8 New Fully Automated Preparation Module for LC-MS Released
Shimadzu has released the CLAM-2030 fully automated preparation module for LC-MS. This module automates everything from the preparation of urine, blood and other biological samples to measurement via liquid chromatography mass spectrometry (LC-MS). In only 3 to 8 minutes, the CLAM-2030 preparation module completes the blood samples preparatory process including the addition of reagents, mixing of the solution and the addition of a deproteinisation liquid, all of which conventionally takes 15 to 20 minutes. Furthermore, if the samples and reagents are placed and positioned in special containers for automatic conveyance to the LC-MS by an autosampler, the module can perform all of the processes automatically, on weekends and overnight.
In response to the needs of clinical research sites, the CLAM-2030 provides stable data acquisition, lower running costs and improved work efficiency. The module can be connected to four models of triple quadrupole liquid chromatograph mass spectrometers, the LCMS-8040, LCMS- 8045, LCMS-8050 and LCMS-8060. Work efficiency is further improved by using it in combination with a commercial analysis kit.
To enable automatic measurement of up to 60 samples, the special preparation containers simply have to be placed in the module. Approximately 20 samples can be processed per hour. If the forensic toxicological database and the rapid toxicology screening system (options available from Shimadzu) are used, the library can be searched automatically and reports can be generated after preparation.
A special structure (using septa) prevents vaporisation of internal standard substances, thereby suppressing concentration fluctuations and leading to a more stable measurement process. Additionally, multiple management functions including ID management of samples via a barcode reader
(option), management of expiration dates and remaining quantities of reagents, and maintenance log records maintain the module in an optimal state.
After samples and reagents are positioned, preparation can be started with simple operations, alleviating mistakes due to manual procedures. The waste box for preparation containers and the waste liquid tank are equipped with full sensors, which help reduce the risk of infections during sample preparation. More information online:
ilmt.co/PL/9ZZy
48572pr@reply-direct.com
New Fluorescence Spectrometers Accurately Analyse a Broad Range of Sample Types
PerkinElmer, Inc have announced the launch of its FL 6500™ Pulse Xenon and FL 8500™ Continuous Wave Fluorescence Spectrometers. The instruments enable industrial companies, universities, government, contract and pharmaceutical laboratories to analyse a diverse range of sample types, to meet growing research or evolving compliance requirements. When used together, these create a comprehensive fluorescence spectrometer solution for research and commercial laboratories to handle a variety of application challenges.
The FL 8500 fluorescence spectrometer uses a high performance Xenon continuous wave excitation source with PerkinElmer optics for high sensitivity measurements, at scan speeds up to 60,000 nanometers. It can be configured for a range of applications, including material characterisation; industrial tracing and manufacturing R&D; agricultural and environmental analysis; along with analysis of LEDs, solar cells and organic electroluminescent materials.
The FL 6500 fluorescence spectrometer, which uses PerkinElmer optics and a Xenon pulse excitation source with variable power settings, is designed for testing samples that are susceptible to photo bleaching. Applications include: cell biology, molecular biology, immunology, enzymology and protein analysis, as well as thin coatings. Both instruments share the new Spectrum™ FL software that mirrors laboratory workflows for simple, streamlined method development and comprehensive data analysis in minutes. Optional interchangeable, plug-and-play accessories are auto-recognised by the software to further minimise downtime.
The intuitive software is also available in Enhanced Security (ES) to maintain Title 21 CFR Part 11 compliance and adhere to stringent data integrity requirements, preventing laboratories from incurring costly fines.
new FL 6500 and FL 8500 systems include: improved signal to noise performance measurement for lower level analysis; better resolution to increase the number of spectral peaks that can be resolved; enhanced smart accessory interface for easy installation; fully-integrated thermal accessories to allow direct control of cuvettes for enhanced capability with molecular biology applications; PerkinElmer’s Radian™ proprietary instrument remote monitoring system.
48262pr@reply-direct.com Updates to Spectrus® and Percepta® ACD/Labs’ v2018.1 software release includes the following updates:
Usability Improvements to Method Development Solutions - by consolidating functionality from across our various chromatography applications into two comprehensive method development and optimisation solutions: the improved ACD/AutoChrom, and the new ACD/Method Selection Suite. Particularly, Method Selection Suite combines physicochemical property predictions with method optimisation tools to define better starting conditions, estimate retention times, and optimise key separation parameters, all according to quality by design (QbD) principles.
