CATTLE RAISERS COMMUNITY
(enrofloxacin) 100 ANADA 200-495, Approved by FDA
Enroflox®
100 mg/mL Antimicrobial Injectable Solution
For Subcutaneous Use in Beef Cattle, Non-Lactating Dairy Cattle and Swine Only.
Brief Summary: Before using Enroflox® 100, consult the product insert, a summary of which follows.
CAUTION: Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed veterinarian. Federal (U.S.A.) law prohibits the extra-label use of this drug in food-producing animals.
PRODUCT DESCRIPTION: Each mL of Enroflox 100 contains 100 mg of enrofloxacin. Excipients are L-arginine base 200 mg, n-butyl alcohol 30 mg, benzyl alcohol (as a preservative) 20 mg and water for injection q.s.
INDICATIONS:
Cattle - Single-Dose Therapy: Enroflox 100 is indicated for the treatment of bovine respiratory disease (BRD) associated with Mannheimia haemolytica, Pasteurella multocida, Histophilus somni and Mycoplasma bovis in beef and non-lactating dairy cattle; and for the control of BRD in beef and non-lactating dairy cattle at high risk of developing BRD associated with M. haemolytica, P. multocida, H. somni and M. bovis.
Cattle - Multiple-Day Therapy: Enroflox 100 is indicated for the treatment of bovine respiratory disease (BRD) associated with Mannheimia haemolytica, Pasteurella multocida and Histophilus somni in beef and non-lactating dairy cattle.
Swine: Enroflox 100 is indicated for the treatment and control of swine respiratory disease (SRD) associated with Actinobacillus pleuropneumoniae, Pasteurella multocida, Haemophilus parasuis and Streptococcus suis.
calves. Do not use in calves to be processed for veal. Swine: Animals intended for human consumption must not be slaughtered within 5 days of receiving a single-injection dose.
Cattle: Animals intended for human consumption must not be slaughtered within 28 days from the last treatment. This product is not approved for female dairy cattle 20 months of age or older, including dry dairy cows. Use in these cattle may cause drug residues in milk and/or in calves born to these cows. A withdrawal period has not been established for this product in pre-ruminating
RESIDUE WARNINGS:
HUMAN WARNINGS: For use in animals only. Keep out of the reach of children. Avoid contact with eyes. In case of contact, immediately flush eyes with copious amounts of water for 15 minutes. In case of dermal contact, wash skin with soap and water. Consult a physician if irritation persists following ocular or dermal exposures. Individuals with a history of hypersensitivity to quinolones should avoid this product. In humans, there is a risk of user photosensitization within a few hours after excessive exposure to quinolones. If excessive accidental exposure occurs, avoid direct sunlight. For customer service, to obtain a copy of the Material Safety Data Sheet (MSDS) or to report adverse reactions, call Norbrook at 1-866-591-5777.
PRECAUTIONS:
The effects of enrofloxacin on cattle or swine reproductive performance, pregnancy and lactation have not been adequately determined.
Not for Use in Female Dairy Cattle 20 Months of Age or Older Or In Calves To Be Processed For Veal.
BEREAVEMENTS
John Burton Barnes III, 48, San Antonio, died Jan. 21. He was born March 11, 1967, to Elizabeth McClelland Barnes and John Burton Barnes, Jr. He
grew up in San Antonio, graduating from Alamo Heights High School in 1985. He earned his college degree from the University of Texas at Austin. Fol- lowing his father’s footsteps, he worked a lifelong career in insurance at Eichlitz Dennis Wray and Westheimer, later Wortham Insurance, where he rose to managing partner. He is survived by his wife Margaret Marshall Barnes; son John Burton Barnes IV; daughter Bracken West Barnes; and numerous other relatives. Memorials may be sent to the Texas Cavaliers Charitable Foundation, Post Offi ce Box 6927, San Antonio, Texas 78209 or the Bryan Museum, 1315 21st St., Galveston, Texas 77550. Robert “Bob” C. Berger, 75, died Jan. 25, in Wichita Falls. He was born Feb. 3, 1940, in Wichita Falls to Peter and Lula E. (Martin) Berger. He graduated
from Wichita Falls High School and then attended Texas A&M University, graduating with a Bachelor of Science degree in petroleum engineering. He worked in various engineering and managerial capacities for Skelly Oil Com- pany, Getty Oil Company, Texaco Inc. and Memorial Exploration for 35 years, and managed the family farm upon his parents passing. He is survived by his wife Ann and daughter Jana Smith, Allen; and numerous other relatives. Ann Gilbert Elliott, 85, Seymour, died Dec. 28, 2015. She was born June 21, 1930, in Seymour, 1 of 9 children of Robert Morris and Grace Avery Gilbert.
