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New Columns Accelerate LC/MS Analysis of Synthetic Oligonucleotides Oligo-MS™ columns for rapid and efficient LC/MS characterisation and quality control of synthetic RNA and DNA. Based
Phenomenex Inc introduced Clarity®
on the company’s core-shell particle technology, the new C18 columns deliver significantly shorter run times than traditional media, along with increased resolution and sensitivity. With the high resolving power of Clarity Oligo-MS, impurities in complex synthetic mixtures can be separated from the peak of interest in less than 10 minutes.
These new Oligo-MS columns, which are part of the Clarity BioSolutions portfolio, are packed with either 2.6µm or 1.7µm particles, enabling high efficiency on any HPLC or UHPLC platform. The Clarity Oligo-MS 2.6µm columns operate at reduced backpressures compared to other oligonucleotide-specific columns, delivering UHPLC performance on any LC instrument, and methods are easily transferable. The Clarity Oligo- MS 1.7µm columns boost the performance of existing sub-2µm methods on high-pressure systems.
With traditional, fully porous particles, efficiency decreases as flow rate increases, resulting in loss of resolution and sensitivity and longer overall analysis time. The Phenomenex core-shell technology enables high resolution and sensitivity over an extended linear velocity without generating excessive backpressure. These columns provide roughly twice the efficiency of fully porous 3-micron columns and three times the efficiency of fully porous 5-micron columns, with significantly lower limits of detection and quantitation.
Circle no. 317 SyringeAd LabAsia
Jan@FA.ai 12/2 Uninterrupted Productivity Across Routine GC-MS Applications
ANALYTICA NEWS
Thermo Fisher Scientific, Inc announced the new Thermo Scientific ISQ single quadrupole gas chromatography-mass spectrometry (GC-MS) system with a unique, non-venting full-source removal capability at Analytica 2010. Featuring the new ExtractaBrite™ ion source, the ISQ™ system offers simplified operation and maximum uptime for uninterrupted productivity across routine GC-MS applications including forensics, toxicology, food safety and environmental.
The ISQ GC-MS is a highly robust and rugged system that provides high-throughput sample analyses and 24/7 operation. The new ExtractaBrite removable ion source is designed to provide maximum uptime and productivity by extending the length of time between required source maintenance. When the
system requires maintenance, the time-consuming and labour-intensive procedures including breaking the vacuum, cooling off, cleaning, reassembling and restoring associated with conventional systems are eliminated. The entire ion source can be removed without venting the analyser. The new ISQ single quadrupole GC-MS also offers an extended mass range, from 1.2 to 1100 u, for analyses across a varied range of compounds.
Advanced electronics allow the ISQ to acquire and write data to disc at accelerated rates for truly high-speed acquisition in real-world applications. The sequential full scan/selected ion monitoring (SIM) capability provides qualitative and quantitative analyses in a single injection, for confirmation and screening in the same analytical run.
With the ISQ GC-MS, labs are able to operate continuously and productivity can be considerably improved. The innovative ISQ GC-MS represents the most advanced technology available today while providing the opportunity for future upgrades and options. The ISQ mass spectrometer is offered with either the Thermo Scientific FOCUS GC for routine GC-MS or with the full-featured TRACE GC Ultra for improved flexibility and performance.
Circle no. 318
PITTCON NEWS
Throughput Optimisation in Chromatography
Axel Semrau have launched Chronos version 3.0 as the ideal master software for the efficient automation of complex sample preparation procedures using CTC PAL samplers. Interfaces to other systems such as Xcalibur or ChemStation guarantee easy integration in existing systems. Chronos exchanges data with other systems and controls the entire processes. Based on intelligent time management Chronos significantly increases the throughput of analytical systems. Chronos optimises complex autosampler process sequences and reduces waiting times for all system components, GC(MS) or LC(MS) systems and autosamplers. This is enabled by the intelligent algorithm used by Chronos to organise parallel execution of several samples without any loss of precision or reproducibility. This replaces the usual serial processing of samples and represents an innovation, which increases significantly the efficiency of the laboratories.
ANALYTICA NEWS
Chronos enables very flexible and simple creation of the sample list. Through integration of Xcalibur and ChemStation Chronos links the sample list for the autosampler control with the data system list, so that the user only has to manage one sample list. This simplifies handling, saves time and avoids errors which could be caused by confusing different items.
A graphic representation of the sample processing is created at the touch of a button, which means that overall duration and current progress can be followed in real time. Multi-stage sample preparation procedures can be parallelised automatically by means of an integrated algorithm. A graphic representation illustrates the process sequence. Predefined tasks allow quick and flexible creation of methods.
Circle no. 319
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LAB ASIA - MARCH/APRIL 2010 - CHROMATOGRAPHY & SPECTROSCOPY
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