BIOTECHNOLOGY 57
Bioreactors aim for versatility and reliability
The latest generation of bioreactors have smaller footprints, are more versatile, reliable and user friendly, and minimise scale up risks.
La toute dernière génération de bioréacteurs a des empreintes plus petites, est plus versatile, plus fiable et plus facile à utiliser et elle minimise les risques d’accroissement d’échelle.
Die Bioreaktoren der neuesten Generation sind kleiner, vielseitiger, zuverlässiger und benutzerfreundlicher und minimieren außerdem das Scale-Up-Risiko.
A
pplikon Biotechnology has launched micro- Matrix, describing
it as the next generation in microbioreactors.
Micro-Matrix offers total control over 24 independent bioreactors in a simple microtitre plate footprint. Each of the 24 bioreactors on a plate offer independent controls similar to their larger stirred-tank relatives, including pH, temperature, dissolved oxygen control, individual liquid additions and up to four separate, individually controlled gas additions.
Advanced control strategies are also available to users interested in cascade controls (up to five actuators per process variable), time-based setpoint changes, and event-triggered liquid feeds. Liquid feeding is available using varying types of addition profiles, too.
Fig. 1. The BioBLU 0.3f is the first fully- instrumented single-use bioreactor designed specifically for microbial applications.
A major feature of the instrument is the software for processing, data storage, data presentation and data analysis. Te micro- Matrix software offers an easy way to operate 24 bioreactors in parallel, plus simple comparisons of large numbers of experimental cultures. Using an instinctive left- to-right progression, the interface guides operators through
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experimental setup, instrument configuration, control strategy definition, and data visualisation. It is also possible to define time- and event-based control actions, and all data can be exported from the instrument post or during the experiment.
Te polystyrene bioreactor cassettes conform to the SBS
standard for 24 well culture plates (128 x 86mm). Te total volume per bioreactor is 10 ml with working volumes from 1 to 7ml (recommended working volume is 5ml). Te square bioreactors are designed based upon the company’s popular 24-well microtitre plate design to optimise mixing and gas transfer, and Applikon has characterised
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