Microscopy & Microtechniques 51 New Software Suite Enhances Raman Microscopy Capabilities
WITec GmbH, a specialist in Raman microscopy, has launched Suite SIX, the latest software for controlling Raman and correlative measurements, as well as data acquisition and post-processing. The software has been designed to further enhance the highly confi gurable alpha300 microscope series by providing multiple user profi les, support for regulatory compliance, and advanced sample navigation features.
Suite SIX’s multi-user management feature empowers the site administrator to assign instrument functionalities and data access rights to each system login, assisting labs in their efforts to comply with good practice (GxP) guidelines such as the US Food and Drug Administration’s 21 CFR Part 11, which is essential for pharmaceutical research and development. Moreover, the software enables users to create a repository of unique hardware confi gurations, which simplifi es the process of conducting recurring experiments.
As described by Dr Wolfram Ibach, Director of Software at WITec: “Suite SIX lets industrial facilities and research groups virtually customise the microscope for each individual user, with the appropriate feature set and data handling protocols. This accelerates the experimental workfl ow while ensuring compatibility with their training and standard operating procedures.”
TrueOrigin, the portable coordinate system integrated within Suite SIX, enables quick location of measurement areas relative to markers on the sample holder or features on the sample. This accelerates the correlation of data collected through multiple techniques from the same position, even if the sample is transferred between instruments. It also allows users to import sample images captured with an external camera to navigate to a specifi c area of interest and facilitate project documentation.
“Anyone performing correlative measurements on multiple instruments knows how time-consuming it can be to fi nd a particular area or feature after re-mounting a sample,” said Dr Thomas Dieing, WITec Product Manager. “Our portable coordinate system automates that process so researchers can go right to the next measurement, even on another microscope.”
WITec Suite SIX is available now. More information online:
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Digital Microscope Simplifi es Cell Culture Checks
Mateo TL, a new digital transmitted light inverted microscope for routine cell culture, has been launched by Leica Microsystems. With Mateo TL, lab members can easily and comfortably check and document cell growth. By consistently measuring confl uency, they can be confi dent in the readiness of their samples for downstream experiments.
“Good cell culture sample preparation is an important starting point for every successful experiment, and now it has become even easier and more reliable with Mateo TL,” said James O’Brien, Vice President of Life Sciences and Applied Microscopy at Leica Microsystems.
“During the sample preparation process, subjective judgements are often used for sample readiness assessments, which can compromise the quality and the outcome of experiments, said Jennifer Kulhei, Product Manager, Life Science and Research Microscopy at Leica Microsystems.
With Mateo TL, labs can establish a reliable criterion for evaluating confl uency, improving experiment reproducibility. The confl uency algorithm measures the percentage of cell coverage in the image, enabling consistent measurements across multiple users. Additionally, users can work in a sterile environment to minimise contamination risk by placing Mateo TL directly under the fl ow hood, ensuring the integrity of their experimental outcomes.
Mateo TL is a user-friendly microscope that is easy to set up and use, even for non-experts. It is designed to support cell culture checks for a
range of users, from principal investigators and postdoctoral researchers to PhD and master’s students, as well as lab technicians, all of whom may have varying levels of microscopy expertise. The microscope can be set up in less than a minute, providing a ready-to-use system that team members can start working on immediately. Once set up, cell culture checks are made easy for the whole team with Mateo TL’s user-friendly software interface, enabling simple live viewing and image acquisition.
In addition to its user-friendly design, Mateo TL streamlines cell culture checks by improving effi ciency and convenience. With its convenient fi le sharing capabilities, smart light and camera settings, and enhanced ergonomics, Mateo TL empowers teams to spend less time on routine cell culture checks and more time on their experiments.
More information online:
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Glass Bottom µ-Plates Enable High Throughput and Super-Resolution Microscopy
Microscopists now have high-throughput possibilities for super-resolution and TIRF thanks to Ibidi’s new glass bottom µ-plates. When using the µ-Plate 96 Well or 384 Well Black Glass Bottom, the samples are observed through a thin #1.5H D 263 M Schott glass coverslip with a thickness of 170 µm +/- 5 µm. Due to its superior optical quality, the µ-Plates are not only suitable for standard microscopy applications, but also ideal for total internal refl ection fl uorescence (TIRF), super-resolution microscopy (STED, SIM, (F)PALM, (d)STORM), and fl uorescence correlation spectroscopy (FCS).
When using the µ-Plate 96 Well or 384 Well Black Glass Bottom, the samples are observed through a thin #1.5H D 263 M Schott glass coverslip with a thickness of 170 µm +/- 5 µm. Due to its superior optical quality, the µ-Plates are not only suitable for standard microscopy applications, but also ideal for total internal refl ection fl uorescence (TIRF), super-resolution microscopy (STED, SIM, (F)PALM, (d)STORM), and fl uorescence correlation spectroscopy (FCS).
The µ-Plates have square wells and feature optimal fl atness properties, which are crucial for high-resolution microscopy in screening applications. The glass coverslip provides high accuracy and facilitates imaging from well-to-well across the entire plate. Additionally, the black walls ensure low well-to-well crosstalk in fl uorescence microscopy.
The µ-Plates are ideal for the cultivation, high throughput screening (HTS), and high-resolution microscopy of cells. They meet the requirements of the ANSI/SLAS standard, and are therefore compatible with a variety of imaging systems, pipetting robots, and plate readers. Researchers who would like to test the new µ-Plate 96 Well or 384 Well Black Glass Bottom with their own experiments can get free samples.
More information online:
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