33
organic acids, sugars, and sugar alcohols in plant tissue extracts as their trimethylsilyl derivatives, Anal. Biochem. 266 (1999) 77–84
7. C. Bruggink, J. Trick, C. Wanner, D. Jensen, Novel determination of organic acids in diesel and motor oil by ion chromatography, Anal. Lett. 50 (2016) 739–747
8. X. Geng, S. Zhang, Q. Wang, Z.K. Zhao, Determination of organic acids in the presence of inorganic anions by ion chromatography with suppressed
conductivity detection, J. Chromatogr. A 1192 (2008) 187–190
9. H.H. Willard, L.L. Merritt Jr., J.A. Dean, & F.A. Settle Jr. (1988). Instrumental methods of analysis, 7th edition. United States: Wadsworth Publishing Company.
10. M. C. Jin, X.-H. Chen, M.-Q. Cai, Y. Zhu, Eluent generator reagent free ion chromatography with electrospray ionization mass spectrometry for simultaneous analysis of organic acids in juices and beverages, Anal. Lett. 43 (2010) 2061–2077
11. ICH Q2 (R1) Validation of analytical procedures: text and methodology, 1994
12. Z. Lewis, B.A. Jackson, A. Crampton, A.D. Ray, S.W. Holman, Towards a generic method for ion chromatography/mass spectrometry of low-molecular-weight amines in pharmaceutical drug discovery and development, Rapid Communications in Mass Spectrometry (2020) e8680
Free Guide Tackles how to Combat Common GC Troubleshooting Issues
Instrument downtime is often costly and time consuming, but frequently the problems can be resolved quickly with some troubleshooting knowledge. Shimadzu UK are pleased to present this free GC Troubleshooting Guide designed to assist chromatographers assess and common GC problems. This also includes how to effectively troubleshoot and fix these issues.
This guide covers common subjects including: unstable baseline; carryover and ghost peaks; fronting or tailing peaks; poor resolution; retention time variability.
This useful guide can be conveniently downloaded from
www.shimadzu.co.uk/form/gc-poster.
The content is intended for researchers, analytical chemists, academics and lab users who want to develop their troubleshooting skills. Don’t delay - download your free copy now.
More information online:
ilmt.co/PL/pDRB
Highly Stable Detector Improves GPC/SEC Results
The Differential Refractive Index (DRI) detector from Testa Analytical Solution eK offers unmatched accuracy and reliability for determination of absolute concentration and total mass balance in Gel Permeation Chromatography/Size Exclusion Chromatography (GPC/ SEC) applications.
The baseline signal stability of any liquid chromatography detector is very important, as it is a limiting factor in peak determination. Detector stability gains even more importance where analysis time is long, such as is commonly encountered in high resolution GPC/SEC applications.
Use of multiple columns is common in GPC/SEC as a technique to increase resolution and also to increase the available dynamic range in terms of molecular weight. As such, high resolution GPC/SEC measurements can often take 30 to 60 minutes for a single separation. As a result, most HPLC detectors adapted for use in GPC/SEC will show a significant
baseline drift between the beginning and end of the chromatogram thus negatively influencing the ability to accurately determine the beginning and end of sample peaks and therefore to calculate the correct polydispersity.
Operating from room temperature up to 80°C with high thermal stability, Testa Analytical’s DRI detector has been designed with particular attention to eliminating drift. As a consequence of its unmatched baseline stability, the DRI detector delivers excellent performance for chromatographic separations of any duration.
More information online:
ilmt.co/PL/Go0y
Page 1 |
Page 2 |
Page 3 |
Page 4 |
Page 5 |
Page 6 |
Page 7 |
Page 8 |
Page 9 |
Page 10 |
Page 11 |
Page 12 |
Page 13 |
Page 14 |
Page 15 |
Page 16 |
Page 17 |
Page 18 |
Page 19 |
Page 20 |
Page 21 |
Page 22 |
Page 23 |
Page 24 |
Page 25 |
Page 26 |
Page 27 |
Page 28 |
Page 29 |
Page 30 |
Page 31 |
Page 32 |
Page 33 |
Page 34 |
Page 35 |
Page 36 |
Page 37 |
Page 38 |
Page 39 |
Page 40 |
Page 41 |
Page 42 |
Page 43 |
Page 44 |
Page 45 |
Page 46 |
Page 47 |
Page 48 |
Page 49 |
Page 50 |
Page 51 |
Page 52 |
Page 53 |
Page 54 |
Page 55 |
Page 56
