Laboratory Products 73
Untreated Microplates for Growing Cells in Suspension
Porvair Sciences has announced a new range of 12-, 24-, 48- and 96 well format untreated polystyrene culture microplates for growing cells in stationary suspension or other applications where reduced cell attachment is desired.
Untreated polystyrene plates are the lab tool of choice for growing embryoid bodies and other cells where cell attachment needs to be reduced or avoided. Natural, unmodified polystyrene surfaces are hydrophobic and only bind cells and biomolecules through passive hydrophobic interactions.
Moulded from ultra-pure polystyrene in a class 100,000 cleanroom production environment, Porvair untreated culture plates are supplied with lids in individual sterile packs. The proprietary design of Porvair untreated culture plates includes raised well rims to reduce evaporation, a single position lid to avoid cross contamination and alphanumeric code marking to enable easy identification of individual wells.
MORE INFO. 158
MORE INFO. 157
Nanoparticle Tracking Analysis used to Develop Solutions for Cancer Diagnosis and Drug Delivery
NanoSight reports on how Nanoparticle Tracking Analysis, NTA, is being applied in the development of future diagnostic and theranostic solutions for early diagnosis, drug delivery and treatment of cancer at the School of Medicine and CRANN, Trinity College Dublin, Ireland.
Dr Adriele Prina-Mello is a Research Fellow at CRANN and a part-time lecturer at the School of Medicine, Trinity College Dublin. His research focuses on functional biomaterials, diagnostic devices, and multifunctional nanomaterials for theranostic solutions in the treatment of cancer.
Fundamental in this work is the understanding of particle size, size distribution and of hydrodynamic response of nanoparticles dependent on their degree of aggregation. Additionally, being able to measure zeta potential and track particle behaviour in viscous or physiologically relevant media, informs the increasing characterisation demands of the nanomedicine community. Here pressure is on tools providers to offer the most comprehensive and low volume testing of sometimes very ‘expensive’ samples.
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Dr Prina-Mello described the Nanomedicine team goals: "Our main motivation for such levels of characterisation is determined by the potential use, applicability, and safety aspect linked to nanosize materials. This allows for further modification of the particle surface coating/moieties in order to get closer to the suitable candidate for diagnostic, monitoring and therapeutic application for nanomedicine and or biomedical research and also clinical translation. Furthermore, we also need characterisation information as basic preliminary understanding, in order to address wider experimental screening based on pharmaceutical standards, necessary to identify potential nanoparticle as lead carrier candidates for drug delivery of therapeutics".
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Continuing, he noted the benefits of using NanoSight's NTA instrumentation in complement to other characterisation techniques: "NanoSight allows for the identification of heterogeneity in particle size, poly- dispersity and counting with simultaneous zeta potential measurement. Furthermore, the use of small sample volumes compared to other techniques allows for cost effective, daily and routine characterisation."
MORE INFO. 159
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