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Nanoparticle Tracking Analysis used to Characterise Biomolecules at Lorraine University
NanoSight reports on how Nanoparticle Tracking Analysis, NTA, is being used in the research project ‘Engineering of Biomolecules’ at the Lorraine University, based in Nancy.
Dr Jordane Jasniewski works at the Laboratory of Biomolecules Engineering (LIBio) at Lorraine University, Nancy, and teaches in Food Chemistry at ENSAIA, an engineering school. He is a member of the research team working on the engineering of biomolecules to understand their structure and function to help develop new molecular architectures, to be applied in the areas of foods & agrichemicals, nutrition, pharmacology and cosmetics.
The expertise of LIBio allows the study of stabilisation, functionalisation and targeting of active molecules such as probiotics, antibacterial peptides, phenolic antioxidants and polyunsaturated fatty acids (PUFAs). Based on vectors of extremely rich marine DHA (docosahexaenoic acid, an omega-3 fatty acid), new dairy matrices, phospholipids and biopolymers are being developed.
Dr Jasniewski described the reasons for his selection of NTA for the measurement of the hydrodynamic diameter, Dh, of his nano-emulsion samples: "Our samples, which include polysaccharides, milk proteins and lecithins, are polydisperse. Having used dynamic light scattering, DLS, without success, we decided on NTA as it makes measurements on a particle-by-particle basis and does not need the refractive index to determine Dh. We can also readily measure the concentration of our samples and data is produced in a convenient way to export and use for further study."
To find out about the company and to learn more about particle characterisation using NanoSight's unique Nanoparticle Tracking Analysis solutions, visit
www.nanosight.com and register to receive the next issue of NanoTrail, the company's electronic newsletter.
New Solution for Optical Foam Structure Analysis Launched
Krüss GmbH presented a new module for the DFA100 Dynamic Foam Analyzer intended for the optical testing of fluid foam structures at the European Coatings Show 2013 in Nuremberg. The instrument uses image analysis to determine the number, size and size distribution of the bubbles of a foam generated under control in the instrument. The foam structure module features a height-adjustable camera with rapid image sequence for measuring the structural changes over time, thus making the inner destabilisation of the foam visible long before it actually decays.
Torben Schörck, Head of Development at Krüss, sees key applications for this new development in the food, cosmetics and cleaning agent industries, where the tactile properties linked with bubble structure play a role in addition to foam stability. “In particular customers from the brewery branch already showed an interest during the preliminary stages of the development. We are expecting further positive response from our upcoming trade fair appearances,” explained Schörck. Presentations at the CESIO in Barcelona and SEPAWA in Fulda are among those planned for 2013. The Company is well-established on the market for tensiometers and contact angle measurement instruments. In 2010 it opened a new product segment with the launch of its foam analysis instrument DFA100. Initially this modular instrument focused on measuring the decay of instable foams. A component for measuring liquid content presented in 2012 plus the new optical module are both geared towards stable and metastable foams.
MORE INFO. 139 Expansion of Product Range for Epigenetics
Porvair Sciences has announced the addition of the novel Chromatrap chromatin immunoprecipitation (ChIP) assay range to its portfolio of products for epigenetics.
Developed in conjunction with Department of Life Sciences at University of Swansea, UK - Chromatrap® uses a solid phase porous polymer functionalised with protein A, allowing the chromatin capture to be more efficient than bead based methods. The Chromatrap spin column approach offers significant advantages compared to methods based on sepharose or magnetic beads, which involve many steps of separation, pipetting and re-suspension. Independent tests with Chromatrap demonstrate levels of DNA pull down up to 25 times higher than with traditional bead based procedures, excellent DNA enrichment with signal-to-noise ratios typically 2 to 3 times better than competing procedures and top performance even with samples as small as 50ng or as much as 3000ng chromatin per immunoprecipitation.
Steve Knight, Sales & Marketing Director for Porvair Sciences commented “Early adopters of ChromaTrap in pharmaceutical, healthcare and academic research have been delighted at the increased efficiency and precision they can routinely achieve compared to traditional bead-based ChIP technologies.” He added “Not only are we adding an exciting new technology to our range of life science products but we are investing in the expertise of Dr Amy Beynon who has a PhD in Neuroscience to support customers in this expanding area of research. As our Applications Development Manager, Dr Beynon will be best placed to support our worldwide Chromatrap users with optimising their protocols to achieve the significant improvements in recoveries possible with the revolutionary Chromatrap technology."
MORE INFO. 140 MORE INFO. 138
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