16 New Mass Spectrometer Platform Offers Greater Quantitative Sensitivity, Speed and Reproducibility
New Q Exactive HF-X Orbitrap mass spectrometer enables scientists to advance disease research and drug discovery Scientists studying complex protein samples can now take advantage of a new high-performing Orbitrap mass spectrometer designed to quickly and consistently produce superior data quality for challenging workflows across life science research and biopharma applications. The Thermo Scientific Q Exactive HF-X Hybrid Quadrupole Orbitrap mass spectrometer sets new standards for depth of analysis, quantitative accuracy and reproducibility, enabling scientists to advance disease research and drug discovery.
The Q Exactive HF-X mass spectrometer aims to provide sensitive, accurate and reproducible analyses of highly complex samples for various aspects of translational research and biopharma applications. This includes comprehensive proteome profiling and quantitation, biomarker discovery and verification, and full characterisation of complex biotherapeutics.
For R&D scientists, the Q Exactive HF-X instrument delivers extremely fast and accurate mass analysis, plus two-to-three-fold sensitivity improvements, delivering the same number of protein identifications in half of the time required for previous models. For biopharma scientists, the Q Exactive HF-X instrument provides up to eight times better signal to noise ratio for native, intact monoclonal antibody mass determination, glycoprofiling and purity checks.
“The study of biomolecules for potential use as disease markers, drug targets and therapeutic agents requires the analysis of highly complex samples,” said Ken Miller, Vice President, Omics Marketing, Chromatography and Mass Spectrometry, Thermo Fisher. “Scientists demand depth of analysis, data quality and analytical precision without sacrificing robustness or speed. The new Q Exactive HF-X platform includes technical advances meant to deliver significant performance improvements, making it the new flagship of the Q Exactive mass spectrometer product family.”
Dr Jesper Olsen, Associate Professor and Deputy Center Director of the Novo Nordisk Foundation and Center for Protein Research at the University of
Copenhagen, has been an early tester of the Q Exactive HF-X for protein research. “Our team has been applying proteomics technology to systems-wide analyses of dynamic post-translational modifications that regulate cell signal transduction pathways,” said Olsen. “Using the Q Exactive HF-X Hybrid, we have managed to identify 1,100 unique peptides per minute, which is a new world record.”
Thermo Fisher will showcase the new Q Exactive HF-X spectrometer as part of a workflow that includes advanced instrumentation, columns and software to support customers from sample to knowledge. The workflow includes: the Thermo Scientific UltiMate 3000 RSLCnano system, designed for nano, capillary and micro-flow applications requiring high-sensitivity and throughput; the Thermo Scientific EASY- Spray PepMap 15cm x 150µm Capillary column, designed for robust and reliable separations; Biognosys Spectronaut Pulsar software, now compatible with the Q Exactive HF-X instrument as well as previous Orbitrap instruments, intended to allow researchers to conduct data-independent analysis using MS1 quantitation for reproducible and accurate quantitation of thousands of proteins in a single run; and Thermo Scientific Proteome Discoverer 2.2 software meant for label-free quantitation, which offers reproducibility across experiments and extensive identification and quantification of proteins.
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New Tribrid Mass Spectrometer Delivers New Levels of Power and Performance for Protein and Small Molecule Characterisation
Scientists facing highly complex characterisation challenges can now gain a deeper understanding of their samples with new enhancements to the industry-leading Thermo Scientific Orbitrap Fusion Lumos Tribrid mass spectrometer that extend its power, performance and versatility.
“When we launched the Orbitrap Fusion Lumos Tribrid mass spectrometer, we redefined protein and small molecule quantitation and characterisation, and this year, we pushed these limits even further,” said Ken Miller, Vice President, Omics Marketing, Chromatography and Mass Spectrometry, Thermo Fisher. “The ability to intelligently select the most promising precursor ions, create new sequence- or structure-informative fragments, and characterise them to the level of fine isotope structure is a constellation of new capabilities that make the Fusion Lumos mass spectrometer essential for the most advanced proteomics, metabolomics and small molecule research discoveries.”
The Orbitrap Fusion Lumos instrument brings an unprecedented level of structural information for improved identification and characterisation to scientists performing top down proteomics, small molecule characterisation, lipidomics and biopharma research. New enhancements include:
Integrated Ultraviolet Photodissociation (UVPD) that allows researchers to perform large and small molecule structure determination on an LC time scale. Now an optional feature on Orbitrap Fusion Lumos systems, this unique fragmentation mode is designed to improve sequence coverage and antibody characterisation, decreases scrambling in top-down hydrogen deuterium exchange (HDX) experiments and created to be a complete solution for structural characterisation of lipids and other metabolites. This provides researchers with more complete structural information to solve their complex structure assignment challenges. The enhancement is supported by the new Thermo Scientific Xcalibur 4.1 software, an easy-to-use, flexible and efficient solution that is intended to enable simple method setup, data acquisition, processing and reporting through an intuitive interface.
New Advanced Peak Determination (APD) algorithm that is designed to improve performance of most proteomic workflows with high peptide and protein identification rates in data-dependent experiments.
1M resolution, which is now available for researchers who need ultra-high resolution to confidently measure fine isotope structures or separate isobaric compounds. This new option, used to obtain unique structural and quantitative information for a wide range of compound classes, aids scientists in proteomics, pharmaceutical, metabolomics, fluxomics and industrial chemical applications.
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New Technology and Software Developments Designed to Support Trace Elemental Analysis Announced
Thermo Fisher Scientific Inc has announced new technology and software developments in the field of plasma chemistry designed to support trace elemental analysis.
Thermo Fisher’s trace elemental analysis portfolio, includes the new Thermo Scientific iCAP TQ ICP-MS, designed to support ultra-low detection limits with ease of use. The newest addition to the ICP-MS portfolio harnesses triple quadrupole technology to extend ICP-MS performance and delivers advanced interference removal capabilities to overcome interferences in challenging matrices. With the flexibility of both single and triple quadrupole modes, the system offers a multi- elemental solution while maintaining reliable and reproducible data for a range of applications, including human and environmental health, and industrial and material science.
“We’re noticing laboratories have a growing need for lower detection limit capabilities with the highest accuracy to meet new requirements in trace elemental analysis,” said Shona McSheehy Ducos, ICP-MS Product Manager, Thermo Fisher. ”We develop our solutions with this in mind. Our new triple quad technology is designed both routine and research labs for the most challenging analytical applications.”
“At Thermo Fisher, in addition to supporting our customers, we strive to continuously extend our support to the research community,” said Lothar Rottmann, R&D Director, ICP-MS, Thermo Fisher.
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LAB ASIA - JANUARY/FEBRUARY 2018
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