Laboratory Products 11


ChIP Kits for High Throughput Antibody Validation


Covid-19 Bio-Safety Enclosure for Liquid Handling Automation


Bigneat offers a specialised range of Laboratory Automation Enclosures for use with liquid handling platforms / robotics, capable of meeting high-throughput requirements.


The LAC2 Class II type enclosure, is designed and constructed following years of experience and provides for operator and sample/process protection (sterility) with doors in closed or open conditions.


An unprecedented demand has resulted in Bigneat increasing its manufacturing and production capacity dramatically over the last few months. The company are proud to be a supplier to the many sites around the globe that already have their enclosures in place to aid in the Covid-19 tests being conducted.


As with all of their products, Bigneat does not operate on a ‘one size fi ts all’ strategy. Get in touch should you wish to fi nd out more.


From the conceptual design phase through to customer engagement, manufacturing and installation of the enclosures, Bigneat are able to ensure that customers achieve the very best performance from their system and process whilst ensuring ease of access to the enclosure interior for in-situ maintenance of installed instrumentation and robotics.


Bigneat enclosures provide excellent visibility of the enclosed system. More information online: ilmt.co/PL/MmRD


Porvair Sciences reports how its Chromatrap® ChIP kits provide an outstanding solution for antibodies suppliers looking to validate the performance of the antibodies they produce for chromatin immunoprecipitation (ChIP) assay kits.


With its revolutionary bead-free system, Chromatrap®


offers a faster, easier and more


sensitive method to validate antibodies in a high throughput format. This enables antibody suppliers to easily and effi ciently expand their product portfolio to target epigenetics and drug development applications.


Successful ChIP assays heavily rely on the highest quality antibodies. In-house validation of antibodies for use in ChIP is considered to be a lengthy, expensive, time consuming and challenging process. In addition, antibodies are rigourously assessed for enrichment of positive and negative gene targets, signal-to-noise ratio, chromatin-to-antibody ratio, reproducibility and lot-to-lot variations.


Dr Lindsay Parkes, a senior research scientist at Porvair Sciences commented: “We have developed our bead-free Chromatrap® technology to enable maximum capture of antibody. This is achieved by correctly orientated capture proteins throughout the inert fi lter-based ChIP technology. Most bead- based systems have capture proteins scattered in random orientation which doesn’t allow full access of antibodies to binding pockets of proteins, thus giving an overall reduced capture effi ciency. This is important for high sensitivity especially for detection of binding of low abundant targets.”


Chromatrap® ChIP kits deliver fast workfl ow,


enabling you to process up to 96 ChIP assays simultaneously in just one day allowing multiple sample, antibody and gene targets to be tested in parallel on a single plate. Requiring less manual handling and fewer pipetting steps than other ChIP kits, Chromatrap®


ChIP kits


are very easy to use, making them perfect for even inexperienced users. Using these kits, a complete ChIP protocol doesn’t require overnight incubation or blocking steps and can be completed in under fi ve hours. Chromatrap® ChIP-kits are suitable for use over a wide chromatin enrichment range (500ng - 50µg).


More information online: ilmt.co/PL/kGXA 52533pr@reply-direct.com


52566pr@reply-direct.com New Generation Automated Raman Imaging Microscope Introduced


WITec GmbH establishes the next level of automation and user-friendliness with the introduction of the new alpha300 apyron. Its AutoBeam technology unlocks the full potential of WITec’s industry-leading alpha300 series. The alpha300 apyron’s entirely new optical, analytical and remote operation capabilities mark the furthest advance yet in speed, sensitivity and resolution.


The alpha300 apyron can self-align and self-calibrate, which substantially reduces the researcher’s experimental workload by requiring less user input, enhancing reproducibility and eliminating potential sources of error. This is made possible by a complete set of WITec’s AutoBeam opto-mechanical components, a new and versatile tool kit that can be confi gured to create the perfect experimental setup for every investigation.


New functionalities provided by AutoBeam modules include polarisation-dependent


measurements with motorised polariser and analyser rotation, push-button spectrometer connection and signal maximisation, and automated adjustment of both iris diaphragms. Software-driven automation also allows the alpha300 apyron to be operated completely remotely, whether in an environmental enclosure such as a glove box, or from another location.


Available with a wide variety of excitation wavelengths from the ultraviolet through the visible into the near infrared, alpha300 apyron microscopes can be equipped with up to three ultra-high throughput WITec UHTS spectrometers and their accompanying range of detectors. Raman imaging and correlative measurements are defi ned, executed, saved and evaluated with WITec’s Suite FIVE software and intuitive EasyLink handheld controller.


WITec began automating Raman imaging measurements with the fi rst generation apyron. Its advanced technology was introduced to the alpha300 line in stages of spiral development. The new consolidated alpha300 series is a continuous spectrum, from the entry-level access up to the fl agship apyron. They all share the same rock-solid stability, fi bre-based fl exibility and integrated software environment.


The user-friendliness of the alpha300 apyron makes advanced confocal Raman imaging accessible to researchers of all experience levels and fi elds of application. Scientists working in materials science, environmental science and microparticle analysis, life science, food science, geology, pharmaceutics and many other fi elds will benefi t from automated alignment routines that provide consistently optimised performance. The alpha300 apyron accelerates both the experimental setup and subsequent measurement workfl ow.


More information online: ilmt.co/PL/xQrB 52114pr@reply-direct.com


To advertise with us please contact our sales team on


+44 (0)1727 855574 WWW.LABMATE-ONLINE.COM


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