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New Yellow Fever Virus Recombinant Protein for Diagnostic Testing Launched
Aalto Bio Reagents have announced the availability of its first-to-market recombinant Yellow Fever virus (YFV) protein (code CA 6325) for diagnostic test manufacturers, vaccine developers and researchers globally. This His-tagged, recombinant protein is expressed in HEK293 cells and is derived from strain 17D. YFV, a potentially fatal mosquito-borne flavivirus, is prevalent in tropical and subtropical locations in South America and Africa.
YFV is transmitted to humans mainly by sylvatic mosquito vectors of the genera Haemagogus and Sabethes, but has also been known to be spread by the sinister Aedes aegypti mosquito which is responsible for the current Zika virus epidemic. In humans, the majority of YFV infections are asymptomatic; however approximately 15% of infected patients enter what is known as the toxic phase and this can lead to severe complications such as jaundice, multi-organ failure and even death.
Laboratory diagnosis is generally accomplished by means of serological testing for the detection of antibodies during the postviremic phase of the disease (i.e. from the 5th day since the onset of symptoms). YFV is difficult to diagnose, especially in the early stages, as cross-reaction with other flavivirus infections is common. There are no validated IgM ELISA kits commercially available at present and in order for YFV infection to be confirmed by serologically techniques, a differential diagnosis with other flavivirus infections must be carried out.
Philip Noone, CEO of Aalto Bio Reagents, said “Brazil is currently experiencing its largest YFV outbreak in decades. There is an urgent need for a specific and sensitive serological YFV assay in countries such as Brazil, where co-circulation with other flaviviruses is high. Our industry has an unrelenting requirement for access to the most scientifically proven raw materials, a broader range of flexible controls and faster diagnostics. With our Zika, Chikungunya, Dengue Triplex and now our Yellow Fever solution we are truly building a comprehensive tropical product listing to meet this need. We envisage that our YFV protein will provide the critical element to further diagnostic companies’ research and development of IgG and potentially IgM assays. We will continue to focus on the expansion of our tropical disease products with even more additions in 2017-18 to enable our customers to bring superior, best-in-class diagnostic products to market faster, and aid in the development of life-saving vaccines.”
43595pr@reply-direct.com
New Measuring Instrument Provides Simultaneous Analysis of Foam Stability and Structure Under High Pressure
With its High Pressure Foam Analyzer – HPFA, Krüss GmbH is launching the world’s first measuring instrument for the simultaneous capture of foam height and foam structure under high pressure. The HPFA is intended primarily for the tertiary oil production sector, where foams boost the efficiency of flooding procedures using gases such as carbon dioxide or nitrogen. The foam improves flow control, so that the oil can be extracted efficiently from the rock. The foams used must remain stable for a long period under the high pressure of the reservoirs and also withstand strong deformations during flows through porous rock. So the structure of the foam lamellae and the decay dynamics at high pressure are extremely relevant for the efficiency of the process.
The HPFA is equipped with high-resolution cameras that capture the foam volume and a video image of the foam lamellae in parallel during and after foaming. With the aid of the ADVANCE software’s real-time image evaluation the instrument measures the foamability and foam decay as well as changes in the absolute bubble size and its statistical distribution. The measuring cell of the
HPFA operates at pressures up to 350 bar and temperatures up to 120°C. During the analysis sensors permanently transmit measured values for pressure and temperature to the software.
The repeatability of foam formation is ensured by a filter through which the gas flows into the liquid
under pressure. Variable filters with different pore sizes simulate the characteristic porosity of the respective rock and enable the modelling of foams with different bubble sizes.
When using the foam in the recovery process the aqueous foam in the reservoir often comes up against the foam inhibiting oil. This can trigger undesired foam decay. To date it has not been possible to test this effect under reservoir conditions. To make this possible, the HPFA comes equipped with a novel dosing unit that enables the dosing of any kind of liquid under pressure during the ongoing foam analysis.
43360pr@reply-direct.com
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