C
its roles, consequences and management
Gut on Fire Inflammation:
I
t may seem silly to write a piece about celiac disease AND inflammation, as one cannot have celiac without inflamma- tion, and many of the pathological changes in the body and
their consequences are a direct result of inflammation; yet, it remains important to tease out these individual pieces to broad- en our understanding of not just celiac disease, but the health of the gastrointestinal system, and quite importantly: the relationship of these concepts to food.
What is Inflammation? Depending on what source you are looking at, or in what
context you are viewing the situation, inflammation is both the necessary response by the body for defense and healing and a major contributing factor to many disease states. Inflammation is a normal, predictable response by the im- mune system to pathogens and injury. White blood cells work in a highly sequential way to create, control and (hopefully) stop inflammation. A major way the white blood cells orchestrate this is through chemical messengers called cytokines. Cytokines are little bits of information that the white blood cells use to signal one another to rally, to call for reinforcements, or to back off. Predictable, tell-tale signs that inflammation is underway? Heat, redness, swelling and pain. This is a normal response. Think about a sprained ankle or a cut that is healing. The sequence in
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which the injury heals is quite predicatble, isn’t it? The truth is, without inflammation, we would die fairly
quickly in its absence. A balanced immune system is critical for optimum immune response.
A Normal Immune Response OK, then, so what is a balanced, healthy immune system?
The primary roles of a normal, optimal immune system are: 1. Identify infectious or injurious pathogens/substances (known as antigens) 2. Distinguish self (ie: non-threatening) from non-self (ie: threatening) 3. Assess the level of threat associated with infectious, toxic, or non-self antigens
4. Mount an appropriate response equivalent to the level of the threat 5. Repair any damage that occurs as a result of the immune response
Our immune system is the most highly evolved biological
system in our body. We tend to be very proud of our big brains, frontal cortexes and powers of deduction, but our immune system is far more evolved and complex than out brains and central nervous system. Our immune system is also completely ruthless
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