Adjuvantage Murray
and audits these elements of vaccinati on in an eff ort to ensure that vaccine is administered correctly and consistently. The second, and perhaps less tangible, aspect
to successful vaccinati on lies in the make-up of the vaccine itself. It is a widely held belief that vaccine potency and effi cacy is related to the extent of the physical side eff ects, which can become apparent a couple of months following the injecti on of an oil-based vaccine. To some extent this is true. The part of the
fi sh’s immune system which responds to the vaccine is triggered by the adjuvant. Principally, this involves an infl ux of innate immune cells to sites where the vaccine dose has been deposit- ed. Through interacti ons with the anti gen-adju- vant complex, these cells sti mulate other cells to produce anti body as part of the primary immune response and, importantly, for the quick estab- lishment of a secondary response should the fi sh encounter similar anti gens later in its life. It is the infl ux of innate immune cells and the
ensuing infl ammatory response that has been associated with so-called vaccine side eff ects, which include granulomas, adhesions and in some cases melanisati on. In cases where these side eff ects are severe
and quick to develop, the welfare of vaccinated fi sh may be compromised; they may take many
days to resume normal feeding behaviour and they can oft en be left prone to parasiti c and fungal infecti ons. But is it possible to generate a robust and long
lasti ng immune memory without the inducti on of risky side eff ects which can oft en persist unti l harvest, at which point aff ected carcasses may be downgraded? Pharmaq believes it is. Many years of detailed
research into the complex interplay between an- ti gens and adjuvants, and how they are blended opti mally, have produced a highly sophisti cated formulati on technology platf orm upon which the company has based its suite of injectable vaccines. From Gemma Murray’s perspecti ve, these
vaccines can be deployed in the knowledge that not only will they deliver the immunity required by her customers in the marine environment, but will do so without costi ng her days of lost feed- ing, along with the associated risks from ectopic pathogens. So it really is possible to ‘have your cake and
eat it’ which, incidentally, you can also do in a more literal sense on the Pharmaq stand (D355) each aft ernoon at 14.00 at AquaNor 2015!
Chris Mitchell is Pharmaq’s nati onal sales man- ager. FF
PHARMAQ Ltd, Unit 15, Sandleheath Ind Est, Fordingbridge, SP6 1PA Tel: 01425 656081
www.pharmaq.com
www.fishfarmer-magazine.com 23
See us on stand D355 at AquaNor
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