9 Mass Spectrometry
New, Versatile High-Resolution Mass Spectrometer Expands Market-leading Platform
The Thermo Scientific Orbitrap Exploris 240 mass spectrometer expands the proven Orbitrap Exploris platform and delivers mass accuracy, sensitivity and resolving power across a wide dynamic range. With new-generation system architecture and instrument control software, the system provides simple yet powerful data acquisition capabilities, addressing the most demanding analytical challenges for small- and large-molecule applications. The system offers positive/negative mode switching for comprehensive sample coverage, fast scan speeds and functionalities including Thermo Scientific AcquireX intelligent data acquisition workflow that enable greater automation.
“Scientists are seeking technologies that can streamline and speed proteomics studies to clinical applications, reduce time to market for candidate biotherapeutics and address the growing challenge of characterising novel chemical entities in small-molecule studies,” said Iain Mylchreest, Vice President, Research and Development, Analytical Instruments, Thermo Fisher Scientific. “As part of our expanded portfolio of new-generation instruments, the Orbitrap Exploris 240 mass spectrometer delivers the high performance and versatility needed to drive productivity across multiple applications.”
Dr Timothy Garrett, Associate Professor, Department of Pathology, Immunology and Laboratory Medicine, co-director of the Southeast Center for Integrated Metabolomics, University of Florida, said: “Using the Orbitrap Exploris 240 mass spectrometer has been extremely user friendly, with one-click calibration and method templates for fast instrument setup. The system reproducibility in mass accuracy and peak integrated area over several sample batches and several days of acquisition has been impressive. This is very important for our large-scale metabolomics projects enabling minimum post-acquisition data manipulation to yield high quality results.”
The Thermo Scientific Orbitrap Exploris portfolio of high-resolution, accurate-mass (HRAM) systems, which launched in 2019 with the Thermo Scientific Orbitrap Exploris 480 mass spectrometer, now includes two new, highly capable instruments, the Thermo Scientific Orbitrap Exploris 240 and Thermo Scientific Orbitrap Exploris 120 mass spectrometer, allowing customers to easily transfer knowledge and methods from research and discovery to routine testing. The Orbitrap Exploris 480 and 240 mass spectrometers are fully compatible with the Thermo Scientific FAIMS Pro interface to achieve enhanced identification of proteins and peptides. Improved quantitative performance for translational proteomics and high-throughput studies will enable researchers to accelerate the translation of discoveries into clinical applications.
Performance of the Orbitrap Exploris 240 mass spectrometer is further enhanced with access to powerful new software functionality to improve data acquisition and processing. Proteomics scientists will benefit from the latest artificial intelligence (AI) technology with Thermo Scientific Proteome Discoverer 2.5 software. The new release utilises deep learning tools to provide a more accurate prediction of mass spectra, improving confidence in peptide identification, supporting scientists developing new biopharmaceuticals, Thermo Scientific BioPharma Finder 4.0 software delivers enhanced flexibility for the analysis of intact proteins, sub-unit mass analysis, peptide mapping and oligonucleotide analysis. Direct transfer of data processing parameters to Thermo Scientific Chromeleon Chromatography Data System (CDS) software enables compliance-ready analysis for peptide monitoring and quantitation of proteins.
With Thermo Scientific Compound Discoverer 3.2 software, small-molecule researchers are supported through extensive characterisation capabilities, access to multiple mass spectral fragmentation library and structural database sources. Access to the large Thermo Scientific mzCloud mass spectral fragmentation library enhances connectivity and characterisation for small molecule applications to help identify compounds.
The launch of Thermo Scientific Xcalibur 4.4 software brings the AcquireX intelligent data acquisition workflow to the Orbitrap Exploris family of mass spectrometers, allowing greater automation for structural identification and characterisation of small molecules.
More information online:
ilmt.co/PL/W3wQ Powerful Vacuum Pumps for Mass Spectrometer Systems
Hena 50 and 70 are single-stage, oil-sealed rotary vane pumps which were developed for the demanding requirements of mass spectrometer systems. They achieve pumping speeds of between 32 and 59 m³/h, depending on their size and speed of rotation. Their integrated oil mist separator ensures clean exhaust air. They are equipped with a frequency converter that enables them to be used worldwide with single-phase input and identical pump capacity for 50 and 60 Hz.
A constantly high flow rate in the target pressure range, adjustable pumping speeds and low final vacuum contribute to the instrument’s reliable high performance. Long maintenance intervals and operating hours are ensured by the high oil volume in the pumps and their low oil temperature during operation.
Hena 50 and 70 can increase the overall availability of the instrument through their high ruggedness and reliability. Additionally, they are easy to integrate due to their low noise level and efficient oil separation. Both Hena 50 and Hena 70 are certified according to UL and IEC 61010.
More information online:
ilmt.co/PL/XMqg 52593pr@reply-direct.com
Collaboration for Early Detection of Alzheimer’s Biomarkers Announced
Shimadzu introduces the collaboration with the Clinical Laboratory and Proteomics Platform of the CHU University Hospital of Montpellier, France. With the team of professors Sylvain Lehmann and Christophe Hirtz, they focus on MS based blood amyloid-beta analysis for early screening of amyloid-positive subjects. The cooperation plans to conduct a joint cohort study from the Memory Resources and Research Center (Professor Audrey Gabelle) to evaluate whether this simple blood analysis method enables early and accurate prediction of amyloid pathology in the brain with an easy-to-acquire blood sample.
Unlike conventional positron emission tomography (PET) imaging and cerebrospinal fluid (CSF) testing methods, Shimadzu’s blood amyloid-beta analysis method is minimally invasive and suitable for large-scale deployment. It is a new-approach blood analysis capable of being used for the research of detecting abnormal amyloid-beta concentration which can be a marker for amyloid pathology in the brain.
These new blood-based biomarkers were discovered in 2014 by Shimadzu and the Japanese National Center for Geriatrics and Gerontology (NCGG). Although the screening analysis is Research Use Only and cannot diagnose Alzheimer’s disease, it is ideal for opening the door to new advancements in research, identifying suitable candidates for clinical trials and helping
pharmaceutical company to test candidate drugs.
The blood analysis works using a combination of immunoprecipitation and MALDI-TOF mass spectrometry (IP-MS). This technique was first established by a team of scientists including Shimadzu’s Koichi Tanaka, who was awarded the Nobel Prize in Chemistry in 2002 for developing a method for mass spectrometric analysis of biological macromolecules.
The CHU of Montpellier is part of Shimadzu’s European Innovation Center (EUIC) program. The EUIC merges the cutting-edge analytical technologies of Shimadzu with game-changing topics and expertise in markets and science covered by opinion leaders, strategic thinkers and scientific experts in order to create new solutions for tomorrow.
More information online:
ilmt.co/PL/3kj0 W
www.HidenAnalytical.com
info@hiden.co.uk E
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Mass spectrometers for vacuum, gas, plasma and surface science pQA
Membrane Inlet Mass Spectrometer (MIMS) Features
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Transportable ruggedised case for field operation
12 V power input
User configurable inlets Multi gas/vapour analysis
Applications
Ground water studies Environmental research Denitrification studies
Oceanic gas measurements Intlet Options
Direct inlet probe
Flow through probe for rare earth gas studies Low volume MIMS inlet for denitrification studies
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Portable Quadrupole Analyser
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