Wake Forest’s program benefi ts
from the Wake Forest Institute for Regenerative Medicine (WFIRM) and its director, Anthony Atala, MD. The WFIRM team was the fi rst in the world to engineer laboratory-grown organs that were successfully implanted into humans. Wake Forest provides unique opportunities for those interested in working to develop printed tissues and organs through opportunities to conduct research at WFIRM. Their Summer Scholar program for undergraduate students exposes them to an integrated approach driven by clinic needs in regenerative medicine developments. Graduate students from several Wake Forest School of Medicine pro- grams including molecular medicine, molecular genetics, and b iomedical engineering, are eligible to conduct their thesis research at WFIRM. Probably one of the most exceptional opportunities avail- able is the Forsyth Technical Community College Internship program. Associate degree students in applied sciences in biotechnology are eligible to gain practical research labora- tory experience at WFIRM. Forsyth’s biotechnology program is designed to meet the skilled laboratory technicians with an emphasis on biology, chemistry, mathematics, and technical communications. This integrated approach is ideal for the semester-long WFIRM internship. Forsyth students work with WFIRM faculty and research fellows on tissue engineering and regenerative medicine. Through this, they gain fi rst-hand knowledge of the need for both biology and engineering to continue to develop replacement tissues and organs. Moving forward, the Wake Forest program and WFIRM
are likely to continue the integration of biology and engineering. According to Atala, “Because of the precision and reproducibility that it allows, 3D bioprinting will be an important factor in moving the science of regenerative medicine forward and making therapies available to larger groups of patients. Like other methods of tissue engineering, success at 3D bioprinting requires teamwork by a variety of disciplines, from cell biology and engineering to biomaterial sciences and physiology.” The other good example of biology and engineering
together, the University of Michigan, has a true collaboration between the top-rated School of Medicine and the top-rated School of Engineering. Their biomedical engineering pro- gram offers an interdisciplinary environment and training in
a wide range of programs includ- ing a graduate-level program in tissue engineering. In addition to the bioengineering-dedicated facilities, the biomedical engineering integration
provides access to both the School of Engineering and Medical School facilities. Together, with the University of Michigan
Health System including C.S. Mott Children’s Hospital, this collaborative environment has allowed Michigan to become a leader in applying all types of 3D printing technologies to medicine. One example is the successful implant of a tracheal splint 3D printed from polycaprolactone for an infant with a collapsed bronchus in 2012. The integrated team was led by Glenn Green, MD, and Scott Hollister, PhD, professor of biomedical engineering and mechanical engineering and associate professor of surgery. While these programs are terrifi c examples and making strides, there are other ways biologists and engineers can improve their ability to integrate including: If you’re engineer, take a biology course or two at your local community college. Start to learn to speak a bit of their language. If you’re a biologist, fi nd an engineer, particularly a manu- facturing engineer experienced in 3D printing to act as a mentor, to help you understand “engineering speak.” Find gatherings where these two groups gather like SME’s Medical Manufacturing Innovations program at RAPID 2015. (
www.sme.org/mmi)
As the applications of additive manufacturing get closer to the complexity of replacement tissues and organs, this collabor- ative approach will be critical to the many challenges ahead. NOTE: For more information on the challenges of bioprint- ing, please see the 2015 Medical Manufacturing Yearbook article: “Bioprinting: 3D Printing Comes to Life,” by Anthony Atala, Director; and James Yoo, Professor and Chief Scien- tifi c Offi cer, Wake Forest Institute for Regenerative Medicine at
http://tinyurl.com/smebioprinting.
Lauralyn McDaniel Industry Manager, Medical SME
June 2015 |
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