Carmichael’s Concise Review Coming Events
Due to COVID-19, please check to see if the listed events have been postponed or cancelled.
2020
APT&M 2020 – Atom Probe Tomography & Microscopy July 7–10, 2020 Oxford, England
https://aptm2020.web.ox.ac.uk
Microscopy & Microanalysis 2020
August 2–6, 2020 Milwaukee, WI
www.microscopy.org
16th International Congress of Histochemistry and Cytochemistry (ICHC)
August 30–September 2, 2020 Prague, Czech Republic
http://ichc2020.com
Neuroscience 2020 October 24–28, 2020
Washington, DC
www.sfn.org/meetings/neuroscience-2020
2020 MRS Fall Meeting & Exhibit
November 29–December 4, 2020 Boston, MA
www.mrs.org/fall2020
ASCB 2020 Annual Meeting
December 5–9, 2020 Philadelphia, PA
www.ascb.org/meetings-events/future-ascb-meetings
2021
Microscopy & Microanalysis 2021 August 1–5, 2021
Pittsburgh, PA
www.microscopy.org
2022
Microscopy & Microanalysis 2022 July 31–August 4, 2022
Portland, OR
www.microscopy.org
2023
Microscopy & Microanalysis 2023 July 24–28, 2023
Minneapolis, MN
www.microscopy.org
2024
Microscopy & Microanalysis 2024 July 28–August 1, 2024
Cleveland, OH
www.microscopy.org
8
Figure 1: Label-free SLAM microscopy image of a mammary tumor. The multimodal color channels include: Green – Second Harmonic Generation from collagen; Magenta – Third Harmonic Generation from interfaces, such as between lipid/aqueous compartments; Yellow – Two-Photon Excited Autofluorescence from FAD; Blue – Three-Photon Excited Autofluorescence from NAD(P)H. Extracellular vesicles appear primarily as blue/magenta single-pixel objects due to their NAD(P)H content and size.
doi:10.1017/S1551929520001054 2020 July
Visualizing Vesicles as Biomarkers in Cancer
Stephen W. Carmichael Mayo Clinic, Rochester, MN 55905
carmichael.stephen@
mayo.edu
Advances in optical imaging technologies have a way of revealing structures in
new ways, seeing things in a new light, and providing new information about funda- mental biological processes such as carcinogenesis. Two of the factors driving these technologies are new laser sources and new ways of pulse-shaping or manipulating light to enhance nonlinear optical imaging processes in tissues. Recent work has focused on using lower repetition-rate ultrafast lasers to pump photonic crystal fibers to generate stable, low-noise, widely coherent supercontinuum that can then be used to excite multiple nonlinear processes in tissues. Simultaneous label-free autofluorescence multi-harmonic (SLAM) microscopy was recently demonstrated to generate two- and three-photon autofluorescence and second- and third-harmonic generation imaging channels simultaneously, enabling structural, molecular, and metabolic imaging in
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