» XRD
»
characterization of crystalline and amorphous materials using thermal analysis, x-ray diffraction, and physisorption techniques.
Jeff Brum, Ph.D. received his Ph.D. in physical chemistry from Tulane University.
He started with GlaxoSmithKline in 1994, and is currently
team leader of the physical properties group in Collegeville PA. Prior to joining GSK he was a National Research Council Postdoctoral Fellow at the National Institute of Standards and Technology.
Glenn R. Williams, Ph.D. is interested in solid-state characterization of amorphous and crystalline pharmaceutical materials (active drug substances, excipients, and drug products). In particular, he has been focused on x-ray diffraction, x-ray fluorescence, microscopy, thermal analysis, and molecular spectroscopy. He has over 12 years of solid-state analysis experience in the pharmaceutical industry from both the brand and generic perspectives.
Frederick G. Vogt, Ph.D. is a patent attorney at Morgan, Lewis & Bockius, LLP. His scientific interests include NMR, x-ray diffraction, and vibrational and molecular spectroscopy, as applied to drug substance crystallization and form control, drug product and excipient characterization and secondary manufacturing processes, and patent support. He has more than 10 years of experience in these fields and has contributed to more than 50 peer-reviewed publications and five book chapters involving spectroscopy and solid-state analysis.
2. 3. 4. 5. 6. 7. 8. 9.
References 1.
N.S. Trasi, S.X.M. Boerrigter, S.R. Byrn, “Investigation of the milling-induced thermal behavior of crystalline and amorphous griseofulvin” Pharm Res 27 (2011)
T. Feng, R. Pinal, M.T. Carvajal “Process induced disorder in crystalline materials: differentiating defective crystals from the amorphous form of griseofulvin” J Pharm Sci 97 (2008)
K.J. Crowley, G. Zografi “Cryogenic grinding of indomethacin polymorphs and solvates: assessment of amorphous phase formation and amorphous physical stability” J Pharm Sci 91 (2002)
S. Chattoraj, C. Bhugra, C. Telang, L. Zhong, Z. Wang, C. Sun “Origin of two modes of non- isothermal crystallization of glasses produced by milling” Pharm Res 29 (2012)
L. Zhu, J. Jona, K. Nagapudi, T. Wu ”Fast crystallization of griseofulvin below Tg” Pharm Res 27 (2010)
T. Wu, Y. Sun, N. Li, M.M. deVilliers, L. Yu “Inhibiting surface crystallization of amorphous indomethacin by nanocoating” Langmuir 23 (2007)
P. Scherrer, “Bestimmung der Grösse und der inneren Struktur von Kolloidteilchen mittels Röntgenstrahlen,” Nachr. Ges. Wiss. Göttingen 26 (1918)
E.A. Van Arkel “Deformation of the crystal lattice of metals by mechanical working” Physica 5 (1925)
G.K. Williamson, W.H. Hall “X-ray line broadening from filed aluminium and wolfram” Acta Metall (1953)
The Use of Control Strains for the Quality Control Testing of Culture Media
The safety and efficacy of a pharmaceutical product is dependent on the quality and sensitivity of required pharmacopoeial testing procedures. As many of these procedures analyze products for microbial growth, it is essential that the quality control of associated microbial culture media is upheld throughout growth promotion testing using authenticated microbial control strains.
This webinar will highlight:
• An overview on the use of microbial culture media in pharmaceutical quality control testing
• The required microbial testing strains for commonly used media and best practices to handle these strains within the laboratory
Speakers: Tim Sandle
Head of Microbiology UK Bio Products Laboratory
Liz Kerrigan Director, Product Development ATCC
View this webinar ON DEMAND at:
www.americanpharmaceuticalreview.com/ATCCwebinar
46 | | September/October 2013 - 15TH ANNIVERSARY ISSUE
ON DEMAND WEBINAR
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