ceuticals go, curcumin has been shown to be very effective against most types of cancer. It is well tolerated and very safe. Typically oral dosages are between 500 - 3000 mg. In animals it has been shown to slow down the aging process by quelling inflammation. It also seems to protect against radiation damage due to its strong anti-oxidant properties. It protects the DNA from environmental chemical damage, too. It also may help clean up some of the cellular trash that accumulates in diseases like Alzheimer’s disease. And, it seems to protect the skin and body from sun damage. Yes, it not only can help you feel younger, but help you look younger. And, this powerful plant chemical works synergistically with most other anti-aging plant chemicals like the next one, resveratrol.
3) Resveratrol - This is a plant chemical found in red wines, grapes, berries, peanut skins, and cocoa. The main source of resveratrol in supplements comes from the herb Polygonum or Japanese Knotweed. Resveratrol activates SIRT1 which has been shown to promote longevity in animal studies. In Traditional Chinese Medicine, Polygonum, aka He Shou Wu, is known as a great promoter of longevity. Typical dosages of resveratrol in supple- ments are between 50 and 200 mg/day. It is considered very safe to supplement with and appears to work synergistically with other anti-aging plant nutrients like curcumin, NAD+, green tea extract, quercitin and melatonin. Resveratrol mimicks some of the effects of the life-extending effects of caloric restriction. It protects the cardiovascular system numerous ways by optimizing endothelial function, lowering blood lipids, and preventing clot formation. It also seems to protect neurons through its anti-in- flammatory action, and by cleaning out the cellular trash as we age.
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4) Vitamin D - Vitamin D has been shown to prevent cancer, the flu, and boost overall immunity. It is stereotypically known to help strengthen bones, but does so much more for the body. Optimal levels are between 50-80 ng/ml. Most people are deficient in this vitamin and should supplement with it. Make sure to get it checked at least annually. Of all the supplements listed here, vitamin D has the most research on it for promoting health. Typical dosages of vitamin D in my clinic are at least 2000 IU/day. The research on vitamin D and longevity is intriguing to say the least. It has been shown to help prevent cognitive decline. People with ad- equate levels of vitamin D are not as prone to dementia as people with lower levels. People with optimal levels of vitamin D are also less likely to be prone to colds, flus, and pneumonia. Pneu- monia is huge killer of the elderly. Vitamin D improves protein homeostasis which positively affects multiple biochemical pro- cesses in the body, and thus has the potential of slowing down the aging process. Higher vitamin D levels are also associated with longer telomere length.
5) CoQ10 - CoQ10 supports mitochondrial function. Mitochon- dria are the power plants of the cells that provide your body with energy. When levels of CoQ10 fall mitochondrial function be- comes compromised and aging accelerates. In my clinical expe- rience using ubiquinol (the reduced form of CoQ10) seems to work better than using the ubiquinone (the oxidized form). Ubi- quinone has to first be converted to Ubiquinol in order for it to exert its antioxidant effects. We tend to use anywhere from 100 mg - 300 mg/day. Research in mice showed that supplementing with CoQ10 increased mean and maximum life span by 11.7 and 24%, respectively. That increase translates to an increase of at least 9 years in humans. Extended life span is also seen with other animals when supplemented with CoQ10. Studies also show that supplementing with CoQ10 not only
increases the quantity of life but also the quality of life. In animals and humans, supplementation improves various markers of aging. CoQ10 has a positive impact on various inflammatory processes, and it supports mitochondrial function in various diseases like cardiovascular disease and diabetes. It also supports stem cell function through its anti-oxidant action, and acts to stave off stem cell senescence.
Conclusions The supplements listed above are very safe to take and may
have very powerful anti-aging effects according to the evidence. Yes, it is true that at this point we do not have definitive proof that any of these actually give you extra quality years to your life, however, that evidence is intriguing to say the least. And, human studies are close at hand to answer this question. At any rate, taking them on a regular basis will do no harm and will help at the very least to lower your risk of many chronic diseases.
Next month, part 2 will cover herbs that promote logevity.
Written by Keoni Teta, ND, a medically trained naturopathic physician whose clinic is the Naturopathic Health Clinic of NC, located on Reynolda Road in Winston-Salem. Call 336-724-4452 for an appointment. Keoni is also the co-founder of Metabolic effect., and the co-author of 2 books. To subscribe to his newslet- ter, visit
www.FixYourBones.com. See ad on page 11.
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