50 Advanced Solutions for Particle Size and Shape Analysis
HORIBA offers a broad portfolio of solutions for measuring the size and shape of particles in a variety of products and manufacturing processes. A top of the range optical system combined with an unmatched smart and compact design make HORIBA’s instruments the most reliable and precise particle characterisation analyser range available. They provide the full power of laser diffraction within simple-to-use and easy-to-maintain solutions for analysis of a wide range of materials.
Partica LA-350 is a powerful tool in Quality Control with the smallest footprint, yet delivering the same accuracy as bulky and more expensive instruments. Its compact size means the LA-350 can be transported and used virtually anywhere.
For more in-depth particle analysis, Partica LA-960 provides a comprehensive solution with a wide measuring range (10 nm – 5,000 μm), offering a variety of accessories for analysing powders, paste and viscous solutions without increasing the instrument footprint. HORIBA’s brand-new Imaging Unit Accessory allows the direct observation of suspended particles, measuring their shape and providing useful data for their characterisation. This imaging tool is essential for the optimisation of advanced product and industrial processes design.
HORIBA’s solutions include nanoparticle analysis with the nanoPartica SZ-100, enabling the measurement of the smallest sizes down to 0.3 nm. A simple setup and user-friendly interface facilitate measurement of size and stability of formulation dispersion (zeta potential measurement) within seconds. The SZ-100 is an essential tool in any formulation and biomedical laboratory, indispensable for the analysis of proteins, nanoparticles and advanced materials such as quantum dots and carbon nanotubes.
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ilmt.co/PL/Z43B and
ilmt.co/PL/QqDx 59628pr@reply-direct.com Using Fluorescence Imaging for Improved Outcomes in Skin Cancer Surgery
University of Rochester Professor Michael Giacomelli recently received NIH funding for his project, ‘Fluorescence microscopy for evaluation of Mohs surgical margins’. His research objective is to enable real-time evaluation of pathology in skin tissue with an order of magnitude reduction in processing time as compared to frozen sections.
The most common forms of cancer worldwide are basal cell carcinoma and squamous cell carcinoma. Mohs surgery is a widely used technique for the treatment of nonmelanoma skin cancer that obtains extremely low recurrence rates by imaging tissue as it is removed from the body to ensure complete resection. Mohs Micrographic Surgery, also called Mohs Surgery, is a specialised technique to remove non-melanoma skin cancers.
Nonmelanoma skin cancer (NMSC) is primarily diagnosed by histologic analysis of skin biopsy specimens in kerosene sections, which takes days to weeks before a formal diagnosis is made. Two-photon fluorescence microscopy (TPFM) has the potential for point-of-care diagnosis of NMSC and other dermatologic conditions, which could allow diagnosis and treatment at the same site.
Professor Giacomelli developed a way to image multiple depth slices without frozen section processing‚ by implementing two-photon imaging, widely used in the neurosciences to noninvasively image slices at different depths in living brains. The lab team’s research has adapted these fluorescence imaging technologies with rapid tissue labelling and image processing technologies. This enables real-time assessment of pathology in skin tissue. processing time compared to frozen sections has been reduced by an order of magnitude. The data collection time is further reduced using the lower- noised silicon photomultiplier detectors developed by Giacomelli’s group.
2-photon fluorescence microscopy can provide rapid point-of-care diagnosis of non-melanoma skin cancer through real-time imaging of fresh tissue biopsies.
Toptica Photonics’ femtosecond laser system - FemtoFiber ultra 920 - chosen for the next iteration of the Giacomelli lab’s microscope is a possible solution for applications in non-linear microscopy like two-photon excitation of fluorescent proteins and SHG based contrast mechanisms. With an emission wavelength of 920 nm, it provides the highest peak power for imaging with green and yellow fluorescent protein markers (GFP, YFP) commonly used in pathology, neurosciences and other laser-related biophotonic disciplines. Researchers appreciate the usability of the system since it is both, maintenance free and very compact.