The long-term effects on articular joint cartilage have not been determined in pigs above market weight. Subcutaneous injection can cause a transient local tissue reaction that may result in trim loss of edible tissue at slaughter. Enroflox 100 contains different excipients than other enrofloxacin products. The safety and efficacy of this formulation in species other than cattle and swine have not been determined. Quinolone-class drugs should be used with caution in animals with known or suspected Central Nervous System (CNS) disorders. In such animals, quinolones have, in rare instances, been associated with CNS stimulation which may lead to convulsive seizures. Quinolone-class drugs have been shown to produce erosions of cartilage of weight-bearing joints and other signs of arthropathy in immature animals of various species. See Animal Safety section for additional information.
ADVERSE REACTIONS: No adverse reactions were observed during clinical trials.
ANIMAL SAFETY:
In cattle safety studies, clinical signs of depression, incoordination and muscle fasciculation were observed in calves when doses of 15 or 25 mg/kg were administered for 10 to 15 days. Clinical signs of depression, inappetance and incoordination were observed when a dose of 50 mg/kg was administered for 3 days. An injection site study conducted in feeder calves demonstrated that the formulation may induce a transient reaction in the subcutaneous tissue and underlying muscle. In swine safety studies, incidental lameness of short duration was observed in all groups, including the saline-treated controls. Musculoskeletal stiffness was observed following the 15 and 25 mg/kg treatments with clinical signs appearing during the second week of treatment. Clinical signs of lameness improved after treatment ceased and most animals were clinically normal at necropsy. An injection site study conducted in pigs demonstrated that the formulation may induce a transient reaction in the subcutaneous tissue.
Norbrook Laboratories Limited,
The Norbrook logos and Enroflox® are registered trademarks of Norbrook Laboratories Limited.
28 The Cattleman March 2016
Newry, BT35 6PU, Co. Down, Northern Ireland I01 March 2015
She married Manford Elliott, long-time TSCRA special ranger, on December 22, 1946. She retired from the Farmers National Bank after 30 years, and was a member of the First United Methodist Church. She is survived by her children, Bob Elliott, Seymour; Bill Elliott, Tucumcari, N.M.; Gilbert “Cotton” Elliott, Guthrie; and Cindy Layton, Benjamin; son-in-law, Tom Moorhouse, Benjamin; and numerous other relatives. George Asa Jones, 96, San Angelo, died Jan. 2, 2016. He was born in San Antonio on Aug. 25, 1919. He graduated from Texas A&M in 1940 with a
Bachelor of Science degree in agricultural administration, and was com- missioned as a lieutenant in the U.S. Army Cavalry. He married Nanette Leeman Todd on Feb. 11, 1943, in Fort Riley, Kan. Jones grew up ranching on the east end of what is today Big Bend National Park, and on the Double Circles Cattle Co. in Arizona. While at A&M, he was a member of the Corp of Cadets and Captain of the A&M Polo team. He served as Horse Cav- alry Unit Commander in Northern Africa and Central Europe during WWII, where he was instrumental in liberating and protecting the Lipizzaner stallions. He earned the rank of Major. He ranched in West Texas and New Mexico and operated the Deming Livestock Auction. He is survived by son Ross D. Jones, Fort Stockton; daughter Molly J. Walker, San Angelo; and numerous other relatives. Ann B. Milam, Fort Worth, 89, died Jan. 1. She was born Sept. 13, 1926, in Bald Prairie. She was a long-time member of the staff of Texas and South-
western Cattle Raisers Association, in the market information department. She is survived by her daughters; Carol Dunn, Cheryl Williams and Bobbie Mayfi eld; and numerous other relatives.
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