BIOTECHNOLOGY 59
For example, the FerMac 310/60 is designed with modern multi-function laboratories in mind and born out of the most rigorous testing. Tis stirred tank bioreactor offers the control and footprint of a perfectly integrated system combined with the flexibility of a modular system, including: powerful, intuitive measurement and control system; a wide range of fully autoclavable vessels with a novel, easily replaceable drive shaft system; four pumps fitted as standard (additional two pump module available); and the fermenter system can efficiently tackle batch, fed-batch and continuous flow fermentations.
Electrolab’s FerMac 320 is its new mid-priced bioreactor system. By combining a specially designed range of vessels with a variation on its established 360 controller, the company says FerMac 320 gives users outstanding value-for-money with the reassurance of proven
reliability. Features include: a vessel-mounted motor with easy coupling system; intuitive measurement and control system; and it can be used as a batch bioreactor in fed-batch or continuous culture mode.
Low maintenance costs Te FerMac 200 bioreactor is a modular system which is marketed as having the perfect combination of performance and ease-of-use. For example, all modules are totally independent and stackable for a neat, combined unit; low purchase and maintenance costs maximise benefits from a limited budget; and modules are available individually for specific control requirements.
Alongside other bioreactor technologies, GE Healthcare Life Sciences offers the Xcellerex XDR stirred-tank bioreactor systems that are designed to minimise scale-up risks and facilitate the goal of achieving a
robustness, purity, and potency of the final manufacturing-scale process that is comparable to the process in development scale.
Technology transfer using XDR bioreactor systems is straightforward, minimising the need for costly and time- consuming process redesign.
Te design of XDR systems is based on the same principles as conventional stainless steel bioreactors. A traditional scaling methodology, based on measures such as shear, tip speed, power, and fluid velocity, is used. Consistent vessel geometries and efficient mass transfer combine for an easily scalable, single-use system.
Te XDR-50 single use vessel offers standard accessories that can be adapted to various process requirements. For example there are gas mass flow and liquid pump options for highly productive cultures.
Complete, turn-key bioreactors and fermenters with dedicated X-Station controllers are also available.
Te company says that as the XDR-50 single-use bioreactors are a modular platform with scalable working volumes up to 2000l, they offer smooth transfer from process development to manufacturing scale, with the convenience and cost-effectiveness of single-use technology.
For its part the XDR-10 single- use bioreactor system is sized for the bench top, yet allows smooth scale-up to full production. It includes a low shear, high input-power impeller for gentle, efficient mixing for sensitive cells or media. Sparging flexibility offers excellent adaptability to a broad range of cell lines. Handling volumes from 4.5l to 10l, this model is suitable for GMP clinical and commercial manufacture of biotherapeutics, vaccines, and other biologics.
For more information ✔ at
www.scientistlive.com/eurolab
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