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• Reduced levels of oxidative stress


• Reduced monocytie chemotactic pro- tein-1, a chemical messenger (chemo- kine) associated with inflammatory processes within the arteries. • Reduced lipid accumulation in the heart muscle


• Reduced macrophage infiltration in the heart muscle


• Reduced levels of monocyte chemo- tactic protein-1 and fibrosis in the myo- cardium


• Reduced cardiac enlargement • Reduced ECG abnormalities


How can something as benign and commonplace as a fruit extract reverse so many aspects of coronary artery disease, simultaneously, as evidenced by the study above? The answer may lie in the fact that our ancestors co-evolved with certain foods (fruits in particular) for so long that a lack of adequate quantities of these foods may directly result in deteriorating organ function. Indeed, two-time Nobel Prize winner Linus Pauling argued that vitamin C deficiency is a fundamental cause of cardiovascular disease, owing to the fact that our hominid primate ancestors once had year-round access to fruits, and as a result lost the ability to synthesize it.


Pomegranate Found To Prevent Coronary Artery Disease Progression There's another obvious clue as to


how pomegranate may work its artery opening magic. Anyone who has ever tasted pomegranate, or consumed the juice, knows it has a remarkable astrin- gency, giving your mouth and gums that dry, puckering mouth feel. This cleansing sensation is technically caused, as with all astringents, by shrinking and disinfecting your mucous membranes. Anyone who drinks pomegranate


juice, or is lucky enough to eat one fresh, can understand why it is so effective at cleansing the circulatory system. Nature certainly planted enough poetic visual clues there for us: its juice looks like blood, and it does resemble a multi-chambered heart, at least when you consider its ap- pearance in comparison to most other fruits.


Indeed, your mouth and your arteries


are lined with the same cell type: epithe- lial cells. Together, they make up the epi- thelium, one of four basic tissue types within animals, along with connective tissue, muscle tissue and nervous tissue, and which comprises the interior walls of the entire circulatory system. So, when you feel that amazing cleansing effect in your mouth, this is in fact akin to what your circulatory system -- and the epithelium/ endothelium lining the inside of your veins and arteries -- "feels" as well.


The Pomegranate "Artery Cleaning" Clinical Trial Published in Clinical Nutrition in


2004 and titled, "Pomegranate juice con- sumption for 3 years by patients with ca- rotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation," Israeli re- searchers discovered pomegranate, admin- istered in juice form over the course of a year, reversed plaque accumulation in the carotid arteries of patients with severe, though symptomless, carotid artery steno- sis (defined as 70--90% blockage in the internal carotid arteries). The study consisted of nineteen pa-


tients, 5 women and 14 men, aged 65-75, non-smokers. They were randomized to receive either pomegranate juice or pla- cebo. Ten patients were in the pomegran- ate juice treatment group and 9 patients that did not consume pomegranate juice were in the control group. Both groups were matched with similar blood lipid and glucose concentrations, blood pressure, and with similar medication regimens which consisted of blood-pressure lower- ing (e.g. ACE inhibitors, calcium channel blockers) and lipid lowering drugs (e.g. statins). The ten patients in the treatment group


group received 8.11 ounces (240 ml) of pomegranate juice per day, for a period of 1 year, and five out of them agreed to continue for up to 3 years. The remarkable results were reported


as follows:


"The mean intima media thickness the left and right common carotid arteries in severe carotid artery steno- sis patients that consumed pomegran- ate juice for up to 1 year was reduced after 3, 6, 9 and 12 months of pome- granate juice consumption by 13%,


22%, 26% and 35%, respectively, in comparison to baseline values."


You can only imagine what would happen if a pharmaceutical drug was shown to reverse plaque build up in the carotid arteries by 13% in just 3 months! This drug would be lauded the life-saving miracle drug, and not only would be pro- moted and sold successfully as a multi- billion dollar blockbuster, but discussion would inevitably follow as to why it should be mandated.


While these results are impressive, if


not altogether groundbreaking for the field of cardiology, they may be even better than revealed in the stated therapeutic out- comes above. When one factors in that the carotid artery stenosis increased 9% within 1 year in the control group, the pomegranate intervention group may have seen even better results than indicated by the measured regression in intima media thickness alone. That is, if we assume that the pomegranate group had received no treatment, the thickening of their carotid arteries would have continued to progress like the control group at a rate of 9% a


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