Microscopy & Microtechniques 55
Unified license and knowledge tool simplifies software access
Next-generation cryo-TEM accelerates molecular structure research
Thermo Fisher Scientific has unveiled its most advanced cryo-transmission electron microscope (cryo-TEM) - the Krios™ 5 Cryo-TEM - designed to meet the growing demands of researchers investigating the structure and function of complex biological systems.
Building on the success of its predecessor, the Krios 5 delivers a step-change in cryo-EM performance, combining enhanced optics, streamlined workflows, and smart automation to significantly increase throughput and data quality. Capable of revealing the finest molecular details, the system supports both single particle analysis (SPA) and cryo-electron tomography (cryo-ET) applications.
Binary Vision has introduced a significant upgrade to its BV Nexus platform, marking a step forward in how laboratory instrument manufacturers manage their software lifecycle. Announced at this year’s Microscopy and Microanalysis conference, the update delivers a streamlined, centralised system for license management - allowing users to view all active licenses, subscriptions, and expiry dates in one intuitive dashboard. It also enables instant online purchases and renewals, removing friction from software access and helping labs stay up to date with the latest tools.
Integrated within BV Nexus, this new feature also provides direct access to product documentation and training materials. Users can manage licenses and access expert support through a single interface on their lab PC, tablet, or mobile device. By combining operational control with embedded knowledge, the system improves both usability and productivity.
Oxford Instruments recently previewed the feature at the Microscopy and Microanalysis conference within its OI View platform, which is powered by BV Nexus. OI View delivers real-time insights into instrument performance, and the addition of unified license and knowledge management further enhances the platform’s value to customers.
“Managing licenses and users should not be separate processes,” said Paul Norris, CEO of Binary Vision. “This feature closes that gap - keeping organisations current with their software and giving their teams the information they need to succeed.”
Dr Giulia Degli Alessandri, from the Electron Microscopy Suite at the Open University, commented: “It helps with the everyday running of a multi-user facility. Everything is within this platform, so it’s accessible for all staff members together.”
This latest development reflects Binary Vision’s commitment to practical, user-led digital transformation. By embedding license control and product expertise into one environment, BV Nexus enables suppliers to streamline their software delivery while offering customers a more personalised, connected experience. It supports more agile, responsive, and informed laboratory operations- helping research teams get the most from their digital tools.
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The Krios 5 introduces a suite of improvements aimed at accelerating structure determination. AI-guided setup simplifies operation, while upgraded data acquisition tools increase image quality and consistency. With up to 25% greater throughput compared to earlier models, the Krios 5 allows researchers to extract more information in less time - bringing high-resolution 3D reconstructions of proteins and macromolecular complexes within closer reach.
For users focused on cryo-ET, a new vacuum capsule transfer system helps protect sensitive lamellae during sample handling, minimising ice contamination and preserving integrity throughout the imaging workflow.
High-fidelity visualisation of protein interactions, viral architecture, and cellular machinery is key to advancing drug development and therapeutic innovation. The Krios 5 supports this effort by making routine what was once considered cutting-edge - allowing researchers to push further into complex biological questions with confidence.
Trisha Rice, VP and General Manager of Life Sciences for Materials and Structural Analysis at Thermo Fisher Scientific, commented: “The Krios 5 Cryo-TEM delivers the automation, reliability, and performance that modern labs need to translate structural insights into scientific and therapeutic breakthroughs. It’s the result of close collaboration with the cryo-EM community and our ongoing mission to empower researchers with the tools to fight disease at the molecular level.”
The Krios 5 is equipped with an energy-efficient standby mode that reduces power usage without delaying experiments. It also carries the My Green Lab ACT ecolabel certification, aligning with lab sustainability goals.
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ilmt.co/PL/pxzB 65032pr@reply-direct.com New spinning disk confocal microscopes for live-cell imaging
Two spinning disk confocal microscopes - IXplore IX85 SpinXL and SpinSR - have been introduced by Evident to support advanced live-cell imaging and super-resolution studies. Both systems are built on the IXplore IX85 automated inverted platform and offer improved acquisition speed, resolution, and sample protection.
The SpinXL, based on CrestOptics X-Light technology, delivers a 26.5 mm field number for rapid screening of large areas. Dual-camera support and near-infrared compatibility enable deeper imaging with minimal phototoxicity, making it well-suited for dynamic, high- throughput experiments.
The SpinSR, incorporating Yokogawa CSU-W1 technology and the TruSight SR algorithm, achieves lateral resolution down to 120 nm. It enables detailed time-lapse imaging of subcellular structures, with real-time control and intensity-preserving processing suitable for quantitative workflows. A 3D processing algorithm extends performance into organoid and deep-tissue samples.
Both systems are compatible with the LUPLAPO25XS silicone immersion objective, enabling improved 3D volumetric reconstruction and imaging at depth.
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Ultra-high-speed camera reveals invisible phenomena
Shimadzu Europa has introduced the HyperVision HPV-X3, a next-generation ultra-high-speed video camera capable of recording at 20 million frames per second. Designed for capturing ultra-fast microscopic events, the HPV-X3 delivers three times the resolution of its predecessor while maintaining image quality at top speeds.
Equipped with the newly developed FTCMOS3 CMOS image sensor, created in collaboration with Tohoku University, the HPV-X3 sets a new benchmark in high-speed imaging. The camera is ideal for use in materials science, aerospace, and increasingly in medical and industrial research, where visualising high-speed processes is critical.
The HPV-X3 doubles the speed of the HPV-X2 and adds support for frame-by-frame external signal synchronisation, a first for Shimadzu. This enables precise timing control between image capture and specimen illumination - essential for applications such as digital image correlation (DIC) and the study of dynamic deformation in materials testing.
Shimadzu’s leadership in high-speed imaging dates back to 2005. In 2022, Shimadzu and Tohoku University were jointly awarded the Inoue Harushige Prize for the development and commercialisation of the FTCMOS sensor series - recognised for excellence in university - industry collaboration.
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ilmt.co/PL/XwQQ 65117pr@reply-direct.com
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