21 High Confidence Analysis of Complex Samples
Agilent Technologies, Inc introduced the Agilent 6540 Ultra- High-Definition (UHD) Accurate-Mass Quadrupole Time-of-Flight (Q-TOF) liquid chromatography/mass spectrometry (LC/MS) system at the 2009 ASMS conference. This benchtop system offers superior data quality and advanced analytical capabilities, enabling researchers to profile, identify, characterise and quantify low molecular-weight compounds and biomolecules with greater confidence.
The Agilent 6540 Q-TOF is by far the highest-performing benchtop Q-TOF on the market, delivering much better performance than comparable Q-TOF products without the inherent trade-offs in speed, dynamic range, isotopic fidelity and mass range that are required by orbitrap-based systems. Innovative Ion Beam Compression (IBC) and Enhanced Mirror Technology (EMT) produce ultra-high-definition mass accuracy and mass resolution while maintaining a benchtop format.
"While others have pursued a 'bigger must be better' approach to TOF flight tube development, Agilent has used advanced engineering to dramatically improve performance and maintain a benchtop-instrument format." said Ken Miller, Agilent Senior Global Marketing Director for LC/MS. "We've achieved huge gains in mass accuracy and resolution while maintaining our industry-leading sensitivity and dynamic range. And the system can run fast to generate accurate mass MS and MS/MS data for UHPLC analyses without the resolution loss suffered by orbitraps. This is the perfect system for state-of-the-art qualitative analysis in support of proteomic, metabolomic or non-targeted food safety and environmental studies."
The new 6540 UHD Q-TOF delivers industry-leading performance in the most important categories and also offers application-specific software packages to take full advantage of this exceptional data quality to improve results from proteomics, metabolomics and common screening applications.
Circle no. 364 Dictionary of 100 Times More Mass Accuracy
Cerno Bioscience has firmly established its groundbreaking leadership role in formula identification with GC/MS quadrupole instruments by its award-winning software product MassWorks. MassWorks employs Cerno’s patented calibration technology to equip unit mass resolution mass spectrometers with up to 100 times more mass accuracy and unparallel Spectral Accuracy through exact isotope modelling. Through MassWorks, customers can utilise unit mass resolution mass spectrometers to identify the formulas of unknown compounds. This function, before MassWorks, was usually reserved for more expensive high-resolution mass spectrometers.
Initial skepticisms regarding the formula ID performance on a unit mass resolution mass spectrometer were quickly dispelled when Cerno offered potential customers to test MassWorks’ efficacy through blind tests. MassWorks accurately identified one blind sample after another until it boasted a staggering 99% success rate. This great achievement not only impressed countless clients, but also boosted sales to a varied spectrum of industries, including pharmaceuticals, flavour and fragrance, chemicals, and petroleum. MassWorks has been recognised as the method of choice for unknown ID with GC/MS by many happy users around the world from North America and Europe to China and Japan.
Compared to LC/MS, accurate mass and formula determination for GC/MS is currently under-served by the MS vendors, which represents the largest installed base. Most high resolution and high mass accuracy systems such as FT ICR MS, Orbitrap, and qTOF are available only through LC/MS interface. The few available GC/TOF systems come with its high purchase and maintenance cost and large instrument footprints, compounded by detector dynamic range issues and the requirement of frequent recalibration.
MassWorks offers a highly accurate and hugely economical solution on the already existing quadrupole GC/MS systems in the users’ lab. Circle no. 365
Mass Spectrometry in Drug Metabolism and Pharmacokinetics
Next Generation Ion Trap and Orbitrap Mass Spectrometers
Thermo Fisher Scientific, Inc launched two new mass spectrometers at ASMS 2009, the Thermo Scientific LTQ Velos and LTQ Orbitrap Velos. The LTQ Velos™ features a new dual-pressure trap and advanced ion optics, making it the world’s fastest and most sensitive ion trap mass spectrometer. The unique dual-pressure trap technology features two discrete pressure regions that allow the decoupling of ion manipulation and detection. This enables the use of optimal pressures during analysis, increasing both scan speed and resolution.
The outstanding data quality and sensitivity of the LTQ Velos make it ideal for the analysis of complex mixtures, such as the identification of low level proteins and structural elucidation of metabolites in biological matrices.
The LTQ Velos can be upgraded to the LTQ Orbitrap Velos, allowing laboratories to extend their initial investment to include accurate mass and ultra-high resolution capabilities with no compromise to sensitivity and speed of analysis.
The LTQ Orbitrap Velos™ combines the industry leading Orbitrap™ mass analyser, a new Higher-Energy Collisional Dissociation (HCD) cell and dual-pressure trap technology to routinely deliver ultra-high resolution and accurate-mass data. With new features, Thermo Scientific LTQ Orbitrap technology remains the most comprehensive structural identification mass spectrometry instrument and the platform of choice for the most confident protein and metabolite identification, characterisation and quantitation.
The speed of the LTQ Velos-based mass spectrometers is ideal for coupling to U-HPLC systems, enabling researchers to identify more compounds in less time. “The new dual- pressure trap and advanced ion optics combine to deliver increased sensitivity, improved ion transmission, and more efficient trapping and fragmentation of ions,” said Iain Mylchreest, Vice President of Mass Spectrometry for Thermo Fisher Scientific. “These major enhancements result in the fastest and most sensitive ion trap and Orbitrap mass spectrometers for any application involving complex mixtures.”
Circle no. 366 Ragu Ramanathan (Editor)
Hardback • 390 pages Pub date: January 2009 ISBN: 9780471751588
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Mass Spectrometry Steve Down and Anthony Mallet
Paperback • 184 pages Pub date: October 2009 ISBN: 9780470027615
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Using Mass Spectrometry for Drug Metabolism Studies, Second Edition Walter A. Korfmacher (Editor)
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Mass Spectrometry:
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Rolf Ekman et. al. (Editors)
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LAB ASIA - NOVEMBER/DECEMBER 2009 - MASS SPECTROSCOPY FOCUS
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