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ilmt.co/PL/WMKQ All-in-One Cell Imaging System
Zeiss has launched its latest all-in-one cell imaging system, the Zeiss Axiovert 5 digital, which employs artificial intelligence (AI) and automatic functions to streamline daily tasks in the cell lab. This system enhances processes, from basic research to scientific routine, by enabling more efficient and reproducible phase contrast and multichannel fluorescence imaging. Additionally, the system is designed with an intuitive operating concept, allowing even inexperienced users to produce excellent images with ease. The settings and adjustments are carried out automatically, further simplifying the imaging process.
Laboratory technicians and researchers can employ brightfield, phase, and fluorescence contrast techniques to examine cell or tissue cultures. With the press of a button, the system takes control and automatically modifies the exposure time, captures the image, switches the channel, and restarts the process. The images are saved automatically, along with all the relevant metadata and scaling information of the microscope.
The Zeiss Axiovert 5 digital system utilises artificial intelligence to optimise and streamline workflows. By using the readily available AI modules, cell counting and cell confluency can be automatically determined with a single click of a button. This allows users to quickly measure and display the percentage of cell coverage or number of cells in their Petri dish.
The ergonomic layout of the Zeiss Axiovert 5 digital is tailored to support appropriate system operation, making it an ideal fit for multi-user environments. Users can easily trigger single snaps, multi- channel image acquisitions, or video recordings with just the press of a button, requiring minimal training or prior knowledge.
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ilmt.co/PL/WMOv 59803pr@reply-direct.com New Cryo-TEM to Help Accelerate Drug Discovery Research
The Thermo Scientific Glacios 2 Cryo-Transmission Electron Microscope (Cryo-TEM) is a powerful microscope with new automation and high-resolution imaging capabilities designed to help cryo-electron microscopy (cryo-EM) researchers of varying experience levels accelerate structure-based drug discovery. This advanced, fast and cost-efficient method for drug design may enable customers to accelerate the pace of research for debilitating disorders like Alzheimer’s, Parkinson’s, and Huntington’s diseases, as well as research for cancer and gene mutations.
The Glacios 2 Cryo-TEM includes automation features designed to extend accessibility to a range of cryo-EM techniques, including single particle analysis, cryo-electron tomography (cryo-ET) and microcrystal electron diffraction (MicroED). Additional highlights include fringe-free imaging for the acquisition of more usable images per foil hole, increased throughput compared to other commercially available optical alignment solutions and a new enclosure and hardware improvements built to offer enhanced performance compared to prior models.
This next generation solution can generate <2 angstrom 3D reconstructions and produce images faster than its predecessor. These capabilities can help users of all experience levels increase productivity at a time when rapid innovation and emerging cryo-EM applications are placing increasing demands on expert microscopists.
“Using the Glacios 2 Cryo-TEM, we developed a workflow that enables us to determine structures of small, asymmetric complexes at high resolution and with high throughput,” said Basil Greber, principal investigator for The Greber Laboratory at the Institute of Cancer Research and beta user of the new Glacios 2 Cryo-TEM. “Uncovering such structures provides us with detailed insight into inhibitor binding and suggests a mechanism for target selectivity in cancer therapeutics that we are currently testing.”
The new system also includes Thermo Scientific Smart EPU Software, which contains components needed for automated data acquisition, including microscope alignment and readiness assistance, plus an open API to allow for the development of solutions tailored to a user’s needs.
For pharma and biotech companies, the Glacios 2 Cryo-TEM offers high-throughput screening and imaging to enable the routine structure generation of druggable targets, including key targets of <120 kDA in size. For labs with growing demand for cryo-EM, the Glacios 2 solution helps increase accessibility to near atomic resolution structures, while improving ease-of-use and reproducibility across a variety of workflows.
More information online:
ilmt.co/PL/Y0wp 58936pr@reply-direct.com
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INTERNATIONAL LABMATE - APRIL 2023
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