20 instrument is a big success, especially for urine analysis.”
Dr Böttcher’s laboratory uses two drug libraries for their toxicology work; one developed by Bruker and one by an external scientific institute: the Maurer/Wissenbach/Weber (MWW) Library (Wiley-VCH, Weinheim, Germany, 2014, TT-M2). The laboratory uses Bruker’s library, which contains approximately 1000 parent substances, for scheduled purposes: there is a narrow detection time window where the substance must be found if it is present. This leads to increased sensitivity as the software is directed to the specific substance. The MWW library contains 1500 substances as well as 3000 metabolites (including glucuronides) and unlike the Bruker library, it is not indexed on retention time. This means that sensitivity is lower, but the library is extremely comprehensive and contains the necessary metabolites in addition.
Toxicology in the Future
Due to the rapidly changing industry in which laboratories such as MVZ Labor Dessau conduct their work, new methods must constantly be developed to keep pace with the drugs market. To facilitate this, instrumentation and software must also remain
up-to-date. Extensions of external drug libraries are usually a top priority for future developments. Many new psychoactive substances and synthetic cannabinoids break into the market at a rapid pace, so are not all included in the current libraries.
Laboratories are able to add substances to the Toxtyper™ library themselves but for urine samples, metabolites are required and cannot be bought like the parent substances. Updates to urine metabolite libraries are, therefore critical to the continued success of toxicology laboratories.
About The Author
Rohan Thakur, Executive Vice President at Bruker Daltonics. Dr Thakur has over 20 years of experience in mass spectrometry, including 14 years in MS development and has several patents in the field of ion optics. During his career he held positions as Director Global Marketing for mass spectrometry solutions at Thermo and was Director of Drug Discovery at a Pharma CRO for 2 years before joining Bruker. Dr Thakur received his PhD in Chemistry from Kansas State University and did post-doctoral studies at Rutgers University, where his work involved using high-resolution MS analysis to prove the formation of ring- opened benzene metabolite-DNA and protein adducts.
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