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Lanthanide Labelling Reagents Added to Product Range
Cambridge Research Biochemicals (CRB) has signed an exclusive deal with Bio-Nobile (BN) Products and Services to promote and sell QuickAllAssay™ labelling reagents in the UK. The ready-to-use reagents are used for labelling of proteins, antibodies and small molecules with a Europium chelate and are unique in that only one kit is required for labelling all assay formats including TR FRET (Time-Resolved Fluorescence Resonance Energy Transfer) and QRET (Quenched Resonance Energy Transfer assays) and for separation based enhanced time-resolved fluorescence assays.
The QuickAllAssay™ kit offers researchers looking to quantify biochemical markers a number of significant advantages over traditional assay technology. Separation based TRF assays, also known as Dissociation-Enhanced Lanthanide Fluorescent Immunoassays (DELFIA) are popular for research, as they offer a superior alternative to traditional ELISA technology as they are significantly more sensitive, have a broader dynamic range and are more robust than enzyme-based assays.
The QuickAllAssay™ kit can offer dual and triple label separation based assays which are now routinely being used by screening laboratories. Lanthanides are now the perfect choice of label with which to build such assays as they offer the unique possibility of building multi-label measurements within the same well.
CRB is a leading manufacturer and supplier of specialist custom peptides and antibodies and works with some of the largest pharmaceutical companies and research organisations in the world. The company is renowned for its high-level of customer support, help and advice and is able to identify in advance products that they would like to have made available to them such as the QuickAllAssay™ kit.
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ADVERTORIAL
Biosolve ULC/MS Grade Solvents High purity solvents and modifiers,
specifically suitable for use in demanding HPLC, ULC and MS applications.
Novel Liquid Chromatography systems, coupled to extremely sensitive Mass Spectrometric, optical and other advanced detectors allow ultra-high performance in qualitative and quantitative studies. This performance is challenged by the quality of the chemicals.
Biosolve ULC/MS grade features high chemical purity, excellent UV transmission, lowest peak impurity and drift under gradient conditions, low fluorescence impurities and low level of ionic background.
Demonstrates superior performance in MS and MS/MS applications by reducing the chemical background and by avoiding the formation of unwanted adducts, therefore will allow the acquisition of cleaner MS Spectra and Chromatograms, both in positive and negative ionisation modes.
Biosolve ULC/MS solvents and formulations are available in 1litre and 2.5 litre specially cleaned glass bottles and micro filtered at 0.1µm. and are packed under inert gas, for improved shelf life. Certificate of Analysis is per batch available.
Biosolve ULC/MS grade solvents, formulations and modifiers: the preferred choice for Chromatographers and Mass Spectrometrists.
MORE INFO. 102 Biosolve: a New Plant in France
For over three decades, we have produced and distributed selected high purity solvents, reagents and formulations for the research, pharmaceutical and biotechnology industries, and are now a major supplier in this field.
Biosolve and more recently Biosolve Chimie, our new plant established in Lorraine France, meet the latest quality and environmental ISO standards, manufacturing under stringent quality control processes and serving you with the highest quality products on the market.
Keeping Sport Clean with High Quality Reference Standards
The Anti-Doping Control Laboratory at Barcelona’s Hospital del Mar Medical Research Institute (IMIM) is a world-recognised facility performing dope testing of athletes and animals for national and international sporting events, and was an early adopter of LGC Standards LoGiCal range of reference materials. Immaculada Figuera, a chemist in the laboratory, explained: “We test around 4,000 human and animal samples a year from sporting events around the world, screening urine, blood and serum samples for controlled substances. We perform a wide range of gas and liquid chromatography-based protocols, and use LoGiCal reference standards for both qualitative and quantitative analyses.”
“The quality of our reference standards is vital to the analytical sensitivity of our techniques and, as an ISO 17025 accredited laboratory, it is essential that these standards are provided with a detailed Certificate of Analysis. LoGiCal standards combine high quality with excellent value for money, and we look closely at the LGC Standards’ product range when we need to purchase reference materials. We have always found LGC Standards easy to work with, and the company offers fast delivery.”
The LoGiCal product range focuses on the clinical and forensic sectors, and provides laboratories with access to over 1,000 of the most widely used standard reference materials.
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As our customer, you deserve excellent service, starting from the right packaging for your application through to swift and reliable delivery. We welcome you to contact us whenever you need our sound advice for quality, safety or product design, or to discuss the grade that best accommodates your special needs.
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Headspace Grade Solvents for the Analysis of ‘Organic Volatile Impurities’ (OVI’s)
OVI’s in pharmaceuticals, commonly referred as residual solvents, are trace organic volatile chemicals used or produced in the manufacturing of active substances, excipients, or in the preparation of medicinal products.
The solvent of choice is usually a critical parameter in the synthetic process, but since most of these solvents are not completely removed by practical manufacturing techniques, their content should be evaluated and justified.
In general identification and quantification of OVI's is conducted via Headspace- GC/FID. Guidelines for this procedure are set by the International Conference on Harmonization (ICH) method Q3C1, US Pharmacopoeia (USP) method 467, and the European Pharmacopoeia (EP) method 2.4.24 3.
Biosolve Headspace grade solvents are purified for the detection of OVI’s with the Headspace-GC technique. Products as DMA, DMF, DMI & DMSO are suitable as dissolution solvents for the analysis of OVI’s and show no major interference peaks in the elution range of common residual solvents.
Biosolve Headspace solvents: the preferred choice for the Analysis of ‘Organic Volatile Impurities’.
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