26 JAAHA /
jaaha.org
CASE REPORTS
Systemic Mycosis in Three Dogs from Non-endemic Regions
CL Pratt, RK Sellon, ES Spencer, TW Johnson, DJ Righter
ABSTRACT Three dogs were examined for clinical signs ultimately attributed to systemic fungal infections. One dog was evaluated for chronic, ulcerated dermal lesions and lymphadenomegaly; one dog was examined for acute onset of unilateral blepharospasm; and one dog had diarrhea and hematochezia. Two of the dogs were diag- nosed with blastomycosis (one with disseminated dis- ease and the other with the disease localized to the left eye). The third dog was diagnosed with disseminated histoplasmosis. None of the dogs originated from, or had traveled to, typical regions endemic for these fungal diseases. All diagnoses were established from histopa- thology and either polymerase chain reaction (PCR) or cytology and culture. The two dogs diagnosed with blas- tomycosis were treated with either itraconazole or keto- conazole with apparent resolution of the infections. The dog with ocular involvement had an enucleation prior to beginning therapy. The dog diagnosed with histoplas- mosis was euthanized without treatment. In patients with characteristic clinical features, systemic fungal in- fections should still be considered as differential diagnoses regardless of their travel history.
CASE REPORTS
Adrenocortical Carcinoma in a Dog with Incomplete Excision Managed Long-term with Metastasectomy Alone
JL Frankot, EN Behrend, P Sebestyen, BE Powers
ABSTRACT A 10 yr old bichon frise presented with a 3 mo history of polyuria, polydipsia, and hind limb weakness. Serum bio- chemistry revealed persistent hypokalemia. A left adre- nal gland mass with right adrenal atrophy was detected ultrasonographically. Basal serum cortisol concentra- tion was at the low end of normal (30 nmol/L; reference range, 30–140 nmol/L) and adrenocorticotropic hormone (ACTH)-stimulated cortisol concentration was low (199 nmol/L; reference range, 220–470 nmol/L). Basal serum 17-a-OH progesterone concentration was also low (0.03 ng/mL; reference range, 0.06–0.30 ng/mL), but the aldo- sterone concentration 2 hr after the ACTH stimulation was elevated (> 3,000 pmol/L; reference range, 197–2,103 pmol/L). A left adrenalectomy and nephrectomy were per- formed. Histopathology revealed an adrenocortical zona glomerulosa carcinoma. Surgical excision was considered incomplete; however, clinical signs resolved. Two years later, basal and ACTH-stimulated aldosterone concentra- tions were
elevated.Computed tomography demonstrated a mass effect in the liver. The left lateral and left medial he- patic lobes were removed. Histopathology confirmed met- astatic endocrine carcinoma. The patient was stable 1,353 days postsurgically (when this report was prepared). This is the first case report of a metastatic adrenal carcinoma that was successfully managed surgically for > 3 yr.
ABSTRACT This report describes the simultaneous occurrence of an ovarian teratoma and a granulosa cell tumor (GCT) with intraabdominal metastasis in a 1.5 yr old female Doberman pinscher. At surgery, a 20 cm, smooth, intact mass associated with the left ovary and multiple 1–2 cm irregular masses in the broad ligament were found. The masses were surgically removed and submitted for his- topathology. A histologic diagnosis of a teratoma and a GCT with broad ligament metastasis was made. Further treatment was elected by the owner and included two cycles of carboplatin therapy. The dog was euthanized 6 wk postoperatively for signs related to metastasis and dyspnea. Teratoma of the ovary, although it contains derivatives of all three embryonic germ cell layers, rarely presents together with either ovarian epithelial or sex cord-stromal tumors. To the authors’ knowledge, this is the first reported case of an ovarian teratoma coexisting with a primary GCT with intra-abdominal metastasis in the same ovary in a dog.
CASE REPORTS
Primary Ovarian Teratoma and GCT with Intra-abdominal Metastasis in a Dog JD Coggeshall, JN Franks, DU Wilson, JL Wiley
JAAHA is available in print and online. Log on to
jaaha.org for more information. Trends magazine, November 2012
Page 1 |
Page 2 |
Page 3 |
Page 4 |
Page 5 |
Page 6 |
Page 7 |
Page 8 |
Page 9 |
Page 10 |
Page 11 |
Page 12 |
Page 13 |
Page 14 |
Page 15 |
Page 16 |
Page 17 |
Page 18 |
Page 19 |
Page 20 |
Page 21 |
Page 22 |
Page 23 |
Page 24 |
Page 25 |
Page 26 |
Page 27 |
Page 28 |
Page 29 |
Page 30 |
Page 31 |
Page 32 |
Page 33 |
Page 34 |
Page 35 |
Page 36 |
Page 37 |
Page 38 |
Page 39 |
Page 40 |
Page 41 |
Page 42 |
Page 43 |
Page 44 |
Page 45 |
Page 46 |
Page 47 |
Page 48 |
Page 49 |
Page 50 |
Page 51 |
Page 52 |
Page 53 |
Page 54 |
Page 55 |
Page 56 |
Page 57 |
Page 58 |
Page 59 |
Page 60 |
Page 61 |
Page 62 |
Page 63 |
Page 64 |
Page 65 |
Page 66 |
Page 67 |
Page 68