NMR and MS Dereplication - two new features to streamline identification of ‘known unknowns’ in both NMR and MS analysis. The Known Structure Identification NMR workflow, available as an add-on to both ACD/NMR Workbook Suite and ACD/Spectrus Processor, quickly determines whether experimental 13C spectra match predicted signals of known compounds. Similarly, improvements to the Intelligent Component Recognition workflow in ACD/MS Workbook Suite enable efficient identification of LC and GC known unknowns through batch spectral searching. Additional key NMR and MS updates include improved peak picking and multiplet assignment accuracy for 13C NMR spectra of fluorinated compounds, and upgraded MS Tree control to better visualise multiple MS spectra together.
Analytical Knowledge Management in Pharmaceutical Development - v2018.1 includes multiple requested features for Luminata™ and MetaSense™. Luminata now includes automated calculation of impurity carryover across stages, and improved handling of process schema imported from third-party drawing packages - including reagents and reactants. MetaSense users can now identify a greater number of metabolites through the addition of user-defined reactions, expand the scope of projects by analysing data from multiple different species (human, mouse, rat, dog) together, and accelerate reporting by utilising customisable reporting templates.
Physicochemical and ADME/Tox Property Prediction - v2018.1 of the Percepta platform, which provides in silico predictions of physchem, ADME, and toxicity properties, includes significant improvements to our logP structure database (>1700 compounds added) to deliver more reliable and accurate logP estimates for novel compounds. Plus, this expansion also improves prediction tools that require logP - logD, oral bioavailability, blood-brain barrier penetration, and more.
More information online:
ilmt.co/PL/wEJK New Spectrometer Delivers Fast, Accurate Analysis
The Ocean MZ5 from Ocean Optics is a compact, fully integrated ATR-MIR spectrometer that measures liquid samples from 1818-909 cm-1 (5.5-11 µm). Ocean MZ5 comprises a sample interface, light source, detector and software, and provides a fast, convenient alternative to traditional FTIR spectroscopy for lab research. Applications range from chemical discrimination and food and flavourings authentication, to biofuels analysis and environmental testing.
Ocean MZ5 is a self-contained system that does not require any external equipment such as light sources or fibres. Ocean Mirror, the dedicated software platform that comes with the system, is designed for measuring absorbance and transmittance of liquids placed on the instrument’s crystal surface. A rotating cover protects the crystal when not in use.
Ocean Optics has extensive applications and solutions development experience across the UV, Visible and NIR wavelength ranges. With Ocean MZ5, the company has partnered with Pyreos Ltd to expand its capabilities into new mid-IR solutions. The unique combination of Pyreos’ pyroelectric line arrays and Ocean Optics’ applied spectral knowledge opens up new application challenges involving samples with distinct mid-IR absorption characteristics. This includes detection of food adulterants and contaminants, determination of oil grade and quality, and analysis of alcohol purity.
48264pr@reply-direct.com
47536pr@reply-direct.com Platforms Released
ACD has announced significant updates across its ACD/Spectrus and ACD/Percepta platforms. Version 2018.1 delivers greater functionality to all ACD/Labs products, including key tools for LC and GC method development specialists, mass spectrometrists, NMR spectroscopists, plus analytical and process chemists in pharmaceutical development.
INTERNATIONAL LABMATE - APRIL 2019
Page 1 |
Page 2 |
Page 3 |
Page 4 |
Page 5 |
Page 6 |
Page 7 |
Page 8 |
Page 9 |
Page 10 |
Page 11 |
Page 12 |
Page 13 |
Page 14 |
Page 15 |
Page 16 |
Page 17 |
Page 18 |
Page 19 |
Page 20 |
Page 21 |
Page 22 |
Page 23 |
Page 24 |
Page 25 |
Page 26 |
Page 27 |
Page 28 |
Page 29 |
Page 30 |
Page 31 |
Page 32 |
Page 33 |
Page 34 |
Page 35 |
Page 36 |
Page 37 |
Page 38 |
Page 39 |
Page 40 |
Page 41 |
Page 42 |
Page 43 |
Page 44 |
Page 45 |
Page 46 |
Page 47 |
Page 48 |
Page 49 |
Page 50 |
Page 51 |
Page 52 |
Page 53 |
Page 54 |
Page 55 |
Page 56 |
Page 57 |
Page 58 |
Page 59 |
Page 60 |
Page 61 |
Page 62 |
Page 63 |
Page 64 |
Page 65 |
Page 66 |
Page 67 |
Page 68 |
Page 69 |
Page 70 |
Page 71 |
Page 72
