43 Drug Discovery & Pharmaceuticals New Pooled Donor Suspension Hepatocytes Enables Reproducibility
Lonza announces the launch of DonorPlex™ Hepatocytes, a new line of high-quality cryopreserved pooled donor suspension hepatocytes, which are the first of their kind to be produced using Lonza’s novel patented manufacturing process. Researchers within DMPK and ADME laboratories can now benefit from this reliable and robust product offering for studying the hepatic metabolism of drugs.
Understanding hepatic drug metabolism is necessary to meet the strict safety-testing requirements for market approval of new products. Researchers typically need to use primary cryopreserved hepatocytes from a large number of donors to obtain a statistically significant result. However, pooled donor hepatocytes currently available on the market commonly suffer from increased lot-to-lot variability, while not being able to meet more specialised application needs.
Lonza’s patented manufacturing process ensures that the DonorPlex™ Hepatocytes exhibit improved phenotype reproducibility. Furthermore, a proprietary algorithm that predicts yield, viability and functional phenotype prior to manufacture ensures individual customer specifications are met.
“Drug discovery scientists require access to high-quality hepatocytes that can deliver consistent and dependable results to expedite new product approval,” said Dr Maureen Bunger, Product Manager for ADME-Tox Solutions at Lonza. “Lonza’s DonorPlex™ Hepatocytes have been designed to do just that. Our patented pooling procedure, in combination with our predictive algorithm, means we can provide our customers with a variety of hepatocyte configurations and sizes that either represent the average population or meet specific metabolism testing and cytochrome P450 (CYP) activity needs.”
The DonorPlex™ Hepatocytes offer a large, comprehensive inventory of cryopreserved single donor suspension hepatocytes, which include a range of 10-, 20- and 50-donor gender-specific and mixed- gender lots.
48395pr@reply-direct.com Fluorescent Biosensors as Tools for Drug Therapeutics
Researchers in the School of Pharmacy at the University of Nottingham have been using Dolomite Microfluidic’s chips to enhance their work on drug encapsulation and therapeutic delivery. Dr Veeren Chauhan, Research Fellow in the Advanced Materials and Healthcare Technologies (AMHT) group, working with Dr Jonathan Aylott and Dr Amjad Selo, explained: “We have been using Dolomite chips since the end of 2017 and, since then, have continuously manufactured an array of uniformly-sized PLGA particles. We can fine-tune the system set-up, depending on the downstream requirements, to provide a consistent particle shape and size, as well as control drug release parameters. These attributes are key to ensuring the correct dose of drug is maintained, achieving maximum therapeutic benefit without unwanted side-effects.”
Amjad added: “We are optimising conditions to produce fluorescent PLGA to act as a biosensor, storing and releasing biological medicines dependant on environmental changes. These novel particles can detect and monitor specific analytes in the body and, due to their fluorescent properties, can be used to assess biochemical interactions and processes within cells.”
“Using Dolomite’s microfluidic chips has significantly enhanced the innovative work we are able to perform. The beauty of using such small chips means we can produce vast quantities of particles, while occupying very little lab space, and can ensure a continuous flow of homogeneous, reproducible particle batches,” Veeren concluded.
48792pr@reply-direct.com ADVERTORIAL Pipetting Robot Simplifi es Liquid Handling Automation
Integra understands that today’s scientists want to do more than just straightforward pipetting tasks in microplates. Taking a fresh approach to pipetting innovation, the company asked laboratories about the specifi c challenges they face, and how these could be overcome by enhanced liquid handling products. The feedback was unanimous. Researchers want a pipetting robot that is easy to use, even for novices. The system must also accommodate various types of labware, providing the fl exibility scientists need to take the strain out of their routine pipetting tasks.
The Integra team members put their heads together and came up with the ASSIST PLUS pipetting robot, offering streamlined, cost-effective pipetting workfl ows to suit most budgets. ASSIST PLUS can be programmed either directly on the pipette or remotely from a PC, and includes the latest VIALAB software for straightforward set-up of more complex workfl ows.
It has three deck positions to accommodate reagents, tubes and samples, and is compatible with numerous labware types and any of Integra’s electronic multichannel pipettes, including the VOYAGER adjustable tip spacing pipette. This unique feature offers built-in longevity, simply swap in a different Integra pipette to access new applications, and will provide reliable, reproducible and error-free pipetting for many years to come.
More information online:
ilmt.co/PL/43Km 48521pr@reply-direct.com
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